Month: November 2022

Efficient and enantioselective total syntheses of heliannuols A and K was written by Kanematsu, Makoto;Soga, Kana;Manabe, Yuki;Morimoto, Sachie;Yoshida, Masahiro;Shishido, Kozo. And the article was included in Tetrahedron in 2011.Product Details of 100927-02-4 The following contents are mentioned in the article:

The second-generation enantioselective synthesis of (-)-heliannuol A (I) and the first enantioselective total synthesis of (-)-heliannuol K (II) via two routes have both been accomplished efficiently; (I, nine steps and 25% yield; II, seven steps and 47% yield). Highlights of our synthetic strategy include a substrate-controlled chirality transfer in the Lewis acid mediated Claisen rearrangement of the allyl aryl ether for the key construction of a tertiary stereogenic center at the benzylic position followed by, for I, ring-closing metathesis, diastereoselective epoxidation, and regioselective cleavage of the epoxide; and for II, ring-closing metathesis and conjugate reduction of the eight-membered enone. This study involved multiple reactions and reactants, such as 4-(Benzyloxy)-3-methylphenol (cas: 100927-02-4Product Details of 100927-02-4).

4-(Benzyloxy)-3-methylphenol (cas: 100927-02-4) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Product Details of 100927-02-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Densities, excess molar volumes, speeds of sound, and isothermal compressibilities for {2-(2-hexyloxyethoxy)ethanol+ n-alkanol} systems at temperatures between (288.15 and 308.15)K was written by Pal, Amalendu;Gaba, Rekha. And the article was included in Journal of Chemical Thermodynamics in 2008.SDS of cas: 112-59-4 The following contents are mentioned in the article:

The densities, ρ and the speeds of sound, u, for {2-(2-hexyloxyethoxy)ethanol (C₆E₂) + methanol, + 1-propanol, + 1-pentanol, and + 1-heptanol} were measured as a function of composition using an Anton-Paar DSA 5000 densimeter at temperatures (288.15, 293.15, 298.15, 303.15, and 308.15) K and atm. pressure over the whole concentration range. The ρ and u values were used to calculate excess molar volumes, V ^E, and excess molar isentropic compressibility, K^E_S,m, resp. Also, thermal expansivity, α, partial molar volume, V i , and partial molar volume of the components at infinite dilution,^–V_i0 , were calculated The variation of these properties with composition and temperature of the mixtures are discussed in terms of mol. interactions. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4SDS of cas: 112-59-4).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.SDS of cas: 112-59-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ring opening and skeletal reconstruction of 3-vinyl benzofuranone-chromone synthons: catalyst-free access to skeletally-diverse 2-pyridone and optically active imidazoline derivatives was written by Wang, Wei-Na;Liu, Ren-Ming;Zhang, Lei;Liu, Xiong-Li;Dai, Yi-Feng;Yu, Zhang-Biao;Peng, Li-Jun. And the article was included in Organic & Biomolecular Chemistry in 2022.Product Details of 109-85-3 The following contents are mentioned in the article:

Herein the first example of ring opening and skeletal reconstruction of 3-vinyl benzofuranone-chromones as versatile synthons, which could react with ammonia or primary aliphatic amines as binucleophiles, for the eco-friendly and atom-economical synthesis of diverse and functionalized 2-pyridones with potential biol. activity in good to excellent yields (77-93%) was reported. When using optically active 1,2-diphenylethylenediamine as the binucleophile, the in situ generated 2-pyridone intermediates were successfully transformed to novel optically active functionalized imidazoline derivatives with high efficiency (up to 87% yield). In particular, this was the first report on the catalyst-free intramol. cyclization occurring between an amide and a primary aliphatic amine for the construction of imidazoline mols. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Product Details of 109-85-3).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Product Details of 109-85-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

ortho- and meta-Selective C-H Activation and Borylation of Aromatic Aldehydes via in situ Generated Imines was written by Bisht, Ranjana;Chattopadhyay, Buddhadeb. And the article was included in Synlett in 2016.Formula: C14H19BO4 The following contents are mentioned in the article:

