Category: ethers-buliding-blocks

Electric Literature of 2688-84-8, These common heterocyclic compound, 2688-84-8, name is 2-Phenoxyaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 1 L round bottom flask reactor 2-Phenoxyaniline (25.0, 0.135 mol), hydrochloric acid (30 ml) and water (150 ml) were added and the mixture was cooled to 0 C and stirred for 1 hour. 75 ml of an aqueous solution of sodium nitrite (11.2 g, 0.162 mol) was added dropwise to the reaction solution at the same temperature, followed by stirring for 1 hour. When 75 ml of an aqueous solution of potassium iodide (44.8 g, 0.270 mol) was added dropwise, the temperature of the reaction solution was dropped so that the temperature did not exceed 5 C. After stirring for 5 hours at room temperature, the reaction mixture was washed with an aqueous solution of sodium cyanosulfate and extracted with ethyl acetate and water. The organic layer was separated and concentrated under reduced pressure, followed by separation and purification by column chromatography to obtain Intermediate 5-a. (22.6 g, 56.5%).

Statistics shows that 2-Phenoxyaniline is playing an increasingly important role. we look forward to future research findings about 2688-84-8.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13940-96-0, name is 4-Phenoxybenzene-1,2-diamine, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 13940-96-0

20 ml of 6N HC1 was added to 1000 mg of 4-phenoxybenzene-l, 2-diamine in round bottom flask. Then add 500 pL of thioglycolicacid. This reaction mixture was refluxed for 4 hours. Excess solvent was evaporated under reduced pressure and to the remaining residue water (30 ml) was added and then extraction with ethyl acetate. The organic solvent was then dried over anhydrous MgS04 and evaporated under reduced pressure. The crude product was directly used in the next step without any further purification. LC.MS: m/z 257.06 (M+H)+.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 13940-96-0.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 22236-10-8, name is 4-(Difluoromethoxy)aniline, A new synthetic method of this compound is introduced below., Computed Properties of C7H7F2NO

General procedure: N-substituted benzylidene pyrrolidine dione (0.5 mol),0.6 mmol TBTU, and 0.6 mmol EDCI were dissolved in 2mL DCM and 0.75 mmol DIEA mixture solution and stirred for 30 min. Next, 0.5 mol of amine or methylamino acid in DCM (8 mL) solution was slowly added to the solution and stirred at room temperature for 4-10 h with the TLC monitoring reaction. After the reaction was complete, the resultant solution was washed with dilute hydrochloricacid and saturated sodium bicarbonate solution, then dried with anhydrous sodium sulfate, followed by column chromatography separation. The target product was obtained by crystallization.The yield ranged from 72 to 90%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4393-09-3, name is (2,3-Dimethoxyphenyl)methanamine, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C9H13NO2

(1) 2,3-Dimethoxybenzylamine (33.4 mg, 0.2 mmol), 3,4-dimethoxyphenylsulfide ylide (102.5 mg, 0.4 mmol), in a clean reactor,Dichloro(pentamethylcyclopentadienyl) ruthenium (III) dimer (6.18Mg, 0.01 mmol), silver acetate (6.67 mg, 0.04 mmol) and water (2 mL),Stir in a 100 C oil bath for 24 h.(2) After the reaction is completed, dichloromethane is added for extraction, and a dichloromethane layer is collected.The solvent was removed under reduced pressure.The residue was purified by silica gel column chromatography to give a yellow solid.The yield was 37%.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4393-09-3.

Electric Literature of 2357-52-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2357-52-0, name is 4-Bromo-2-fluoroanisole, This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 101 (2R)-1-(3-Fluorobiphenyl-4-yloxy)-4-(3-pyridyl)-2-butanol STR126 a) 3-Fluoro-4-methoxybiphenyl Prepared according to the method as described in Example 33a) from 4-bromo-2-fluoroanisole (1.0 g), benzeneboronic acid (0.6 g), tetrakis(triphenylphosphine)palladium(0) (0.12 g), toluene (15 ml), ethanol (3 ml) and aqueous sodium carbonate (2 M, 5 ml) with heating at 120 C. for 2 hours. After work up the residue was purified by chromatography over silica eluding with ethyl acetate:hexane (1:9) to give the sub-title compound as a white solid (0.99 g). m.p. 86-87 C. MS (EI) 202 (M)+ 1 H NMR (DMSO-d6) 7.65(2 H, dd); 7.55(1 H, dd); 7.5-7.4(3 H, m); 7.33(1 H, t); 7.25(1 H, t); 3.88(3 H, s).

The chemical industry reduces the impact on the environment during synthesis 4-Bromo-2-fluoroanisole. I believe this compound will play a more active role in future production and life.

