Yong, Cassandra; Devine, Shane M.; Gao, Xuexin; Yan, Angelina; Callaghan, Richard; Capuano, Ben; Scammells, Peter J. published the artcile< A Novel Class of N-Sulfonyl and N-Sulfamoyl Noscapine Derivatives that Promote Mitotic Arrest in Cancer Cells>, Electric Literature of 10305-42-7, the main research area is sulfonyl sulfamoyl noscapine derivative preparation cancer structure; anticancer agents; antimitotic agents; microtubule targeting agents; natural products; noscapine derivatives.
Noscapine displays weak anticancer efficacy and numerous research efforts have attempted to generate more potent noscapine analogs. These modifications included the replacement of the N-Me group in the 6′-position with a range of substituents, where N-ethylcarbamoyl substitution was observed to possess enhanced anticancer activity. Herein, we describe advances in this area, namely the synthesis and pharmacol. evaluation of a series of N-sulfonyl and N-sulfamoyl noscapine derivatives A number of these sulfonyl-containing noscapinoids demonstrated improved activities compared to noscapine. ((R)-5-((S)-4,5-Dimethoxy-1,3-dihydroisobenzofuran-1-yl)-4-methoxy-6-((1-methyl-1H-imidazol-4-yl)sulfonyl)-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline) (14 q) displayed sub-micromolar activities of 560, 980, 271 and 443 nM against MCF-7, PANC-1, MDA-MB-435 and SK-MEL-5 cells, resp. This antiproliferative effect was also maintained against drug-resistant NCI/AdrRES cells despite high expression of the multidrug efflux pump, P-glycoprotein.
ChemMedChem published new progress about Antimitotic agents. 10305-42-7 belongs to class ethers-buliding-blocks, and the molecular formula is C3H8ClNO2S, Electric Literature of 10305-42-7.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem