Andre, Mathieu; Tarrit, Sebastien; Couret, Marie-Joelle; Galmier, Marie-Josephe; Debiton, Eric; Chezal, Jean-Michel; Mounetou, Emmanuelle published an article in 2013, the title of the article was Spacer optimization of new conjugates for a melanoma-selective delivery approach.Application of 929-37-3 And the article contains the following content:
In the search for more selective anticancer drugs, we designed and synthesized seven conjugates varying the structure of the linker connecting the 5-iodo-2′-deoxyuridine (IUdR) to the ICF 01012 melanoma-carrier for potential intratumoral specific drug release. Chem. and in vitro metabolic stability evaluations showed that, except for the ester conjugate (1), the ketal (2b), acetal (2a), carbonate (4) and carbamate (3) conjugates were compatible with our approach. The acetal (2a) and its PEGylated derivative (2c) were of particular interest for further in vivo development owing to their resp. pH-dependent stability and limited metabolic degradation in order to exploit the acidic subcellular environment of malignant melanocytes to trigger the release of therapeutics upon internalization in cells. The experimental process involved the reaction of 2-(2-(Vinyloxy)ethoxy)ethanol(cas: 929-37-3).Application of 929-37-3
The Article related to antitumor melanoma icf01012 iododeoxyuridine conjugate spacer, Pharmaceuticals: Pharmaceutics and other aspects.Application of 929-37-3
Referemce:
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Ether | (C2H5)2O – PubChem