Sun, Wei’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2022 | 10541-78-3

Chemical Communications (Cambridge, United Kingdom) published new progress about Aromatic amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Product Details of C8H11NO.

Sun, Wei; Raimbach, William A. T.; Elliott, Luke D.; Booker-Milburn, Kevin I.; Harrowven, David C. published the artcile< New approaches to ondansetron and alosetron inspire a versatile, flow photochemical method for indole synthesis>, Product Details of C8H11NO, the main research area is aryl amino cycloalkenone iodine catalyst oxidative photocyclization; tetrahydro cycloalkaindolone preparation; arylamino alkenone iodine catalyst oxidative photocyclization; indolyl alkenone preparation.

An oxidative photocyclization of N-arylenaminones to indoles was described, that mirrored the Fischer indole synthesis but used anilines in place of arylhydrazines. Its value was exemplified with new approaches to the WHO-listed APIs ondansetron and alosetron.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aromatic amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Product Details of C8H11NO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yamaoka, Yousuke’s team published research in Synthesis in 2022-05-31 | 190788-60-4

Synthesis published new progress about Oxidative coupling reaction (oxidative biaryl coupling). 190788-60-4 belongs to class ethers-buliding-blocks, and the molecular formula is C13H19BO3, SDS of cas: 190788-60-4.

Yamaoka, Yousuke; Yamakawa, Takuro; Tateishi, Kaito; Takasu, Kiyosei published the artcile< Total Synthesis of Cryptopleurine and Its Analogues>, SDS of cas: 190788-60-4, the main research area is total synthesis cryptopleurine analog.

Total synthesis of phenanthroquinolizidine alkaloid (±)-cryptopleurine (I) was achieved in 8 steps from com. available 2-pyridinecarboxaldehyde and the epoxide derived from methyleugenol. The key intermediate vinyl triflate enables the divergent synthesis of cryptopleurine derivatives by late-stage installation of various substituents on the C-ring.

Synthesis published new progress about Oxidative coupling reaction (oxidative biaryl coupling). 190788-60-4 belongs to class ethers-buliding-blocks, and the molecular formula is C13H19BO3, SDS of cas: 190788-60-4.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Varni, Anthony J’s team published research in Journal of Organic Chemistry in 2020-05-15 | 190788-60-4

Journal of Organic Chemistry published new progress about Aryl iodides Role: RCT (Reactant), RACT (Reactant or Reagent). 190788-60-4 belongs to class ethers-buliding-blocks, and the molecular formula is C13H19BO3, Reference of 190788-60-4.

Varni, Anthony J.; Bautista, Michael V.; Noonan, Kevin J. T. published the artcile< Chemoselective Rhodium-Catalyzed Borylation of Bromoiodoarenes Under Mild Conditions>, Reference of 190788-60-4, the main research area is rhodium catalyst chemoselective borylation bromoiodoarene preparation bromoaryl boronate; aryl bromide boronate trifluoroborate preparation Suzuki coupling polymerization substrate.

A chemoselective rhodium-catalyzed borylation has been developed for the preparation of aryl boronate esters. The reaction proceeds under mild conditions with excellent selectivity for C-I bonds in bromoiodoarenes and exhibits broad functional group tolerance. This procedure can act as a complementary approach toward bifunctional arenes along with other metal-catalyzed borylations. Addnl., the reaction’s utility in the preparation of monomers for metal-catalyzed cross-coupling polymerization is demonstrated.

Journal of Organic Chemistry published new progress about Aryl iodides Role: RCT (Reactant), RACT (Reactant or Reagent). 190788-60-4 belongs to class ethers-buliding-blocks, and the molecular formula is C13H19BO3, Reference of 190788-60-4.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wucher, Philipp’s team published research in ACS Catalysis in 2014-08-01 | 17100-64-0

ACS Catalysis published new progress about Crystal structure. 17100-64-0 belongs to class ethers-buliding-blocks, and the molecular formula is C8H9BrO2, Computed Properties of 17100-64-0.

Wucher, Philipp; Schwaderer, Judith B.; Mecking, Stefan published the artcile< Solid-Supported Single-Component Pd(II) Catalysts for Polar Monomer Insertion Copolymerization>, Computed Properties of 17100-64-0, the main research area is solid supported palladium catalyst preparation polar monomer insertion copolymerization; polystyrene supported methylpalladium sulfonatophenylphosphine complex preparation crystal mol structure; clay silica physisorbed methylpalladium sulfonatophenylphosphine complex preparation ethylene polymerization; montmorillonite clay supported methylpalladium sulfonatophenylphosphine complex preparation catalyst.

