Month: November 2022

On October 15, 2009, Chu, Li-Qiang; Knoll, Wolfgang; Foerch, Renate published an article.Application In Synthesis of 2-(2-(Vinyloxy)ethoxy)ethanol The title of the article was Plasma polymerized non-fouling thin films for DNA immobilization. And the article contained the following:

Development of DNA sensors has been an issue of great interest, owing to their potential applications in different fields, such as the diagnosis of infectious diseases, food quality control, or for environmental monitoring. Most DNA sensors involved the immobilization of single-stranded oligonucleotides, so-called DNA probes, onto the sensor surfaces. Here we report on a new approach for DNA probe immobilization using the streptavidin-biotin assembly coupled with a non-fouling thin film. Pulsed plasma polymerization of di(ethylene glycol) monovinyl ether (ppEO2) will result in non-fouling thin films, which are employed to immobilize streptavidin. By careful control of the thickness and the chem. of ppEO2 films, the embedded streptavidin are able to bind the biotinylated oligonucleotides. The resulting DNA sensors show good resistance towards adsorption of both BSA and fibrinogen, and are employed to discriminate different DNA sequences from protein-containing sample solutions, as seen by surface plasmon enhanced fluorescence spectroscopy (SPFS). This result suggests that the present sensor is very promising for the detection of a DNA sequence from a complex solution The experimental process involved the reaction of 2-(2-(Vinyloxy)ethoxy)ethanol(cas: 929-37-3).Application In Synthesis of 2-(2-(Vinyloxy)ethoxy)ethanol

The Article related to sequence plasma polymerization diethylene glycol monovinyl ether dna probe, Biochemical Genetics: Methods and other aspects.Application In Synthesis of 2-(2-(Vinyloxy)ethoxy)ethanol

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On March 31, 2021, Zhou, Fei; Last, Robert L.; Pichersky, Eran published an article.Application of 91-16-7 The title of the article was Degradation of salicylic acid to catechol in Solanaceae by SA 1-hydroxylase. And the article contained the following:

The hormone salicylic acid (SA) plays crucial roles in plant defense, stress responses, and in the regulation of plant growth and development. Whereas the biosynthetic pathways and biol. functions of SA have been extensively studied, SA catabolism is less well understood. In this study, we report the identification and functional characterization of an FAD/NADH-dependent SA 1-hydroxylase from tomato (Solanum lycopersicum; SlSA1H), which catalyzes the oxidative decarboxylation of SA to catechol. Transcript levels of SlSA1H were highest in stems and its expression was correlated with the formation of the methylated catechol derivatives guaiacol and veratrole. Consistent with a role in SA catabolism, SlSA1H RNAi plants accumulated lower amounts of guaiacol and failed to produce any veratrole. Two O-methyltransferases involved in the conversion of catechol to guaiacol and guaiacol to veratrole were also functionally characterized. Subcellular localization analyses revealed the cytosolic localization of this degradation pathway. Phylogenetic anal. and functional characterization of SA1H homologs from other species indicated that this type of FAD/NADH-dependent SA 1-hydroxylases evolved recently within the Solanaceae family. The experimental process involved the reaction of 1,2-Dimethoxybenzene(cas: 91-16-7).Application of 91-16-7

The Article related to sa1h salicylic acid degradation catechol solanum, Plant Biochemistry: Metabolism and other aspects.Application of 91-16-7

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Andre, Mathieu; Tarrit, Sebastien; Couret, Marie-Joelle; Galmier, Marie-Josephe; Debiton, Eric; Chezal, Jean-Michel; Mounetou, Emmanuelle published an article in 2013, the title of the article was Spacer optimization of new conjugates for a melanoma-selective delivery approach.Application of 929-37-3 And the article contains the following content:

In the search for more selective anticancer drugs, we designed and synthesized seven conjugates varying the structure of the linker connecting the 5-iodo-2′-deoxyuridine (IUdR) to the ICF 01012 melanoma-carrier for potential intratumoral specific drug release. Chem. and in vitro metabolic stability evaluations showed that, except for the ester conjugate (1), the ketal (2b), acetal (2a), carbonate (4) and carbamate (3) conjugates were compatible with our approach. The acetal (2a) and its PEGylated derivative (2c) were of particular interest for further in vivo development owing to their resp. pH-dependent stability and limited metabolic degradation in order to exploit the acidic subcellular environment of malignant melanocytes to trigger the release of therapeutics upon internalization in cells. The experimental process involved the reaction of 2-(2-(Vinyloxy)ethoxy)ethanol(cas: 929-37-3).Application of 929-37-3

The Article related to antitumor melanoma icf01012 iododeoxyuridine conjugate spacer, Pharmaceuticals: Pharmaceutics and other aspects.Application of 929-37-3

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On September 30, 2008, Thevenot, Paul; Cho, Jai; Wavhal, Dattatray; Timmons, Richard B.; Tang, Liping published an article.Synthetic Route of 929-37-3 The title of the article was Surface chemistry influences cancer killing effect of TiO2 nanoparticles. And the article contained the following:

Photocatalyzed titanium dioxide (TiO2) nanoparticles were shown to eradicate cancer cells. However, the required in situ introduction of UV light limits the use of such a therapy in humans. In the present study the nonphotocatalytic anticancer effect of surface-functionalized TiO2 was examined Nanoparticles bearing -OH, -NH2, or -COOH surface groups were tested for their effect on in vitro survival of several cancer and control cell lines. The cells tested included B16F10 melanoma, Lewis lung carcinoma, JHU prostate cancer cells, and 3T3 fibroblasts. Cell viability was observed to depend on particle concentrations, cell types, and surface chem. Specifically, -NH2 and -OH groups showed significantly higher toxicity than -COOH. Microscopic and spectrophotometric studies revealed nanoparticle-mediated cell membrane disruption leading to cell death. The results suggest that functionalized TiO2, and presumably other nanoparticles, can be surface-engineered for targeted cancer therapy. The experimental process involved the reaction of 2-(2-(Vinyloxy)ethoxy)ethanol(cas: 929-37-3).Synthetic Route of 929-37-3

The Article related to titanium dioxide nanoparticle surface functional group antitumor, Pharmaceuticals: Pharmaceutics and other aspects.Synthetic Route of 929-37-3

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On August 15, 2006, Chu, Liqiang; Knoll, Wolfgang; Foerch, Renate published an article.Recommanded Product: 929-37-3 The title of the article was Biologically multifunctional surfaces using plasma polymerization methods. And the article contained the following:

The authors report on the development of a multilayer system, which allows for specific DNA binding reactions to occur at the surface, but at the same time shows antifouling properties, thus minimizing the nonspecific adsorption of proteins (BSA). The synthesis involves the combination of plasma polymerization and streptavidin-biotin assembly. DNA sensing is achieved using SPFS. Antifouling properties are tailored by controlling the film thickness, together with the effects of the swelling in buffer solution and by the sp. surface chem. design. Preliminary hybridization experiments show promising results. The experimental process involved the reaction of 2-(2-(Vinyloxy)ethoxy)ethanol(cas: 929-37-3).Recommanded Product: 929-37-3

The Article related to multilayer plasma polymerization dna hybridization protein serum albumin, Biochemical Methods: Apparatus and other aspects.Recommanded Product: 929-37-3

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On December 16, 2008, Roy, Dhruvajyoti; Kwak, Ju-Won; Maeng, Wan Joo; Kim, Hyungjun; Park, Joon Won published an article.Formula: C6H12O3 The title of the article was Dendron-Modified Polystyrene Microtiter Plate: Surface Characterization with Picoforce AFM and Influence of Spacing between Immobilized Amyloid Beta Proteins. And the article contained the following:

