On February 21, 2020, Granados, Albert; Shafir, Alexandr; Arrieta, Ana; Cossio, Fernando P.; Vallribera, Adelina published an article.COA of Formula: C8H10O2 The title of the article was Stepwise Mechanism for the Bromination of Arenes by a Hypervalent Iodine Reagent. And the article contained the following:
A mild, metal-free bromination method of arenes has been developed using the combination of bis(trifluoroacetoxy)iodobencene and trimethylsilyl bromide. In situ-formed dibromo(phenyl)-ä½?-iodane (PhIBr2) is proposed as the reactive intermediate. This methodol. using PIFA/TMSBr has been applied with success to a great number of substrates (25 examples). The treatment of mono-substituted activated arenes led to para-brominated products (2u-z) in excellent 83-96% yields. D. functional theory calculations indicate a stepwise mechanism involving a double bromine addition followed by a type II dyotropic reaction with concomitant re-aromatization of the six-membered ring. The experimental process involved the reaction of 1,4-Dimethoxybenzene(cas: 150-78-7).COA of Formula: C8H10O2
The Article related to arene bromination stepwise mechanism hypervalent iodine reagent, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Halides and Halonium Compounds and other aspects.COA of Formula: C8H10O2
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