On October 7, 2020, Pistritto, Vincent A.; Schutzbach-Horton, Megan E.; Nicewicz, David A. published an article.Category: ethers-buliding-blocks The title of the article was Nucleophilic Aromatic Substitution of Unactivated Fluoroarenes Enabled by Organic Photoredox Catalysis. And the article contained the following:
Nucleophilic aromatic substitution (SNAr) is a classical reaction with well-known reactivity toward electron-poor fluoroarenes. However, electron-neutral and electron-rich fluoro(hetero)arenes are considerably underrepresented. Herein, we present a method for the nucleophilic defluorination of unactivated fluoroarenes enabled by cation radical-accelerated nucleophilic aromatic substitution. The use of organic photoredox catalysis renders this method operationally simple under mild conditions and is amenable to various nucleophile classes, including azoles, amines, and carboxylic acids. Select fluorinated heterocycles can be functionalized using this method. In addition, the late-stage functionalization of pharmaceuticals is also presented. Computational studies demonstrate that the site selectivity of the reaction is dictated by arene electronics. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Category: ethers-buliding-blocks
The Article related to nucleophilic aromatic substitution unactivated fluoroarene organic photoredox catalysis, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Halides and Halonium Compounds and other aspects.Category: ethers-buliding-blocks
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