Category: 2930-05-4

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2930-05-4, name is 2-((Benzyloxy)methyl)oxirane, This compound has unique chemical properties. The synthetic route is as follows., name: 2-((Benzyloxy)methyl)oxirane

General procedure: To a CO2 balloon equipped 10 mL round-bottomed flask containing indium bromide (0.178 g, 0.5 mmol) was added triphenylphosphine (0.262 g, 1 mmol) at rt. Epoxide 1 (10 mmol) was added, and stirred at rt for 5 h. The reaction system is gas (CO2)-liquid (substrate) biphasic system. To the reaction mixture was added 10 mL of H2O. The mixture was extracted with Et2O (10 mL) for three times. The organic layer was dried over MgSO4. After filtration and evaporation, the corresponding carbonate 2 was obtained in almost pure form. Yield was determined by comparing the ratio of product to substrate in the 1H NMR spectrum of the crude mixture. CAS Nos. 2a: 40492-31-7, 2b: 108-32-7, 2c: 66675-43-2, 2d: 4427-92-3, 2e: 4427-96-7, 2f: 2463-45-8, 2g: 949-97-3, 2h: 13818-44-5. For example, spectral data for 2a: Purification was done by distillation under reduced pressure. bp 85 C/0.07 mm Hg; IR (neat) 2900, 1789, 1172 cm-1; 1H NMR (CDCl3) delta 3.43 (s, 3H, OCH3), 3.54 (dd, 1H, J = 3.9 and 11.2 Hz, one of MeOCH2), 3.67 (dd, 1H, J = 3.4 and 11.2 Hz, one of MeOCH2), 4.37 (dd, 1H, J = 6.3 and 8.3 Hz, one of OCH2), 4.51 (t, J= 8.3 Hz, 1H, one of OCH2), 4.80-4.88 (m, 1H, OCH); 13C NMR (CDCl3) delta 59.3, 66.0, 71.3, 75.0, 154.9; EIHRMS calcd for C5H8O4 132.0423, found 132.0420.

According to the analysis of related databases, 2930-05-4, the application of this compound in the production field has become more and more popular.

Related Products of 2930-05-4, These common heterocyclic compound, 2930-05-4, name is 2-((Benzyloxy)methyl)oxirane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: IL/DFNS NPs (5mg) and epoxide derivatives (1mmol) werecharged into the reactor vessel without using any co-solvent. The reactor vessel was placed under a constant pressure ofcarbon dioxide and then heated to 70C for 2h. Then thereactor was cooled to ambient temperature, and the resultingmixture was transferred to a 50mL round bottom flask.Upon completion, the progress of the reaction was monitoredby TLC when the reaction was completed, EtOH wasadded to the reaction mixture and the KCC-1/IL/HPW NPswas separated by filteration. Then the solvent was removedfrom solution under reduced pressure and the resulting productpurifed by recrystallization using n-hexane/ethyl acetate.

Statistics shows that 2-((Benzyloxy)methyl)oxirane is playing an increasingly important role. we look forward to future research findings about 2930-05-4.

Reference:
Article; Zhang, Pu; Zhiani, Rahele; Catalysis Letters; vol. 150; 8; (2020); p. 2254 – 2266;,
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These common heterocyclic compound, 2930-05-4, name is 2-((Benzyloxy)methyl)oxirane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C10H12O2

General procedure: Five-membered cyclic carbonates were synthesized from carbondioxide and the corresponding substrates (10 mmol) in the appropriatemolar ratios by using 5.83 mg (0.01 mmol) of Co(II)-1-mesityl-1,2,3-1H-triazole-4-carboxylate (Co-TCA) as a catalyst in combination with aco-catalyst (tetrabutylammonium bromide (TBAB), tetrabutylammoniumchloride (TBAC), DMAP (4-(dimethylamino)pyridine)and TBAI (tetrabutylammonium iodide)) which were transferred intothe reactor. The reactor was charged with the reaction mixture (catalyst,cocatalyst, and substrate) and was purged with CO2 for 3 times atroom temperature. The reactor was heated to 120 C in the oil bath andthen pressurized to 1 bar of CO2. After completion, the reactor wasslowly cooled to room temperature. The catalyst (Co-TCA) was directlyused for the consecutive reaction cycles to identify the further usabilityand stability of the catalyst. In addition, column chromatography wasexecuted to isolate the product from the reaction mixture using petroleumether/ethyl acetate mixture (3:1) as eluent. After performing thecolumn chromatography, the solvent was evaporated to obtain thetarget-isolated product and the yield. Then, the sample was analyzed by1H, 13C-NMR and FTIR (Figure S3, S5, S7, S9, S11, S13, S15, S17, S19,S21, S23, S25, S27) analysis.

