Some common heterocyclic compound, 2930-05-4, name is 2-((Benzyloxy)methyl)oxirane, molecular formula is C10H12O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 2930-05-4
General procedure: In a 20 mL pressure tube (for volatile amines) was combined epoxide (1.0 mmol, 1.0 equiv) and amine (1.5 mmol, 1.5 equiv) 6.7 mL of reagent grade DMF. The reaction vessel fitted with a stirbar, sealed, and heated at 60C for 12 h after which the vessel was allowed to cool to ambient temperature (not necessary for reactions not ran in pressure vessels) before receiving deionized water (50 equiv) in one portion. The vessel was resealed and stirred at 60C for an additional 12 h. Solvent was removed on a rotary evaporator (22.5 mbar at 35C) and the crude residue loaded directly onto a silica gel column.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2930-05-4, its application will become more common.
Reference:
Article; Lizza, Joseph R.; Moura-Letts, Gustavo; Synthesis; vol. 49; 6; (2017); p. 1231 – 1242;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem