Synthetic Route of 261762-35-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 261762-35-0, name is 5-Bromo-1,2-difluoro-3-methoxybenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Compound 1d (30mg, 128.04mumol), 5-bromo-1,2-difluoro-3-methoxybenzene (34.27mg, 153.65mumol), Pd (OAc) 2 (5.74mg, 25.61mumol), BINAP ( 31.89mg, 51.22mumol) and Cs2CO3 (105.00mg, 320.11mumol) were added in 5mL toluene, heated under N2 protection to 90 for 5h. After the reaction was completed, it was filtered through celite, and the filtrate was spin-dried and subjected to flash column chromatography (eluent system B) to obtain compound 1e (20 mg).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-1,2-difluoro-3-methoxybenzene, other downstream synthetic routes, hurry up and to see.