The synthetic route of 2-((Benzyloxy)methyl)oxirane has been constantly updated, and we look forward to future research findings.

Reference:
Article; Suleman, Suleman; Younus, Hussein A.; Ahmad, Nazir; Khattak, Zafar A.K.; Ullah, Habib; Park, Jihae; Han, Taejun; Yu, Baoyi; Verpoort, Francis; Applied Catalysis A: General; vol. 591; (2020);,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2930-05-4, name is 2-((Benzyloxy)methyl)oxirane, This compound has unique chemical properties. The synthetic route is as follows., 2930-05-4

General procedure: To a mixture of epoxide (1 equiv) and NaN3 (1.5 equiv) in CH3CN-H2O (8:2, 10 mL) Montmorillonite K 10 (5% w/w) was added. The reaction mixture was stirred at 80C for a specified time as required to complete the reaction. After completion as indicated by TLC, the reaction mixture was then filtered, the filter pad was washed with CH3CN and the combined filtrates were evaporated. The reaction mixture was extracted with EtOAc, the combined organic layers were washed with H2O and brine, dried over anhydrous Na2SO4, and evaporated under reduced pressure. The crude product was then purified by column chromatography over silica gel using EtOAc/petroleum ether as eluent to provide the pure azido alcohol. Characterization data of all the products are shown below.

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Reference:
Article; Ch Ghosh, Keshab; Banerjee, Isita; Sinha, Surajit; Synthetic Communications; vol. 48; 22; (2018); p. 2923 – 2934;,
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Some common heterocyclic compound, 2930-05-4, name is 2-((Benzyloxy)methyl)oxirane, molecular formula is C10H12O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 2930-05-4

General procedure: In a 20 mL pressure tube (for volatile amines) was combined epoxide (1.0 mmol, 1.0 equiv) and amine (1.5 mmol, 1.5 equiv) 6.7 mL of reagent grade DMF. The reaction vessel fitted with a stirbar, sealed, and heated at 60C for 12 h after which the vessel was allowed to cool to ambient temperature (not necessary for reactions not ran in pressure vessels) before receiving deionized water (50 equiv) in one portion. The vessel was resealed and stirred at 60C for an additional 12 h. Solvent was removed on a rotary evaporator (22.5 mbar at 35C) and the crude residue loaded directly onto a silica gel column.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2930-05-4, its application will become more common.

Reference:
Article; Lizza, Joseph R.; Moura-Letts, Gustavo; Synthesis; vol. 49; 6; (2017); p. 1231 – 1242;,
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2930-05-4, name is 2-((Benzyloxy)methyl)oxirane, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 2930-05-4

General procedure: A 50mL sealed tube with a magnetic stirring bar was evacuated and backfilled will CO2 for three times, potassium organoaluminate (0.1mmol), (n-Bu)4NI (0.05mmol), epoxide (2.0mmol), and 1.0mL THF were added. The reaction mixture was stirred at 50C (heating mantle temperature) for 24h. The reaction was then quenched with H2O (10mL) and extracted with ethyl acetate (3¡Á15mL). The combined organic layers were dried over Na2SO4 and concentrated. The yields were determined by 1H NMR spectroscopy with trichloroethylene (90muL, 1mmol) as an internal standard. Then, the reaction mixture was purified on silica gel column chromatography (petroleum ether/EtOAc: 3/1). All cyclic carbonates were identified through comparisons with the corresponding 1H NMR, 13C NMR data reported in the literatures [7].

Statistics shows that 2930-05-4 is playing an increasingly important role. we look forward to future research findings about 2-((Benzyloxy)methyl)oxirane.

Reference:
Article; Guo, Zhiqiang; Yan, Leilei; Liu, Yaoming; Wu, Xiaoqin; Wei, Xuehong; Journal of Organometallic Chemistry; vol. 922; (2020);,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

2930-05-4, name is 2-((Benzyloxy)methyl)oxirane, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 2930-05-4

General procedure: A 50mL sealed tube with a magnetic stirring bar was evacuated and backfilled will CO2 for three times, potassium organoaluminate (0.1mmol), (n-Bu)4NI (0.05mmol), epoxide (2.0mmol), and 1.0mL THF were added. The reaction mixture was stirred at 50C (heating mantle temperature) for 24h. The reaction was then quenched with H2O (10mL) and extracted with ethyl acetate (3¡Á15mL). The combined organic layers were dried over Na2SO4 and concentrated. The yields were determined by 1H NMR spectroscopy with trichloroethylene (90muL, 1mmol) as an internal standard. Then, the reaction mixture was purified on silica gel column chromatography (petroleum ether/EtOAc: 3/1). All cyclic carbonates were identified through comparisons with the corresponding 1H NMR, 13C NMR data reported in the literatures [7].

Statistics shows that 2930-05-4 is playing an increasingly important role. we look forward to future research findings about 2-((Benzyloxy)methyl)oxirane.

Reference:
Article; Guo, Zhiqiang; Yan, Leilei; Liu, Yaoming; Wu, Xiaoqin; Wei, Xuehong; Journal of Organometallic Chemistry; vol. 922; (2020);,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

2930-05-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2930-05-4, name is 2-((Benzyloxy)methyl)oxirane belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: In a typical procedure, an admixture comprising of a solid cata-lyst (20 mg), an aryloxy epoxide (1 mmol) and an amine (1 mmol)were taken in a 5 mL screw capped vial and stirred vigorously fora given time period (monitored by TLC) under solvent free con-dition. At the end of the reaction, products amino alcohols wereobtained as viscous liquids or solids. Therefore, the reaction mix-ture was repeatedly washed with methanol (3 mL) and centrifuged.Methanol from the combined organic layer was evaporated underreduced pressure to get crude amino alcohol. A small sample of thecrude product was subjected to HPLC to find out regioselectivity,while rest of the reaction mixture was subjected to flash columnchromatography (hexane/ethyl acetate, 90:10) to get the majorregioisomer in pure form. The purified product was characterizedby1H and13C NMR, FTIR, Microanalysis and characterization datafor all the ring opening products are given in supporting informa-tion. The residue obtained from centrifugation was dried in air (1 h)and then in oven at 100C for 3 h to get back the catalyst (>97%recovery) for further use.

The synthetic route of 2930-05-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Shah, Arpan K.; Prathap, K. Jeya; Kumar, Manish; Abdi, Sayed H.R.; Kureshy, Rukhsana I.; Khan, Noor-ul H.; Bajaj, Hari C.; Applied Catalysis A: General; vol. 469; (2014); p. 442 – 450;,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2930-05-4 as follows. 2930-05-4

To a solution of LiAlH4 (7.56 g, 199 mmol) in anhydrous tetrahydrofuran (100 mL) was added a solution of 2-(benzyloxymethyl)oxirane (21.8 g, 132 mmol, 20.1 mL) in anhydrous tetrahydrofuran (300 mL) dropwise at 0 C. under nitrogen atmosphere. The mixture was then stirred for 1 hour. On completion, the reaction mixture was quenched with water (15 mL), then 15% sodium hydroxide solution (15 mL) was added, and the mixture was stirred for a further 15 minutes until no precipitate formed. Next, the inorganic salt precipitate was filtered off and the filter cake was washed with ethyl acetate (2¡Á100 mL). The combine organic phase was dried over anhydrous magnesium sulfate, filtered and concentrated in vacuo to give a residue. The residue was purified by silica gel chromatography (petroleum ether:ethyl acetate=2:1) to give the title compound (21.3 g, 96% yield) as a colorless oil. 1H NMR (400 MHz, CDCl3) delta 7.40-7.29 (m, 5H), 4.57 (s, 2H), 4.08-3.94 (m, 1H), 3.49 (dd, J=3.2, 9.2 Hz, 1H), 3.30 (dd, J=8.4, 9.2 Hz, 1H), 2.40 (d, J=2.4 Hz, 1H), 1.16 (d, J=6.4 Hz, 3H).

According to the analysis of related databases, 2930-05-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Kymera Therapeutics, Inc.; Mainolfi, Nello; Ji, Nan; Kluge, Arthur F.; Weiss, Matthew M.; Zhang, Yi; (1443 pag.)US2019/192668; (2019); A1;,
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Ether | (C2H5)2O – PubChem