Extracurricular laboratory: Synthetic route of 4-Methoxytriphenylamine

According to the analysis of related databases, 4316-51-2, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4316-51-2, name is 4-Methoxytriphenylamine, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C19H17NO

Take compound I-TPA (4.40 g, 12.04 mmol)And purified DMF (31 mL) was added to a 100 mL round bottom flask and stirred at room temperature for 30 min until the compound I-TPA was completely dissolved.N-bromosuccinimide (2.84 g, 16 mmol) in portionsJoin the system,Stir at room temperature for 5 h. After the reaction is terminated,Diluted with dichloromethane and extracted with saturated brine until the aqueous phase was clear.MergedMachine phase, concentrated to no droplets,Chloroform / petroleum ether = 1/4 (v / v) as a rinse agent,Purified by silica gel column chromatography,The product was dried to a white oil, which was Intermediate 2-3, the actual yield was 4.70 g, and the yield was 75%.

According to the analysis of related databases, 4316-51-2, the application of this compound in the production field has become more and more popular.