Reference of 82830-49-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 82830-49-7, name is 2-Fluoro-1,4-dimethoxybenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Step A: A 3-neck 1-liter flask equipped with a low temperature thermometer, N2 line, and dropping funnel was charged with 1, 4-dimethoxy-2-fluorobenzene (20.42 g, 131 mmol). The solid was dissolved in distilled THE (450 mL) and cooled to an internal temperature of-74DEG C. A 2.5 M solution of n-BuLi in hexane (63 mL, 157 mmol) was subsequently added over 25 min. under N2 via a dropping funnel. The reaction was maintained at-75 DEGC for 30 min. , before adding solid sulfur (5.01 g, 157 mmol) in one portion. Nitrogen sparging of the reaction mixture was begun at this time and continued throughout the reaction. The internal temperature rose to-65 DEG C but quickly recooled to-75 DEG C. The reaction temperature was maintained at-75 DEG C for 30 min. At this time, the excess dry ice in the dry ice/acetone bath was removed and the reaction was allowed to slowly warm to-20 DEG C over 1.5 h. The reaction was quenched with 2 N HC1 with vigorous N2 bubbling until the color of the reaction turned pale yellow.The internal temperature of the reaction rose to 10 DEG C. The reaction was extracted with EtOAc. The organic layer was collected, washed with brine, dried over MgS04, filtered, and concentrated in vacuo. The yellow residue was purified by silica gel chromatography with 20% EtOAc/hexane as the eluant to give the desired product as a light yellow solid. 1H 600MHz NMR (CDC13) ppm (8) : 3.84 (s, 3H), 3.86 (s, 3H), 6.56 (dd, J=1.8 Hz, J=8.9 Hz, 1H), 6.70 (t, 1H).

The synthetic route of 2-Fluoro-1,4-dimethoxybenzene has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4316-51-2, name is 4-Methoxytriphenylamine, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C19H17NO

Take compound I-TPA (4.40 g, 12.04 mmol)And purified DMF (31 mL) was added to a 100 mL round bottom flask and stirred at room temperature for 30 min until the compound I-TPA was completely dissolved.N-bromosuccinimide (2.84 g, 16 mmol) in portionsJoin the system,Stir at room temperature for 5 h. After the reaction is terminated,Diluted with dichloromethane and extracted with saturated brine until the aqueous phase was clear.MergedMachine phase, concentrated to no droplets,Chloroform / petroleum ether = 1/4 (v / v) as a rinse agent,Purified by silica gel column chromatography,The product was dried to a white oil, which was Intermediate 2-3, the actual yield was 4.70 g, and the yield was 75%.

According to the analysis of related databases, 4316-51-2, the application of this compound in the production field has become more and more popular.

Synthetic Route of 261762-35-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 261762-35-0, name is 5-Bromo-1,2-difluoro-3-methoxybenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Compound 1d (30mg, 128.04mumol), 5-bromo-1,2-difluoro-3-methoxybenzene (34.27mg, 153.65mumol), Pd (OAc) 2 (5.74mg, 25.61mumol), BINAP ( 31.89mg, 51.22mumol) and Cs2CO3 (105.00mg, 320.11mumol) were added in 5mL toluene, heated under N2 protection to 90 for 5h. After the reaction was completed, it was filtered through celite, and the filtrate was spin-dried and subjected to flash column chromatography (eluent system B) to obtain compound 1e (20 mg).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-1,2-difluoro-3-methoxybenzene, other downstream synthetic routes, hurry up and to see.

78531-29-0, name is 1,3-Dimethoxypropan-2-amine, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 1,3-Dimethoxypropan-2-amine

General procedure: Example 6B (0.018 g, 0.05 mmol) was dissolved in acetonitrile (0.5 ml), and treated with potassium carbonate (0.021 g, 0.15 mmol) and 1 -(2-chloroethyl)pyrrolidine (0.017 g, 0.1 mmol). The reaction mixture was heated via microwave at 180 C for 30 minutes, concentrated in vacuo, and submitted to reverse-phase HPLC (as described in Example 6C) to provide the title compound.

The synthetic route of 78531-29-0 has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 36865-41-5, name is 1-Bromo-3-methoxypropane, molecular formula is C4H9BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 1-Bromo-3-methoxypropane

(R)-tert-Butyl 3-(1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate (7B) (9.95 mmol, 3.0 g) was added to a 200 mL round-bottomed flask equipped for stirring under nitrogen. DMF (50 mL) was added and the resultant solution was cooled to 0 C. with an ice bath. NaH (60% in mineral oil, 11.95 mmol, 0.478 g) was then added and the subsequent solution was allowed to stir under nitrogen for 0.5 hr. At this time 1-bromo-3-methoxypropane (12.44 mmol, 1.90 g) was added, the ice bath was removed and the reaction solution was allowed to warm to room temperature and stir fort hr. The reaction solution was then poured into ice-water, extracted with ethyl acetate, and washed once with saturated aqueous sodium chloride. The organic layer was collected and subsequently dried with anhydrous Na2SO4 and filtered. This filtrate was collected, concentrated, and dried in-vacuo affording a brown oil. This material was then purified by chromatography on silica gel (3-10% CH3OH in CH2Cl2) to afford (R)-tert-butyl 3-(1-(3-methoxypropyl)-1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate (7C) as a brown oil (9.63 mmol, 3.6 g, 96% yield). 1H NMR (400 MHz, DMSO-d6) delta ppm 1.55-1.71 (br.s., 1H) 1.79-1.88 (br.s., 1H) 2.04-2.13 (m, 4H) 2.74-2.88 (br.s., 1H) 2.98-3.38 (m, 7H) 4.21-4.39 (m, 3H) 7.22-7.28 (m, 2H) 7.34-7.40 (dd, 1H, 6.57 Hz, 2.02 Hz) 7.72-7.77 (dd, 1H, 6.57 Hz, 2.02 Hz). ESI-MS: m/z 374.4 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 36865-41-5, its application will become more common.