A polystyrene microtiter plate was coated with a mol. layer of a cone-shaped dendron as a means of providing proper spacing between immobilized biomols. For the coating preparation, di(ethylene glycol) vinyl ether was grafted onto the surface of the microtiter plate by a plasma process followed by self-assembly of a second-generation dendron (9-acid) or a third-generation dendron (27-acid). Contact angle anal. revealed a pronounced increase in the hydrophilicity upon plasma grafting, while the hydrophilicity reverted/decreased after dendron immobilization. For anal. by force-based at. force microscopy (AFM), oligonucleotides were immobilized onto the AFM tip and the plate. The DNA-DNA interaction was observed at all spots examined, which implied that coating of the dendrons was uniform over the entire surface. The effectiveness for biomol. assays of the spacing on dendron-modified microtiter plates was examined by carrying out an ELISA, where enhanced detection of different fragments of amyloid beta protein (Aβ) was observed when compared with other conventional plates, such as untreated polystyrene or maleic anhydride activated plates. The pos. influence of the mesospacing between biomols. on the microtiter plates for this assay was confirmed. The experimental process involved the reaction of 2-(2-(Vinyloxy)ethoxy)ethanol(cas: 929-37-3).Formula: C6H12O3

The Article related to dendron modified polystyrene microtiter plate immobilized amyloid beta protein, Biochemical Methods: Apparatus and other aspects.Formula: C6H12O3

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Ether – Wikipedia,
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Jiang, Xiaojia; Zang, Mingsong; Li, Fei; Hou, Chunxi; Luo, Quan; Xu, Jiayun; Liu, Junqiu published an article in 2021, the title of the article was Highly sensitive detection of paraquat with pillar[5]arenes as aptamer in alpa-hemolysin nanopore.Product Details of 150-78-7 And the article contains the following content:

Recently, biol. nanopore-based techniques have attracted more and more attention in the field of single-mol. detection because they allow real-time, sensitive, high-throughput anal. Herein, we report an engineered biol. nanopore sensor by introducing a macrocyclic host mol. carboxylatopillar[5]arene (CP[5]A) that acts as an aptamer into the lumen of a mutant (E111R/K147R)7 αHL nanopore for detecting highly toxic paraquat (PQ) via host-guest interactions at the single-mol. level. By taking advantage of introducing pos. charged arginine (Arg) into the lumen of the αHL nanopore, our engineered nanopore sensor exhibits higher stability. More importantly, this nanopore sensor shows high sensitivity, and the limit of detection (LOD) for PQ can reach a nanomolar level of 0.37 ppb. The CP[5]A-based nanopore sensing strategy developed in this work may bring inspiration for single-mol. detection and hold great potential in public health applications. The experimental process involved the reaction of 1,4-Dimethoxybenzene(cas: 150-78-7).Product Details of 150-78-7

The Article related to paraquat biosensor arginine hemolysin nanopore carboxylatopillararene, Biochemical Methods: Electrical and other aspects.Product Details of 150-78-7

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On May 4, 2006, Ghosh, Shomir; Elder, Amy; Guo, Jianping; Mani, Ukti; Patane, Michael; Carson, Kenneth; Ye, Qing; Bennett, Robert; Chi, Shannon; Jenkins, Tracy; Guan, Bing; Kolbeck, Roland; Smith, Sean; Zhang, Cheng; LaRosa, Gregory; Jaffee, Bruce; Yang, Hua; Eddy, Priya; Lu, Chuang; Uttamsingh, Vinita; Horlick, Robert; Harriman, Geraldine; Flynn, Daniel published an article.Reference of 3-(2-Methoxyphenoxy)benzaldehyde The title of the article was Design, Synthesis, and Progress toward Optimization of Potent Small Molecule Antagonists of CC Chemokine Receptor 8 (CCR8). And the article contained the following:

Activation of CCR8 by its ligand CCL1 may play an important role in diseases such as asthma, multiple sclerosis, and cancer. The study of small mol. CCR8 antagonists will help establish the validation of these hypotheses. We report the design, synthesis, and progress toward optimization of potent small mol. CCR8 antagonists identified from a high-throughput screen. These analogs exhibit good potency in binding and chemotaxis assays, show good selectivity vs. the hERG channel, and have good eADME (early absorption, distribution, metabolism, and excretion) profiles. The experimental process involved the reaction of 3-(2-Methoxyphenoxy)benzaldehyde(cas: 66855-92-3).Reference of 3-(2-Methoxyphenoxy)benzaldehyde

The Article related to ccr8 antagonist preparation sar herg channel, Pharmacology: Structure-Activity and other aspects.Reference of 3-(2-Methoxyphenoxy)benzaldehyde

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On July 31, 2021, Koparan, Arzu; Gokalp, Mine published an article.Formula: C11H10O The title of the article was A Validated Method for Separation and Determination of Codeine Phosphate Hemihydrate Impurities in Bilayer Tablet Dosage Form of Naproxen Sodium and Codeine Phosphate by Using UHPLC. And the article contained the following:

Apranax Plus is a new bilayer tablet dosage form, which combines two active pharmaceutical ingredients: naproxen sodium and codeine phosphate. The purpose of this work was to develop an Ultra-High-Performance Liquid Chromatog. (UHPLC) method for the separation and determination of codeine phosphate hemihydrate impurities in a bilayer tablet dosage form. The separation and determination of codeine phosphate hemihydrate and its impurities, methylcodeine, morphine, codeine dimer, 10-hydroxycodeine, 14-hydroxycodeine, thebaine and codeinone were achieved by using reversed-phase liquid chromatog. with TUV (Tunable UV Detector) and PDA (Photodiode Array Detector) detection by UHPLC. The new proposed method utilized by the Waters Acquity UHPLC TUV and PDA systems using a UHPLC column Waters Acquity, BEH, C18, 2.1×100 mm, 1.7μm particle size with a mixture of component A and acetonitrile in a gradient mode at a flow rate of 0.3mL/min, at 25°C with a load of 5μL. The detection for all eluted compounds was carried out at 245nm. The codeine phosphate hemihydrate and peaks of its impurities were adequately obtained, thus proving the stability-indicating power of the method. The developed method was validated as per the ICH guidelines with respect to parameters such as precision, accuracy, linearity, Limit of Detection (LOD), Limit of Quantification (LOQ) and robustness. It was verified as being adequate for all the mentioned impurities of codeine phosphate hemihydrate. The described method was found to be useful for routine purity testing and was also found suitable for the anal. of the stability samples of the drug product. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Formula: C11H10O

The Article related to codeine phosphate hemihydrate naproxen sodium uhplc, Pharmaceutical Analysis: General and other aspects.Formula: C11H10O

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On May 1, 2012, Liu, Chang; Jin, Jing; Chen, Liang; Zhou, Jie; Chen, Xiaoguang; Fu, Decai; Song, Hongrui; Xu, Bailing published an article.Reference of 1-Fluoro-2-methoxybenzene The title of the article was Synthesis and biological evaluation of novel human Pin1 inhibitors with benzophenone skeleton. And the article contained the following:

A series of novel benzophenone derivatives were prepared and their inhibitory activities were evaluated on hPin1. Of all the synthesized compounds, the most active compound displayed inhibitory activities with an IC50 value of 5.99 μmol/L. Preliminary structure-activity relationships were analyzed in details and the binding mode of the titled compounds was predicted using FlexX algorithm. The results of this research will shed light on further design and optimization of novel small mol. Pin1 inhibitors. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Reference of 1-Fluoro-2-methoxybenzene

The Article related to benzophenone derivative preparation structure pin1 inhibitor, Pharmacology: Structure-Activity and other aspects.Reference of 1-Fluoro-2-methoxybenzene

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