Tag: M.W=100-200

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2734-70-5, name is 2,6-Dimethoxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Formula: C8H11NO2

Weigh 0.5 mmol of amide III-1, 1percent molar amount of palladium catalyst, 1 mmol of potassium carbonate, 0.75 mmol of 2,5-dimethoxyaniline in a Schlenk reaction tube, double-tube tube was purged with nitrogen, repeated three times, and then opened again. Nitrogen valve, add 2 ml of freshly distilled tetrahydrofuran, and close the valve. The tube was stirred at room temperature for 10 minutes and then placed at 110 ° C for 24 hours. After the completion of the reaction, TLC was plated, THF was evaporated, water was added, and water was added, and the mixture was extracted three times with ethyl acetate, and dried over anhydrous magnesium sulfate, and then evaporated to dryness to give the product white crystals: 0.385 mmol (104.5 mg). The product was N-(2,6-dimethoxyphenyl)-3-methylbenzamide in 77percent yield.

The synthetic route of 2734-70-5 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 39538-68-6, name is 2-Methoxy-4-methylaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39538-68-6, Recommanded Product: 2-Methoxy-4-methylaniline

Intermediate 43Preparation of 1-bromo-2-methoxy-4-methylbenzeneTo a solution of copper(II)bromide (6.35 g; 28.4 mmol) in acetonitrile (25 mL) was added tert-butyl nitrite (2.85 ml; 24.06 mmol) and the mixture was heated at 65 C. under nitrogen atmosphere. A solution of 2-methoxy-4-methylaniline (3 g, 21.87 mmol) in 25 ml acetonitrile was added carefully and the mixture was stirred for 20 min at 65 C. The solvent was removed under reduced pressure, the residue was dissolved in ethyl acetate and washed with a 5% solution of ammonia, water, a solution of EDTA, water and brine. The organic layer was dried over sodium sulphate, filtered and concentrated under reduced pressure. Purification by flash chromatography on silica gel using a gradient of ethyl acetate (2-50%) in heptane furnished 2.32 g (53%) of the title compound. 1H-NMR (300 MHz, CDCl3) (ppm) delta: 6.63-6.60 (m, 3H, 3×Harom.); 3.82 (s, 3H, OCH3); 2.26 (s, 3H, CH3).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methoxy-4-methylaniline, other downstream synthetic routes, hurry up and to see.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4393-09-3 as follows. Computed Properties of C9H13NO2

General procedure: To a solution of the acid derivative (1mmol) in CH2Cl2 were added triethylamine (2mmol) and ethyl chloroformate (1mmol), followed by stirring at 0C for 30min. After addition of the appropriate amine derivative (1.2mmol), the mixture was stirred for an additional 1h at 0C. Then, the reaction mixture was warmed to room temperature and stirred overnight. After the solvent was evaporated under reduced pressure, acetone was added, filtered, and evaporated. The residue was dissolved in CH2Cl2, and the organic phase was washed with a 1% NaHCO3 solution and brine, dried over Na2SO4, and evaporated under vacuum. The final residue was purified by flash column chromatography (Combiflash Rf) using CH2Cl2-MeOH (0-5%) as eluents. 4.3.8 (E)-N-(2,3-Dimethoxybenzyl)-3-(1H-indol-3-yl)acrylamide 3h Yield 69%, mp 211-213 C; IR (FTIR/FTNIR-ATR): 1639 cm-1 (C=O), 3206 cm-1 (N-H). 1H NMR (DMSO-d6) delta: 11.56 (1H, s), 8.21 (1H, t, J = 5.6 Hz), 7.91 (1H, d, J = 7.6 Hz), 7.75 (1H, s), 7.63 (1H, d, J = 15.6 Hz), 7.45 (1H, d, J = 7.6 Hz), 7.18 (2H, m), 6.88 (3H, m), 6.71 (1H, d, J = 16 Hz), 4.40 (2H, d, J = 6 Hz), 3.80 (3H, s), 3.76 (3H, s). 13C NMR (DMSO-d6) delta: 166.9, 152.9, 146.9, 138.0, 133.8, 133.5, 131.0, 125.5, 124.5, 122.8, 121.1, 120.9, 120.6, 116.8, 112.9, 112.8, 112.3, 60.8, 56.3, 37.7; HRMS C20H21N2O3 [M+H]+ Calcd 337.1552, Found m/z 337.1544.

According to the analysis of related databases, 4393-09-3, the application of this compound in the production field has become more and more popular.

Synthetic Route of 145903-31-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 145903-31-7, name is 7-Methoxy-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Synthesis of S13 and S14 (Scheme 5): To S26 (20 mg, 0.1 mmol) in CH2Cl2 (5 ml) is added triethylamine (30 mg, 0.3 mmol) and phenyl methoxyphosphonyl chloride (38 mg, 0.2 mmol) at 0 C. After stirring for 2 hours at room temperature, the reaction mixture is washed with saturated sodium bicarbonate. Isomers are separated and purified by silica gel column to yield S13 (14 mg, yield: 40%) and S14 (16 mg, yield: 45%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7-Methoxy-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine, other downstream synthetic routes, hurry up and to see.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 450-91-9, name is 4-Fluoro-2-methoxyaniline, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 450-91-9

In a dry round bottom flask acetic acid (950 ml) and 4-fluoro-2-methoxyaniline (380 gms) were added. The reaction mass was stirred at 25-30°C for 10-15 minutes. Acetic anhydride (439 gms) was added slowly to the reaction mass at 25- 35°C in 1.0-2.0 hrs. The reaction mass was heated to 90°C and stirred at same temperature for 3.0-5.0 hrs. The reaction mass was decomposed into water (1000 ml) and stirred at 25-30°C for 1.0-2.0 hrs. The solid was filtered and washed with water (300 ml). The reaction mass was extracted with ethyl acetate (2000 ml). Total organic layers were washed with NaHC03 solution (NaHC03 (100 gms) + water-4 (500 ml)) followed by washed with water (1000 ml), then washed with brine solution (NaCl (50 gms) + water-6(250 ml)) and dried over sodium sulphate (200 gms). The solvent was distilled out under vacuum. Petroleum ether (500 ml) was added to the residue and cooled to below 10°C and stirred for 30 minutes. The solid was filtered off and washed with petroleum ether (150 ml). The solid was dried at 50-60°C for 3-5 hrs (Yield – 410 gms; 83.13percent).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 450-91-9.

Application of 102503-23-1, The chemical industry reduces the impact on the environment during synthesis 102503-23-1, name is 1-(2,4-Dimethoxyphenyl)-N-methylmethanamine, I believe this compound will play a more active role in future production and life.

Vinylmagnesium bromide (17.7 mL of a IN solution in THF, 17.7 mmol) was added to a solution of 5 (2.00 g, 8.84 mmol) in dry THF (30 mL) at 0 C. The brown solution was warmed to r.t. for 1 h then a solution of N-methyl-2,4-dimethoxybenzylamine (4.00 g, 22.0 mmol) in THF (10 mL), and water (10 mL) were added. The solution was stirred at r.t. for 1 h, then partitioned between EtOAc and water. The solution was dried and evaporated to give a brown oil, which was chromatographed. Elution with EtOAc/hexanes gave fore fractions, then elution with EtOAc gave 7 (2.27 g, 68%) as a light yellow oil. 1H NMR (CDC13) delta 7.13 (d, J = 8.9 Hz, 1H), 6.73 (s, 2H), 6.44-6.41 (m, 2H), 3.59 (s, 6H), 3.88 (s, 3H), 3.53 (s, 3H), 3.50 (s, 2H), 3.12 (t, J = 7.0 Hz, 1H), 2.84 (t, J = 7.0 Hz, 2H), 2.26 (s, 3H). Found: [M+H]=375.3

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(2,4-Dimethoxyphenyl)-N-methylmethanamine, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 3616-56-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3616-56-6, name is 2,2-Diethoxy-N,N-dimethylethanamine, This compound has unique chemical properties. The synthetic route is as follows.

Synthesis Example B2Synthesis of 12H-benzofuranyl[2,3-a]carbazole (compound 2)Compound 1 (2.0 g, 1 eq.) is added to acetic acid (90 ml) and heated to reflux. (Dimethylamino)acetaldehyde diethyl acetal (95percent; 14.6 g, 10 eq.) is added dropwise in portions to the solution.The reaction is stirred at reflux until no reactant is present any longer.Subsequently, the flask contents are diluted with CH2Cl2 at room temperature and washed in a separating funnel with distilled water and NaCl (saturated).Organic phase is dried with Na2SO4 and concentrated. LC (SiO2, 15:85 CH2Cl2/n-hex) gives the product 2 (0.85 g, 39percent yield).1H NMR (CD2Cl2, 400 MHz): delta=8.68 (br s, 1H), 8.15 (d, 1H), 8.06 (dd, 2H), 7.83 (d, 1H), 7.67 (d, 1H), 7.59 (d, 1H), 7.47 (dd, 2H), 7.41 (dd, 1H), 7.30 (dd, 1H).

The chemical industry reduces the impact on the environment during synthesis 2,2-Diethoxy-N,N-dimethylethanamine. I believe this compound will play a more active role in future production and life.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 89282-70-2, name is 2-Methoxy-2-methylpropan-1-amine, A new synthetic method of this compound is introduced below., Safety of 2-Methoxy-2-methylpropan-1-amine

A mixture of phenyl 5-[(trans-4-{[2-chloro-5-(morpholin-4-yl)phenyl]carbamoyl}cyclohexyl)carbamoyl]-1 H-imidazole-4-carboxylate (100 mg, 0.181 mmol,) and 2-methoxy-2-methylpropan-1 -amine (93 mg, 0.906 mmol, GAS No 89282-70-2) in tetrahydrofuran (4.6 ml) was stirred at 60CC ove r night. For work-up the reaction mixturewas concentrated and purified by preparative HPLG (Method 9) to yield the title compound (5.2 mg, 5% yield).LG-MS (Method 6): R = 1 .08 mm; MS (ESIpos) m/z = 561 .3 [M÷H]. 1HNMR (400 MHz, DMSO-d6): 6 [ppm] = 10.07-9.57 (m, 1H), 9.51-9.04 (m, 2H), 7.35-7.11(m, 3H), 6.81 -6.76 (m, 1H), 3.82-3.61 (m, 5H), 3.15 (s, 3H), 3.13-3.03 (m, 4H), 2.02-1.86 (m,4H), 1.62-1.43 (m, 2H), 1.42-1.27 (m, 2H), 1.13 (s, 6H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 6781-17-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6781-17-5, name is 2-(2-Ethoxyphenoxy)ethanamine, This compound has unique chemical properties. The synthetic route is as follows.

(a) Synthesis of Oxalate Salt of Racemic Tamsulosin 2-(o-Ethoxyphenoxy)ethylamine (45 gm) was dissolved in methanol (250 mL). To this 2-methoxy-5-(2-oxopropyl)-benzene sulfonamide (55 gm), catalyst 5% platinum on carbon (12.1 gm) and methanol (330 mL) were added. The mixture was hydrogenated in autocalve at 55 C. at hydrogen pressure of 13 kg/cm2 for 5 hrs. The reaction mixture was cooled and the catalyst was filtered off. To the filtrate containing racemic tamsulosin, oxalic acid (14.3 gm) was added and the solvent was distilled off. To the residue, acetone (700 mL) was added and stirred at reflux temperature for 30 mins. The mixture was cooled, filtered, and the filter cake washed with acetone (50 mL). The salt was further purified by suspending the material in 2-propanol at reflux temperature, cooling to ambient temperature and filtering the solid. The pure oxalate salt of racemic tamsulosin shows a melting range of: 178-182 C. and HPLC purity: 97.24 (area %). The chiral HPLC showed it to be a mixture R and S isomers in the ratio of 50.1 to 49.9. The infrared spectrum of the oxalate salt of racemic tamsulosin as shown in of the drawing accompanying this specification, exhibited peaks at cm-1: 1154 & 1332 (SO2), 3408 (-NH2), 2983 (NH2+), 1591 (COO-). The 1H-NMR spectrum in CD3SOCD3 gave signals at 8 values: 1.06-1.08 (3H, d, >CH-), 1.30-1.33 (3H, t, -CH2-), 3.89 (3H, s, -O), 4.15-4.36 (10 H, 4-CH2, -CH, -NH), 7.61 (2H, s, -NH2), 6.8-7.5 (7H, m, Ar-H). The 13C-NMR spectrum exhibited signals as expected, in particular at delta values 56.34 (-OH3), 14.93 (-OCH2H3), 17.29 (-CH.H3), 54.59 (-H.CH3), 64.11 (-OH2.CH3), 44.51 (-NH.H2.CH2.CH2.O-), 67.25 (-NH.CH2.H2.O-), 39.53 (-H2.CH-), 165.35 (COOH oxalate). Element analysis: C=53.64% (Calcd. 53.49%), H=6.57% (Calcd. 6.62%), N=5.89% (Calcd. 5.95%) and S=6.58% (Calcd. 6.79%) and corresponds to the hydrate, M.Wt. 471.53, C21H29N2O7S.H2O. The ES-mass spectrum signal at m/z=409 corresponded to mass of free base. The XRD trace shows strong peaks at 2 theta values: 20.36, 22.33, 14.8, and 13.74 in that sequence as shown in . The DSC thermogram of pure salt exhibited a sharp peak at 180.2 C. as shown in

The chemical industry reduces the impact on the environment during synthesis 2-(2-Ethoxyphenoxy)ethanamine. I believe this compound will play a more active role in future production and life.

Synthetic Route of 24599-58-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 24599-58-4 as follows.

2-Bromo-5-methylcyclohexa-2,5-diene-1,4-dione (23). To a solution of toluquinol (1) (2.5 g, 20.14mmol,1.0 equiv.) in acetone (15 mL) was added K2CO3 (14 g, 100.70 mmol, 5.0 equiv.) and Me2SO4 (5.7 mL,60.41 mmol, 3.0 equiv.) and the reaction mixture was stirred for 3 h. After this time, the reactionmixture was diluted with water and the aqueous phase was extracted with Et2O. The organic phasewas washed with brine, dried over MgSO4, filtered, and the solvent removed under reduced pressureto obtain the corresponding dimethoxy derivative (~20 mmol), which was used in the next stepswithout purification. To a solution of the dimethoxy derivative obtained above (~20 mmol) and NaOAc(3.3 g, 40.28 mmol, 2.0 equiv.) in AcOH (20 mL) was added bromine (1.2 mL, 2.15 mmol, 1.1 equiv.)over 25 min and, after the addition, the reaction mixture was stirred for 1 h. Then, the reaction mixturewas quenched by a slow addition of a saturated aqueous NaHCO3 solution at 0 C. The aqueousphase was then extracted with EtOAc and the organic phase washed with brine, dried over MgSO4,ltered, and the solvent removed under reduced pressure to obtain the corresponding bromo derivative(~20 mmol), which was used in the next step without purication. The bromo derivative obtainedabove (~20 mmol) was dissolved in CH3CN (35 mL). Then, CAN (28 g, 50.34mmol, 2.5 equiv.) and H2O(20 mL) were added and the reaction mixture was stirred for 1 h at 25 C. After this time, the reactionmixture was diluted with water and the aqueous phase was extracted with Et2O twice. The combinedorganic phases were washed with brine, dried over MgSO4, filtered, and the solvent removed underreduced pressure. The residue was purified by flash column chromatography (silica gel, 1% EtOAc inhexanes) to obtain compound 23 (1.5 g, 37% over 3 steps) as an orange solid [13]: Rf = 0.45 (silica gel,20% EtOAc in hexanes); 1H NMR (400 MHz, CDCl3) delta 7.29 (s, 1 H), 7.26 (s, 2 H), 2.08 (d, J = 1.6 Hz,3 H); 13C NMR (100 MHz, CDCl3) delta 185.1, 179.5, 146.5, 138.1, 137.5, 132.6, 15.7.

According to the analysis of related databases, 24599-58-4, the application of this compound in the production field has become more and more popular.