Month: October 2022

Application In Synthesis of 2-MethoxybenzaldehydeIn 2019 ,《Preparation and characterization of an eco-friendly ZnFe2O4@alginic acid nanocomposite catalyst and its application in the synthesis of 2-amino-3-cyano-4H-pyran derivatives》 appeared in Polyhedron. The author of the article were Maleki, Ali; Varzi, Zahra; Hassanzadeh-Afruzi, Fereshte. The article conveys some information:

The ZnFe2O4@alginic acid nanocomposite was synthesized by a simple procedure. Then, it was utilized as a green, cost-effective and heterogeneous catalyst in the synthesis of 2-amino-3-cyano-4H-pyran derivatives I (R = H, 2-NO2, 3-MeO, 4-OH, etc.) with a one-pot three-component reaction between various aromatic aldehydes RC6H4CHO, dimedone and malononitrile. Conventional methods such as Fourier transform IR (FT-IR) spectroscopy, X-ray diffraction (XRD) pattern, SEM (SEM) image, energy-dispersive X-ray (EDX) anal., vibrating sample magnetometer (VSM) curve and inductively-coupled plasma at. emission spectroscopy (ICP-AES) anal. were employed to characterize the prepared nanocomposite. This protocol offers some beneficial features such as green catalyst, mild reaction conditions, simple procedure, easy workup, short reaction times and significant yield of the products I. The magnetic properties of the nanocomposite caused its easy separation by using an external magnetic field from the reaction mixture without significant loss of its catalytic activity. In the experiment, the researchers used many compounds, for example, 2-Methoxybenzaldehyde(cas: 135-02-4Application In Synthesis of 2-Methoxybenzaldehyde)

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Application In Synthesis of 2-Methoxybenzaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Formula: C5H13NO2In 2022 ,《Practical and Highly Efficient Synthesis of Remdesivir from GS-441524》 appeared in ACS Omega. The author of the article were Hu, Tianwen; Zhu, Fuqiang; Xiang, Li; Shen, Jingshan; Xie, Yuanchao; Aisa, Haji A.. The article conveys some information:

A three-step sequence for preparing remdesivir, an important anti-SARS-CoV-2 drug, is described. Employing N,N-dimethylformamide di-Me acetal (DMF-DMA) as a protecting agent, this synthesis started from (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-furan-2-carbonitrile (GS-441524) and consisted of three reactions, including protection, phosphoramidation, and deprotection. The advantages of this approach are as follows: (1) the protecting group could be removed under a mild deprotection condition, which avoided the generation of the degraded impurity; (2) high stereoselectivity was achieved in the phosphorylated reaction; (3) this synthesis could be performed successively without purification of intermediates. Moreover, the overall yield of this approach on a gram scale could be up to 85% with an excellent purity of 99.4% analyzed by high-performance liquid chromatog. (HPLC). The results came from multiple reactions, including the reaction of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Formula: C5H13NO2)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Formula: C5H13NO2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

HPLC of Formula: 882-33-7In 2019 ,《RhCl3·3H2O-Catalyzed Ligand-Enabled Highly Regioselective Thiolation of Acrylic Acids》 was published in ACS Catalysis. The article was written by Liu, Can; Fang, Yi; Wang, Shun-Yi; Ji, Shun-Jun. The article contains the following contents:

The simple inorganic rhodium salt RhCl3·3H2O was used as a catalyst to achieve the thiolation of acrylic acids, with a series of (Z)-alkenyl sulfides being obtained exclusively. It is noteworthy that [Cp*RhCl2]2 was not as efficient as RhCl3·3H2O in this strategy. Furthermore, the products could be transformed conveniently into biol. and pharmacol. useful thioflavones. In the experimental materials used by the author, we found 1,2-Diphenyldisulfane(cas: 882-33-7HPLC of Formula: 882-33-7)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. HPLC of Formula: 882-33-7 The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Safety of Bis(4-methoxyphenyl)amineIn 2019 ,《Introduction of Fluorine Into spiro[fluorene-9,9′-xanthene]-Based Hole Transport Material to Obtain Sensitive-Dopant-Free, High Efficient and Stable Perovskite Solar Cells》 was published in Solar RRL. The article was written by Guo, Kunpeng; Wu, Min; Yang, Shaomin; Wang, Zongtao; Li, Jie; Liang, Xiaozhong; Zhang, Fang; Liu, Zhike; Wang, Zhongqiang. The article contains the following contents:

Despite the substantial development of efficient hole transporting materials (HTMs) for high-performance perovskite solar cells (PSCs), optimization of the HTMs to sensitive-dopant-free HTMs for high efficient PSCs with prominent stability have rarely been reported. Herein, a low-cost fluorinated spiro[fluorene-9,9′-xanthene] based HTM termed 2mF-X59 is designed and synthesized. In comparison with its reported nonfluorinated counterpart X59, 2mF-X59 shows lowered HOMO (HOMO) level, improved hole mobility, and hydrophobicity. Aided by 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane (F4TCNQ) to further lower the HOMO level of 2mF-X59 and improve its hole transfer, the optimized 2mF-X59 based PSCs show a maximum power conversion efficiency (PCE) of 18.13% without the use of any sensitive-dopants (e.g., lithium salt/4-tert-butylpyridine), which is comparable to the Spiro-OMeTAD based PSCs (18.22%) with sensitive dopants. More importantly, the sensitive-dopant-free 2mF-X59 based PSCs maintain 95% of their initial performance for more than 500 h under air exposure, showing much better long-term stability than control PSCs based on Spiro-OMeTAD with sensitive dopanst. This is the first case that a sensitive-dopant-free HTM is demonstrated in PSCs with a high PCE (>18%) and good stability by optimizing the literature HTM. This work could pave a new way to develop low-cost sensitive-dopant-free HTMs for highly efficient and stable PSCs for practical applications. In the experiment, the researchers used Bis(4-methoxyphenyl)amine(cas: 101-70-2Safety of Bis(4-methoxyphenyl)amine)

Bis(4-methoxyphenyl)amine(cas: 101-70-2) is a diphenylamine derivative used as a chemical additive for cured rubber.Bis(4-methoxyphenyl)amine is highly toxic and may potentially induce chromosome abberation.Safety of Bis(4-methoxyphenyl)amine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of C7H8O2In 2022 ,《Design, Synthesis and Bioactivity Evaluation of Coumarin-BMT Hybrids as New Acetylcholinesterase Inhibitors》 was published in Molecules. The article was written by Zeng, Fanxin; Lu, Tao; Wang, Jie; Nie, Xuliang; Xiong, Wanming; Yin, Zhongping; Peng, Dayong. The article contains the following contents:

The compound bridge methylene tacrine (BMT) was synthesized, which has the classical pharmacophore structure of Tacrine (THA). Based on the principle of active substructure splicing, BMT was used as a lead compound and synthesized coumarin-BMT hybrids I [n = 5, 6, 7; R1 = H, Me, MeO, F3CO, Br; R2 = H, MeO] by introducing coumarin to BMT. In this work, 21 novel hybrids of BMT and coumarin I were synthesized and evaluated for their inhibitory activity on AChE. All obtained compounds I presented preferable inhibition. Compound I [n = 6, R1 = Me, R2 = H] was the most active compound, with the value of Ki as 49.2 nM, which was higher than Galantamine (GAL) and lower than THA. The result of mol. docking showed that the highest binding free energy was -40.43 kcal/mol for compound I [n = 6, R1 = Me, R2 = H] which was an identical trend with the calculated Ki. The results came from multiple reactions, including the reaction of m-Methoxyphenol(cas: 150-19-6Synthetic Route of C7H8O2)

m-Methoxyphenol(cas: 150-19-6) may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.Synthetic Route of C7H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Self-Formed Protection Layer on a 3D Lithium Metal Anode for Ultrastable Lithium-Sulfur Batteries》 were Yan, Xinxiu; Zhang, Huan; Huang, Meiling; Qu, Meizhen; Wei, Zhikai. And the article was published in ChemSusChem in 2019. Application of 882-33-7 The author mentioned the following in the article:

Li metal anodes are a key component of high-energy-d. Li-S (Li-S) batteries. However, the issues associated with Li anodes remain unsolved owing to the immature Li anode construction and protection technol., which leads to internal short circuits, poor capacity retention, and low coulombic efficiency for high-S-loading Li-S batteries. Herein, a highly stable 3-dimensional Li C fiber composite (3-dimensional LiCF) anode for high-S-loading Li-S batteries was demonstrated, in which a self-formed hybrid solid-electrolyte protection layer was constructed on a Li metal surface through codeposition of thiophenolate ions and inorganic Li salts by using di-Ph disulfide as a co-additive in the electrolyte. The aromatic components from thiophenolate could improve the stability of the protection layer, and the 3-dimensional structure of the C fiber could effectively buffer the volume effect during Li cycling. A Li-S battery based on a 3-dimensional LiCF anode exhibited excellent cycling stability with an energy efficiency of 89.2% for 100 cycles in terms of a high energy d. of 22.3 mWh cm-2 (10 mAh cm-2 area capacity of Li cycling). This contribution demonstrates versatile and ingenious strategies for the construction of a 3-dimensional Li anode structure and protection layer, providing an effective solution for practical stable Li-S batteries. After reading the article, we found that the author used 1,2-Diphenyldisulfane(cas: 882-33-7Application of 882-33-7)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Application of 882-33-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《An APN-activated NIR photosensitizer for cancer photodynamic therapy and fluorescence imaging》 was published in Biomaterials in 2020. These research results belong to Zhou, Xiao; Li, Haidong; Shi, Chao; Xu, Feng; Zhang, Zhen; Yao, Qichao; Ma, He; Sun, Wen; Shao, Kun; Du, Jianjun; Long, Saran; Fan, Jiangli; Wang, Jingyun; Peng, Xiaojun. Application In Synthesis of 2-Hydroxy-4-methoxybenzaldehyde The article mentions the following:

Photodynamic therapy has been developed as a prospective cancer treatment in recent years. Nevertheless, conventional photosensitizers suffer from lacking recognition and specificity to tumors, which causing severe side effects to normal tissues, while the enzyme-activated photosensitizers are capable of solving these conundrums due to high selectivity towards tumors. APN (Aminopeptidase N, APN/CD13), a tumor marker, has become a crucial targeting substance owing to its highly expressed on the cell membrane surface in various tumors, which has become a key point in the research of anti-tumor drug and fluorescence probe. Based on it, herein an APN-activated near-IR (NIR) photosensitizer (APN-CyI) for tumor imaging and photodynamic therapy has been firstly developed and successfully applied in vitro and in vivo. Studies showed that APN-CyI could be activated by APN in tumor cells, hydrolyzed to fluorescent CyI-OH, which specifically located in mitochondria in cancer cells and exhibited a high singlet oxygen yield under NIR irradiation, and efficiently induced cancer cell apoptosis. Dramatically, the in vivo assays on Balb/c mice showed that APN-CyI could achieve NIR fluorescence imaging (λem = 717 nm) for endogenous APN in tumors and possessed an efficient tumor suppression effect under NIR irradiation The experimental process involved the reaction of 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Application In Synthesis of 2-Hydroxy-4-methoxybenzaldehyde)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Application In Synthesis of 2-Hydroxy-4-methoxybenzaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Nickel-Catalyzed Carbon-Sulfur Bond Formation through Couplings of Aryl Iodides and Aryl Ethanethioates》 was published in ChemistrySelect in 2020. These research results belong to Mao, Pu; Sui, Hong-Da; Yuan, Jin-Wei; Xiao, Yong-Mei; Yang, Liang-Ru; Mai, Wen-Peng. Electric Literature of C7H7IO The article mentions the following:

A nickel-catalyzed reductive coupling between aryl iodides 2-R-3-R1-4-R2-C6H2I (R = H, OMe, Cl; R1 = H, Me; R2 = H, F, CF3, Ph, etc.) and aryl ethanethioates 3-R3-4-R4-C6H3XC(O)R5 (X = S, O; R3 = H, F; R4 = H, Me, Cl, OMe, OCF3; R5 = Me, Ph, 2,2,2-trifluoroethyl, 3,3,3-trifluoropropyl) has been developed to afford diaryl sulfides 2-R-3-R1-4-R2-C6H2SC6H3-3-R3-4-R4. This method provides a novel and practical route to aryl thioetherification and can be effectively applied to electronically diverse aryl iodides without expensive metals such as palladium and ruthenium. In the experiment, the researchers used 1-Iodo-2-methoxybenzene(cas: 529-28-2Electric Literature of C7H7IO)

1-Iodo-2-methoxybenzene(cas: 529-28-2) participates in palladium catalyzed enantioselective Heck arylation of 2,3-dihydrofuran in the presence of chiral ionic liquids containing L-prolinate and L-lactate anions and non-chiral quaternary ammonium cations.Electric Literature of C7H7IO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Nickel-catalyzed removal of alkene protecting group of phenols, alcohols via chain walking process》 was written by Meng, Chenkai; Niu, Haolin; Ning, Juehan; Wu, Wengang; Yi, Jun. Recommanded Product: m-Methoxyphenol And the article was included in Molecules in 2020. The article conveys some information:

An efficient nickel-catalyzed removal of alkene protection group under mild condition with high functional group tolerance through chain walking process has been established. Not only phenolic ethers, but also alc. ethers can be tolerated with the retention of stereocenter adjacent to hydroxyl group. The new reaction brings the homoallyl group into a start of new type of protecting group.m-Methoxyphenol(cas: 150-19-6Recommanded Product: m-Methoxyphenol) was used in this study.

m-Methoxyphenol(cas: 150-19-6) may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.Recommanded Product: m-Methoxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Suo, Xian; Yang, Zhenzhen; Fu, Yuqing; Do-Thanh, Chi-Linh; Chen, Hao; Luo, Huimin; Jiang, De-en; Mahurin, Shannon M.; Xing, Huabin; Dai, Sheng published their research in ChemSusChem in 2021. The article was titled 《CO2 Chemisorption Behavior of Coordination-Derived Phenolate Sorbents》.HPLC of Formula: 33100-27-5 The article contains the following contents:

CO2 chemisorption via C-O bond formation is an efficient methodol. in carbon capture especially using phenolate-based ionic liquids (ILs) as the sorbents to afford carbonate products. However, most of the current IL systems involve alkylphosphonium cations, leading to side reactions via the ylide intermediate pathway. It is important to figure out the CO2 chemisorption behavior of phenolate-derived sorbents using inactive and easily accessible cation counterparts without active protons. Herein, phenolate-based systems were constructed via coordination between alkali metal cations with crown ethers to avoid the participation of active protons in CO2 chemisorption. Reaction pathway study revealed that CO2 uptake could be achieved by O-C bond formation to afford carbonate. CO2 uptake capacity and reaction enthalpy were significantly influenced by the coordination effect, alkali metal types, and alkyl groups on the benzene ring. In the part of experimental materials, we found many familiar compounds, such as 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5HPLC of Formula: 33100-27-5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. HPLC of Formula: 33100-27-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem