On May 1, 2012, Liu, Chang; Jin, Jing; Chen, Liang; Zhou, Jie; Chen, Xiaoguang; Fu, Decai; Song, Hongrui; Xu, Bailing published an article.Reference of 1-Fluoro-2-methoxybenzene The title of the article was Synthesis and biological evaluation of novel human Pin1 inhibitors with benzophenone skeleton. And the article contained the following:
A series of novel benzophenone derivatives were prepared and their inhibitory activities were evaluated on hPin1. Of all the synthesized compounds, the most active compound displayed inhibitory activities with an IC50 value of 5.99 μmol/L. Preliminary structure-activity relationships were analyzed in details and the binding mode of the titled compounds was predicted using FlexX algorithm. The results of this research will shed light on further design and optimization of novel small mol. Pin1 inhibitors. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Reference of 1-Fluoro-2-methoxybenzene
The Article related to benzophenone derivative preparation structure pin1 inhibitor, Pharmacology: Structure-Activity and other aspects.Reference of 1-Fluoro-2-methoxybenzene
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