Tag: 100-200

On July 2, 1982, Brown, John M.; Parker, David published an article.Synthetic Route of 81616-80-0 The title of the article was Mechanism of asymmetric hydrogenation. Rhodium complexes formed by unsaturated carboxylic acids, carboxylates, and carboxamides. And the article contained the following:

��Unsaturated acids displace solvent from (R,R)-I (L = MeOH) cation, forming chelate complexes in which olefin and carboxylate are bound to the metal. The strength of complexation is enhanced in basic media and propenoic or 2-methylpropenoic acid form a different type of species with 2:1 stoichiometry in the absence of base. ��And ��unsaturated amides likewise form complexes in which olefin and carboxamide O are bound to Rh. The ratio of diastereomers observed by 31P NMR does not correlate with optical yields in hydrogenation of these precursors. In related experiments with (R,R)-[1,2-bis(o-anisylphenylphosphino)ethane]bis(methanol)rhodium cation, 2-methylenesuccinic acid and its Me esters gave a variety of complexes, including tridentate species where both carboxyl groups and olefin were concomitantly bound. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).Synthetic Route of 81616-80-0

The Article related to asym hydrogenation rhodium complex, rhodium carboxylate carboxamide complex, olefin rhodium complex, Organometallic and Organometalloidal Compounds: Group Viii – Co, Ni, Ru, Rh, Pd, Os, Ir, Pt and other aspects.Synthetic Route of 81616-80-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On February 20, 2013, Fier, Patrick S.; Luo, Jingwei; Hartwig, John F. published an article.Category: ethers-buliding-blocks The title of the article was Copper-Mediated Fluorination of Arylboronate Esters. Identification of a Copper(III) Fluoride Complex. And the article contained the following:

A method for the direct conversion of arylboronate esters to aryl fluorides under mild conditions with readily available reagents is reported. Tandem reactions have also been developed for the fluorination of arenes and aryl bromides through arylboronate ester intermediates. Mechanistic studies suggest that this fluorination reaction occurs through facile oxidation of Cu(I) to Cu(III), followed by rate-limiting transmetalation of a bound arylboronate to Cu(III). Fast C-F reductive elimination is proposed to occur from an aryl-copper(III)-fluoride complex. Cu(III) intermediates have been generated independently and identified by NMR spectroscopy and ESI-MS. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Category: ethers-buliding-blocks

The Article related to copper catalyzed fluorination arylboronate ester mechanism, tandem fluorination arene aryl bromide, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Halides and Halonium Compounds and other aspects.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Font, Marc; Spencer, Andrew R. A.; Larrosa, Igor published an article in 2018, the title of the article was meta-C-H arylation of fluoroarenes via traceless directing group relay strategy.Product Details of 321-28-8 And the article contains the following content:

While several methods for the ortho selective arylation of fluoroarenes, meta-functionalization has never been achieved. We report a new methodol., based on the traceless directing group relay concept, leading to the first meta-selective (hetero)arylation of fluoroarenes. In this strategy, CO2 is introduced as a transient directing group, to control a Pd-catalyzed arylation meta to the fluoro functionality, prior to its release in a sequential, one-pot fashion. This method has shown compatibility with a number of functional groups and substitution patterns in both the fluoroarene core and aryl iodide coupling partners, and proceeds with complete meta-selectivity and mono vs. bis-arylation selectivity. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Product Details of 321-28-8

The Article related to fluoro biaryl preparation regioselective, aryl fluoride aryl iodide arylation decarboxylation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Halides and Halonium Compounds and other aspects.Product Details of 321-28-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On February 6, 2015, Fujimoto, Teppei; Ritter, Tobias published an article.Name: 1-Fluoro-2-methoxybenzene The title of the article was PhenoFluorMix: Practical Chemoselective Deoxyfluorination of Phenols. And the article contained the following:

A practical deoxyfluorination with novel deoxyfluorinating reagent PhenoFluorMix, a mixture of N,N’-1,3-bis(2,6-diisopropylphenyl)chloroimidazolium chloride and CsF, is presented. PhenoFluorMix overcomes the challenges associated with hydrolysis of PhenoFluor. PhenoFluorMix does not hydrolyze, is readily available on decagram scale, and is storable in air. In this paper, we demonstrate the practicality of the reagent and exhibit the deoxyfluorination of a variety of phenols and heterocycles. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Name: 1-Fluoro-2-methoxybenzene

The Article related to aryl halide chemoselective synthesis, phenol heterocycle deoxyfluorination phenofluormix, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Halides and Halonium Compounds and other aspects.Name: 1-Fluoro-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On October 7, 2020, Pistritto, Vincent A.; Schutzbach-Horton, Megan E.; Nicewicz, David A. published an article.Category: ethers-buliding-blocks The title of the article was Nucleophilic Aromatic Substitution of Unactivated Fluoroarenes Enabled by Organic Photoredox Catalysis. And the article contained the following:

Nucleophilic aromatic substitution (SNAr) is a classical reaction with well-known reactivity toward electron-poor fluoroarenes. However, electron-neutral and electron-rich fluoro(hetero)arenes are considerably underrepresented. Herein, we present a method for the nucleophilic defluorination of unactivated fluoroarenes enabled by cation radical-accelerated nucleophilic aromatic substitution. The use of organic photoredox catalysis renders this method operationally simple under mild conditions and is amenable to various nucleophile classes, including azoles, amines, and carboxylic acids. Select fluorinated heterocycles can be functionalized using this method. In addition, the late-stage functionalization of pharmaceuticals is also presented. Computational studies demonstrate that the site selectivity of the reaction is dictated by arene electronics. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Category: ethers-buliding-blocks

The Article related to nucleophilic aromatic substitution unactivated fluoroarene organic photoredox catalysis, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Halides and Halonium Compounds and other aspects.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On March 31, 2015, Dubbaka, Srinivas Reddy; Gadde, Satyanarayana; Narreddula, Venkateswara Reddy published an article.SDS of cas: 321-28-8 The title of the article was Synthesis of Aryl Fluorides from Potassium Aryltrifluoroborates and Selectfluor Mediated by Iron(III) Chloride. And the article contained the following:

The synthesis of fluorinated arenes by the iron-mediated fluorination of potassium aryltrifluoroborates with Selectfluor and potassium fluoride is described. The fluorination reaction uses com. available reagents and without requiring the addition of exogenous ligands. Fluorinated compounds were obtained in moderate to good yields under mild reaction conditions. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).SDS of cas: 321-28-8

The Article related to aryl fluoride preparation aryltrifluoroborate fluorination selectfluor iron trichloride, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Halides and Halonium Compounds and other aspects.SDS of cas: 321-28-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On October 4, 2013, Ichiishi, Naoko; Canty, Allan J.; Yates, Brian F.; Sanford, Melanie S. published an article.Computed Properties of 321-28-8 The title of the article was Cu-Catalyzed Fluorination of Diaryliodonium Salts with KF. And the article contained the following:

A mild Cu-catalyzed nucleophilic fluorination of unsym. diaryliodonium salts with KF is described. This protocol preferentially fluorinates the smaller aromatic ligand on iodine(III). The reaction exhibits a broad substrate scope and proceeds with high chemoselectivity and functional group tolerance. E.g., in presence of Cu(OTf)2 and 18-crown-6, nucleophilic fluorination of diaryliodonium salt (I) with KF gave 85% II and mesityl fluoride (99:1). DFT calculations implicate a CuI/CuIII catalytic cycle. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Computed Properties of 321-28-8

The Article related to copper catalyst nucleophilic fluorination diaryliodonium salt potassium fluoride, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Halides and Halonium Compounds and other aspects.Computed Properties of 321-28-8

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On February 21, 2020, Granados, Albert; Shafir, Alexandr; Arrieta, Ana; Cossio, Fernando P.; Vallribera, Adelina published an article.COA of Formula: C8H10O2 The title of the article was Stepwise Mechanism for the Bromination of Arenes by a Hypervalent Iodine Reagent. And the article contained the following:

A mild, metal-free bromination method of arenes has been developed using the combination of bis(trifluoroacetoxy)iodobencene and trimethylsilyl bromide. In situ-formed dibromo(phenyl)-ä½?-iodane (PhIBr2) is proposed as the reactive intermediate. This methodol. using PIFA/TMSBr has been applied with success to a great number of substrates (25 examples). The treatment of mono-substituted activated arenes led to para-brominated products (2u-z) in excellent 83-96% yields. D. functional theory calculations indicate a stepwise mechanism involving a double bromine addition followed by a type II dyotropic reaction with concomitant re-aromatization of the six-membered ring. The experimental process involved the reaction of 1,4-Dimethoxybenzene(cas: 150-78-7).COA of Formula: C8H10O2

The Article related to arene bromination stepwise mechanism hypervalent iodine reagent, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Halides and Halonium Compounds and other aspects.COA of Formula: C8H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem