2930-05-4, name is 2-((Benzyloxy)methyl)oxirane, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 2930-05-4
General procedure: A 50mL sealed tube with a magnetic stirring bar was evacuated and backfilled will CO2 for three times, potassium organoaluminate (0.1mmol), (n-Bu)4NI (0.05mmol), epoxide (2.0mmol), and 1.0mL THF were added. The reaction mixture was stirred at 50C (heating mantle temperature) for 24h. The reaction was then quenched with H2O (10mL) and extracted with ethyl acetate (3¡Á15mL). The combined organic layers were dried over Na2SO4 and concentrated. The yields were determined by 1H NMR spectroscopy with trichloroethylene (90muL, 1mmol) as an internal standard. Then, the reaction mixture was purified on silica gel column chromatography (petroleum ether/EtOAc: 3/1). All cyclic carbonates were identified through comparisons with the corresponding 1H NMR, 13C NMR data reported in the literatures [7].
Statistics shows that 2930-05-4 is playing an increasingly important role. we look forward to future research findings about 2-((Benzyloxy)methyl)oxirane.
Reference:
Article; Guo, Zhiqiang; Yan, Leilei; Liu, Yaoming; Wu, Xiaoqin; Wei, Xuehong; Journal of Organometallic Chemistry; vol. 922; (2020);,
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