Heterogenized representatives of neutral phosphine sulfonato Pd(II) complexes for polar monomer insertion polymerization were prepared by two different approaches. [{κ2-(P,O)-(2-anisyl)2PC6H4SO2O}Pd(Me)L] (L = pyr, dmso, or Cl) complexes were physisorbed on inorganic substrates, namely, clay or silica. In addition, new phosphine sulfonato complexes bearing hydroxyl linker groups at the nonchelating P-aryl moiety were prepared These complexes were covalently tethered to cross-linked polystyrene. All immobilized palladium complexes are active in ethylene polymerization and ethylene/MA copolymerization without any addnl. cocatalyst. In addition, separation from the polymer solution formed and reutilization for another polymerization were demonstrated for polystyrene-bound complexes.

ACS Catalysis published new progress about Crystal structure. 17100-64-0 belongs to class ethers-buliding-blocks, and the molecular formula is C8H9BrO2, Computed Properties of 17100-64-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Procopiou, Panayiotis A’s team published research in Journal of Medicinal Chemistry in 2011-04-14 | 52244-70-9

Journal of Medicinal Chemistry published new progress about Alkylation. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Related Products of 52244-70-9.

Procopiou, Panayiotis A.; Browning, Christopher; Buckley, Jennifer M.; Clark, Kenneth L.; Fechner, Lise; Gore, Paul M.; Hancock, Ashley P.; Hodgson, Simon T.; Holmes, Duncan S.; Kranz, Michael; Looker, Brian E.; Morriss, Karen M. L.; Parton, Daniel L.; Russell, Linda J.; Slack, Robert J.; Sollis, Steven L.; Vile, Sadie; Watts, Clarissa J. published the artcile< The Discovery of Phthalazinone-Based Human H1 and H3 Single-Ligand Antagonists Suitable for Intranasal Administration for the Treatment of Allergic Rhinitis>, Related Products of 52244-70-9, the main research area is phthalazinone derivative preparation intranasal antihistamine H1 H3 allergic rhinitis.

A series of potent phthalazinone-based human H1 and H3 bivalent histamine receptor antagonists, suitable for intranasal administration for the potential treatment of allergic rhinitis, were identified. Blockade of H3 receptors is thought to improve efficacy on nasal congestion, a symptom of allergic rhinitis that is currently not treated by current antihistamines. Two analogs (56a and 56b) had slightly lower H1 potency (pA2 9.1 and 8.9, resp., vs 9.7 for the clin. gold-standard azelastine), and H3 potency (pKi 9.6 and 9.5, resp., vs 6.8 for azelastine). Compound 56a had longer duration of action than azelastine, low brain penetration, and low oral bioavailability, which coupled with the predicted low clin. dose, should limit the potential of engaging CNS-related side-effects associated with H1 or H3 antagonism.

Journal of Medicinal Chemistry published new progress about Alkylation. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Related Products of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yong, Cassandra’s team published research in ChemMedChem in 2019 | 10305-42-7

ChemMedChem published new progress about Antimitotic agents. 10305-42-7 belongs to class ethers-buliding-blocks, and the molecular formula is C3H8ClNO2S, Electric Literature of 10305-42-7.

Yong, Cassandra; Devine, Shane M.; Gao, Xuexin; Yan, Angelina; Callaghan, Richard; Capuano, Ben; Scammells, Peter J. published the artcile< A Novel Class of N-Sulfonyl and N-Sulfamoyl Noscapine Derivatives that Promote Mitotic Arrest in Cancer Cells>, Electric Literature of 10305-42-7, the main research area is sulfonyl sulfamoyl noscapine derivative preparation cancer structure; anticancer agents; antimitotic agents; microtubule targeting agents; natural products; noscapine derivatives.

Noscapine displays weak anticancer efficacy and numerous research efforts have attempted to generate more potent noscapine analogs. These modifications included the replacement of the N-Me group in the 6′-position with a range of substituents, where N-ethylcarbamoyl substitution was observed to possess enhanced anticancer activity. Herein, we describe advances in this area, namely the synthesis and pharmacol. evaluation of a series of N-sulfonyl and N-sulfamoyl noscapine derivatives A number of these sulfonyl-containing noscapinoids demonstrated improved activities compared to noscapine. ((R)-5-((S)-4,5-Dimethoxy-1,3-dihydroisobenzofuran-1-yl)-4-methoxy-6-((1-methyl-1H-imidazol-4-yl)sulfonyl)-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline) (14 q) displayed sub-micromolar activities of 560, 980, 271 and 443 nM against MCF-7, PANC-1, MDA-MB-435 and SK-MEL-5 cells, resp. This antiproliferative effect was also maintained against drug-resistant NCI/AdrRES cells despite high expression of the multidrug efflux pump, P-glycoprotein.

ChemMedChem published new progress about Antimitotic agents. 10305-42-7 belongs to class ethers-buliding-blocks, and the molecular formula is C3H8ClNO2S, Electric Literature of 10305-42-7.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Katayama, Shin-taro’s team published research in Heterocyclic Communications in 2019 | 10541-78-3

Heterocyclic Communications published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Computed Properties of 10541-78-3.

Katayama, Shin-taro; Nishino, Hiroshi published the artcile< Facile synthesis of spiro[cyclohexane-1,3'-indoline]-2,2'-diones>, Computed Properties of 10541-78-3, the main research area is phenyl methyl oxocyclohexane carboxamide preparation one pot oxidative heterocyclization; methylspiro oxocyclohexane indolinone preparation.

Spiro[cyclohexane-1,3′-indoline]-2,2′-diones were easily prepared in good to high yields by the oxidation of N-aryl-N-methyl-2-oxocyclohexane-1-carboxamides in one-pot with a short reaction time. The spiroindolinediones could be important for the total synthesis of natural products.

Heterocyclic Communications published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Computed Properties of 10541-78-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Schmidt, Ulrike’s team published research in Molecules in 2018 | 56724-03-9

Molecules published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 56724-03-9 belongs to class ethers-buliding-blocks, and the molecular formula is C9H10O2, HPLC of Formula: 56724-03-9.

Schmidt, Ulrike; Theumer, Gabriele; Jaeger, Anne; Kataeva, Olga; Wan, Baojie; Franzblau, Scott G.; Knoelker, Hans-Joachim published the artcile< Synthesis and activity against Mycobacterium tuberculosis of olivacine and oxygenated derivatives>, HPLC of Formula: 56724-03-9, the main research area is olivacine oxygenated derivative preparation antitubercular; catalysis; cyclization; inhibitory activity; olivacine; palladium; pyrido[4,3-b]carbazoles.

The tetracyclic pyrido[4,3-b]carbazole olivacine I and its four oxygenated derivatives have been synthesized by a late-stage palladium-catalyzed Heck-type cyclization of the pyrrole ring as a key step. All the final compounds were evaluated for their antitubercular activity. In a test for the inhibition of the growth of Mycobacterium tuberculosis, 9-methoxyolivacine showed the most significant inhibitory activity against Mycobacterium tuberculosis, with an MIC90 value of 1.5 μM.

Molecules published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 56724-03-9 belongs to class ethers-buliding-blocks, and the molecular formula is C9H10O2, HPLC of Formula: 56724-03-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Liang, Yuwei’s team published research in Chinese Journal of Chemistry in 2022-06-15 | 10541-78-3

Chinese Journal of Chemistry published new progress about Alkylation. 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Safety of 2-Methoxy-N-methylaniline.

Liang, Yuwei; Niu, Linbin; Liang, Xing-An; Wang, Shengchun; Wang, Pengjie; Lei, Aiwen published the artcile< Electrooxidation-Induced C(sp3)-H/C(sp2)-H Radical-Radical Cross-Coupling between Xanthenes and Electron-Rich Arenes>, Safety of 2-Methoxy-N-methylaniline, the main research area is xanthene aryl preparation; arene electrooxidation radical cross coupling xanthene.

Herein, an electrooxidation-induced alkylation of electron-rich arenes, such as anilines, imidazo[1,2-a]pyridines, etc., with xanthenes with H2 evolution under exogenous oxidant-free conditions, avoiding the utilization of metal catalysts, is reported. This protocol is well performed with various electron-rich aniline derivatives and nitrogen-containing heterocyclic compounds This electro-oxidative C(sp3)-H arylation represents an important expansion for the classic arenes alkylation, thereby proving that an attractive strategy for the developments of radical cross-coupling chem. was anticipated.

Chinese Journal of Chemistry published new progress about Alkylation. 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Safety of 2-Methoxy-N-methylaniline.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Xiong, Ni’s team published research in Organic Letters in 2021-11-19 | 52244-70-9

Organic Letters published new progress about Aliphatic alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Safety of 4-(4-Methoxyphenyl)-1-butanol.

Xiong, Ni; Li, Yang; Zeng, Rong published the artcile< Iron-Catalyzed Photoinduced Remote C(sp3)-H Amination of Free Alcohols>, Safety of 4-(4-Methoxyphenyl)-1-butanol, the main research area is alkanol diazene iron catalyst regioselective photoredox amination; aminoalkanol preparation.

A general photocatalytic protocol for the remote C(sp3)-H bond amination of free alkanols was reported. The electron transfer between the abundant and inexpensive catalyst FeCl3 and simple alkanols under blue LED irradiation enabled the alkoxy radical formation under mild redox-neutral conditions, without addnl. oxidant and prefunctionalization. The subsequent selective 1,5-hydrogen atom transfer (HAT) and amination provided a simple and efficient way to access mol. complexity from readily available and bulk alcs.

Organic Letters published new progress about Aliphatic alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Safety of 4-(4-Methoxyphenyl)-1-butanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem