Electric Literature of 2357-52-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2357-52-0, name is 4-Bromo-2-fluoroanisole, This compound has unique chemical properties. The synthetic route is as follows.
EXAMPLE 101 (2R)-1-(3-Fluorobiphenyl-4-yloxy)-4-(3-pyridyl)-2-butanol STR126 a) 3-Fluoro-4-methoxybiphenyl Prepared according to the method as described in Example 33a) from 4-bromo-2-fluoroanisole (1.0 g), benzeneboronic acid (0.6 g), tetrakis(triphenylphosphine)palladium(0) (0.12 g), toluene (15 ml), ethanol (3 ml) and aqueous sodium carbonate (2 M, 5 ml) with heating at 120 C. for 2 hours. After work up the residue was purified by chromatography over silica eluding with ethyl acetate:hexane (1:9) to give the sub-title compound as a white solid (0.99 g). m.p. 86-87 C. MS (EI) 202 (M)+ 1 H NMR (DMSO-d6) 7.65(2 H, dd); 7.55(1 H, dd); 7.5-7.4(3 H, m); 7.33(1 H, t); 7.25(1 H, t); 3.88(3 H, s).
The chemical industry reduces the impact on the environment during synthesis 4-Bromo-2-fluoroanisole. I believe this compound will play a more active role in future production and life.