A ligand-controlled discovery of ortho and meta C-H borylation of aromatic aldehydes is described. In both cases, an amine is used and it was proposed that ortho borylation could be realized using tert-butylamine as the traceless protecting/directing group and meta borylation undergoes via an electrostatic interaction and a secondary interaction between the ligand of the iridium catalyst and the substrate. Remarkably, these electrostatic interactions and secondary B-N interactions offer a unique and unprecedented guiding factor for the meta-selective C-H activation/borylation of benzaldehydes. This is the first example for the C-H activation and functionalization where the ortho and meta position of a substrate has selectively been functionalized, which open a new chapter in electrophilic aromatic substitution. This study involved multiple reactions and reactants, such as 5-Methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde (cas: 1132669-90-9Formula: C14H19BO4).

5-Methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde (cas: 1132669-90-9) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Formula: C14H19BO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Pyridine-based chiral smectogens: effects of polar end groups on liquid crystal properties was written by Vardar, Deniz;Akdas Kilic, Huriye;Ocak, Hale;Jeannin, Olivier;Camerel, Franck;Eran, Belkiz Bilgin. And the article was included in Liquid Crystals in 2021.Formula: C13H12O2 The following contents are mentioned in the article:

In this study, novel chiral pyridine-based rod-like mesogens, consisting of a chloro or bromo group substituted pyridine head core which is connected to one or two aromatic rings through ester linkers and a flexible (S)-2-methylbutoxy or (S)-3,7-dimethyloctyloxy chiral end chain have been synthesized. The liquid crystal properties of new compounds were investigated by various exptl. techniques such as DSC, POM and SAXS. Depending of the nature of the halogen end group, the derivatives with two aromatic rings are non-mesogenic compounds whereas a smectic A phase (SmA) enantiotropically occurs for the members with three aromatic rings of the series. Addnl., chloro group substituted compound composed of three aromatic rings carrying a (S)-2-methylbutoxy end chain exhibits an enantiotropic chiral nematic phase (N*). This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Formula: C13H12O2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Formula: C13H12O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Pyridine-based chiral smectogens: effects of polar end groups on liquid crystal properties was written by Vardar, Deniz;Akdas Kilic, Huriye;Ocak, Hale;Jeannin, Olivier;Camerel, Franck;Eran, Belkiz Bilgin. And the article was included in Liquid Crystals in 2021.COA of Formula: C13H12O2 The following contents are mentioned in the article:

In this study, novel chiral pyridine-based rod-like mesogens, consisting of a chloro or bromo group substituted pyridine head core which is connected to one or two aromatic rings through ester linkers and a flexible (S)-2-methylbutoxy or (S)-3,7-dimethyloctyloxy chiral end chain have been synthesized. The liquid crystal properties of new compounds were investigated by various exptl. techniques such as DSC, POM and SAXS. Depending of the nature of the halogen end group, the derivatives with two aromatic rings are non-mesogenic compounds whereas a smectic A phase (SmA) enantiotropically occurs for the members with three aromatic rings of the series. Addnl., chloro group substituted compound composed of three aromatic rings carrying a (S)-2-methylbutoxy end chain exhibits an enantiotropic chiral nematic phase (N*). This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2COA of Formula: C13H12O2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.COA of Formula: C13H12O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Micronization of Three Active Pharmaceutical Ingredients Using the Rapid Expansion of Supercritical Solution Technology was written by Fang, Chun-Hao;Chen, Pei-Hua;Chen, Yan-Ping;Tang, Muoi. And the article was included in Chemical Engineering & Technology in 2020.Name: 4-Benzyloxyphenol The following contents are mentioned in the article:

The rapid expansion of supercritical solution (RESS) technol. was applied to recrystallize and micronize three active pharmaceutical ingredients (APIs) of monobenzone, ethylparaben, and kojic acid. All unprocessed (original) APIs had a large mean particle size over 200μm with wide particle size distribution. Supercritical carbon dioxide served as the solvent to extract each API in a high-pressure vessel. The nearly saturated supercritical solution was then expanded through a capillary spray nozzle to ambient pressure state. The APIs were recrystallized in a very short time period. The final API particles with submicron sizes were obtained with much less intensity of crystallinity. The optimal RESS process parameters and the improved result of the in vitro dissolution test for the API of ethylparaben are reported. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Name: 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Name: 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Micronization of Three Active Pharmaceutical Ingredients Using the Rapid Expansion of Supercritical Solution Technology was written by Fang, Chun-Hao;Chen, Pei-Hua;Chen, Yan-Ping;Tang, Muoi. And the article was included in Chemical Engineering & Technology in 2020.Recommanded Product: 4-Benzyloxyphenol The following contents are mentioned in the article:

The rapid expansion of supercritical solution (RESS) technol. was applied to recrystallize and micronize three active pharmaceutical ingredients (APIs) of monobenzone, ethylparaben, and kojic acid. All unprocessed (original) APIs had a large mean particle size over 200μm with wide particle size distribution. Supercritical carbon dioxide served as the solvent to extract each API in a high-pressure vessel. The nearly saturated supercritical solution was then expanded through a capillary spray nozzle to ambient pressure state. The APIs were recrystallized in a very short time period. The final API particles with submicron sizes were obtained with much less intensity of crystallinity. The optimal RESS process parameters and the improved result of the in vitro dissolution test for the API of ethylparaben are reported. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Recommanded Product: 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Rh-Catalyzed Highly Enantioselective Synthesis of Aliphatic Sulfonyl Fluorides was written by Moku, Balakrishna;Fang, Wan-Yin;Leng, Jing;Li, Linxian;Zha, Gao-Feng;Rakesh, K. P.;Qin, Hua-Li. And the article was included in iScience in 2019.Formula: C13H12O2 The following contents are mentioned in the article:

Rh-catalyzed, highly enantioselective (up to 99.8% ee) synthesis of aliphatic sulfonyl fluorides (R)/(S)-RCH(R¹)CH₂SO₂F (R = Ph, dibenzo[b,d]thiophen-4-yl, thiophen-3-yl, etc.; R¹ = naphthalen-1-yl, dibenzo[b,d]furan-4-yl, benzo[b]thiophen-3-yl, etc.) was accomplished. This protocol provides a portal to a class of novel 2-aryl substituted chiral sulfonyl fluorides, which are otherwise extremely difficult to access. This asym. synthesis has the feature of mild conditions, excellent functional group compatibility, and wide substrate scope (51 examples) generating a wide array of structurally unique chiral β-arylated sulfonyl fluoride (R)-2-(dibenzo[b,d]thiophen-4-yl)-2-phenylethanesulfonyl fluoride for sulfur(VI) fluoride exchange (SuFEx) click reaction and drug discovery. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Formula: C13H12O2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Formula: C13H12O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Quantification of bisacurone and curcuminoids in turmeric products by liquid chromatography coupled with tandem mass spectrometry was written by Miyazawa, Taiki;Higuchi, Ohki;Sasaki, Masato;Thi, Minh Tu Nguyen;Miyazawa, Teruo. And the article was included in Journal of Nutritional Science and Vitaminology in 2022.HPLC of Formula: 33171-05-0 The following contents are mentioned in the article:

Turmeric products have many useful physiol. functions and are widely used as health food and food ingredient. Here, we report the use of HPLC-ESI-MS/MS to simultaneously quantify bisacurone and three curcuminoids (curcumin, demethoxycurcumin, and bisdemethoxycurcumin) in turmeric products (high viscosity liquid, granular powder, tablet, and solution). The results showed that the standard values and measured values of curcumin in each product were almost same. Demethoxycurcumin and bisdeme-thoxycurcumin were contained in each products. Meanwhile, the content of bisacurone differed greatly among the products. In particular, the highest amount of bisacurone was found in the turmeric product A (high viscosity liquid, 9.48 g/100 g product). It would become important to consider the bisacurone content in turmeric products. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0HPLC of Formula: 33171-05-0).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.HPLC of Formula: 33171-05-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem