Category: 74654-07-2

Reference of 74654-07-2, These common heterocyclic compound, 74654-07-2, name is 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-(3,4-Dichlorophenyl)-N-{(l S)-2-((3S)-3-hydroxypyrrolidin-l -yl)-l – phenylethyl}-N-methylacetamide (3) (0.030 g, 0.074 mmol) and 4-nitrophenyl carbonochloride (0.017 g, 0.081 mmol) were dissolved in 3 mL of dichloromethane. N,N- diisopropylethylamine (0.018 g, 0.15 mmol) was added under stirring. The reaction mixture was stirred at room temperature for two hours. 2-(2-(2-methoxyethoxy)ethoxy)ethanamine (0.033 g, 0.20 mmol) was added. The reaction mixture was stirred at room temperature for 6 hours. 100 mL of dichloromethane was added into the reaction mixture. The resultant solution was washed with saturated sodium chloride (60 mL chi 3) and was dried over sodium sulfate. Evaporation of the solvent and purification of the residue by flash chromatography yielded (35)-l -[(21S)-2-{[(3,4-Dichlorophenyl)acetyl](methyl)amino}-2- phenylethyl]pyrrolidin-3-yl {2-[2-(2-methoxyethoxy)ethoxy]ethyl} carbamate (0.023 g, 58% yield). NMR (500 MHz, CDC13): delta 7.45-7.26 (m, 7H), 7.16 (m, 1 H), 6.10 (m, 0.85H), 5.20 (m, 2H), 5.05 (m, 0.15H), 3.85-3.62 (m, 10H), 3.57 (m, 4H), 3.38 (s, 3H), 3.15 (t, 1 H), 2.98 (m, 2H), 2.75 (m, 4H), 2.40 (m, 1H), 2.20 (m, 1 H), 1.82 (m, 2H); MS (EI) for C29H39C12N306: 596 (MH+).

Statistics shows that 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine is playing an increasingly important role. we look forward to future research findings about 74654-07-2.

Reference:
Patent; NEKTAR THERAPEUTICS; ANAND, Neel, K.; DUARTE, Franco, J.; ZHANG, Wen; REN, Zhongxu; WO2014/210436; (2014); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 74654-07-2, name is 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 74654-07-2, Quality Control of 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine

Example 56A tert-Butyl [(trans-4-{[(2S)-3-[5′-({2-[2-(2-methoxyethoxy)ethoxy]ethyl}carbamoyl)-2′-methylbiphenyl-3-yl]-1-oxo-1-{[4-(1H-tetrazol-5-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate 3′-[(2S)-2-{[(trans-4-{[(tert-Butoxycarbonyl)amino]methyl}cyclohexyl)carbonyl]amino}-3-oxo-3-{[4-(1H-tetrazol-5-yl)phenyl]amino}propyl]-6-methylbiphenyl-3-carboxylic acid (100 mg, 0.15 mmol) and 2-[2-(2-methoxyethoxy)ethoxy]ethanamine (29 mg, 0.17 mmol) were dissolved in tetrahydrofuran (4 ml), N-[(dimethylamino)(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy)methylidene]-N-methylmethanaminium hexafluorophosphate (67 mg, 0.17 mmol) and N,N-diisopropylethylamine (23 mg, 0.17 mmol) were added and the mixture was stirred at RT overnight. Subsequently, the mixture was concentrated and the residue was purified chromatographically by HPLC (Method 10). This gave 45 mg (37% of theory) of the title compound. LC-MS (Method 4): Rt=1.20 min; MS (ESIpos): m/z=827.6 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Bayer Pharma Aktiengesellschaft; ROeHN, Ulrike; ELLERMANN, Manuel; STRASSBURGER, Julia; WENDT, Astrid; ROeHRIG, Susanne; WEBSTER, Robert Alan; SCHMIDT, Martina Victoria; TERSTEEGEN, Adrian; BEYER, Kristin; SCHAeFER, Martina; BUCHMUeLLER, Anja; GERDES, Christoph; SPERZEL, Michael; SANDMANN, Steffen; HEITMEIER, Stefan; HILLISCH, Alexander; ACKERSTAFF, Jens; TERJUNG, Carsten; (163 pag.)US2016/244437; (2016); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 74654-07-2, name is 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 74654-07-2, Recommanded Product: 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine

To a 20 L flask under nitrogen was added 2-(2-(2-methoxyethoxy)ethoxy)ethanamine (890 g, 5.45 mol) and DCM (3.5 L). This was followed by the addition of 8% aq NaHCO3 (9 L). The acid chloride (1373 g active, 4.89 mol) was then added to the mixture while maintaining the temperature below 25 C. [EXOTHERM and GAS EVOLUTION]. The mixture was stirred for 30 mins, after which LC indicated complete reaction. The organics were separated and washed with 1 M HCl (4.5 L) and 8% aq NaHCO3 (4.5 L), before being dried, filtered and concentrated in vacuo to give a total of 1956 g of the sub-title compound (95% yield). Analysis by 1H NMR indicated a product purity of >95%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Topivert Pharma Limited; Respivert Limited; BAKER, Thomas Matthew; FYFE, Matthew Colin Thor; HARBOTTLE, Gareth William; HASIMBEGOVIC, Vedran; MEGHANI, Premji; RIGBY, Aaron; SAMBROOK-SMITH, Colin; THOM, Stephen Malcolm; US2014/296208; (2014); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 74654-07-2, The chemical industry reduces the impact on the environment during synthesis 74654-07-2, name is 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, I believe this compound will play a more active role in future production and life.

Weigh A4 (0.841 g, 1 mmol) in 15 ml DMF in a 25 ml one-neck flask and add NMM (N-methylmorpholine) (112 muL, 1.0 mmol) and HATU Benzotriazole) -N, N, N ‘, N’-tetramethyluronium hexafluorophosphate) (0.57 g, 1.5 mmol) was activated for 30 min.Add PEG163 (0.163g, 1mmol) with stirring for 1h, then warmed to room temperature for reaction for 10h. The reaction was stopped and dichloromethane was added for extraction. The mixture was washed twice with water and twice with saturated NaCl solution. The organic phase was distilled under reduced pressure to give 0.91g of light yellow solid. Column chromatography white solid 0.651g, 65.08% yield.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shanghai Jiao Tong University; Shen Yumei; Gong Bing; Tan Lianjiang; Shao Zhifeng; Yang Qinglai; Li Xiaowei; Jiang Yu; Zhang Zhen; (42 pag.)CN104693258; (2017); B;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 74654-07-2, name is 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, A new synthetic method of this compound is introduced below., Quality Control of 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine

A solution of cyanoacetic acid (621 mg, 7.3 mmol) in anhydrous DCM (15 mL) was cooled to 0C. Separately, a solution of hydroxybenzothiazole (HOBt) (1.48 g, 10.97 mmol) and 2-(2-(2-methoxyethoxy)ethoxy)ethanamine (A2, 1.79 g, 10.97 mmol) was prepared in DCM (10 mL); this solution was then added dropwise to the cooled solution of cyanoacetic acid. The resulting solution was allowed to stir for 10 minutes at 0C, upon which l-ethyl-3-(3- dimethylaminopropyl)carbodiimide (EDC) (2.1 g, 10.97 mmol) was added in one portion and the reaction stirred under argon at 0C for 12 hours. The reaction was then concentrated and purified by silica gel chromatography (0-2% MeOH/DCM) to obtain 2-cyano-N-(2-(2-(2- methoxyethoxy)ethoxy)ethyl)acetamide A3 as a yellow oil in 83% yield.

The synthetic route of 74654-07-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AMYDIS DIAGNOSTICS; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; YANG, Jerry; THEODORAKIS, Emmanuel, A.; SARRAF, Stella; WO2015/143185; (2015); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 74654-07-2, name is 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 74654-07-2, Formula: C7H17NO3

Example 54A tert-Butyl [(trans-4-{[(2S)-3-[3′-({2-[2-(2-methoxyethoxy)ethoxy]ethyl}carbamoyl)-6-methylbiphenyl-3-yl]-1-oxo-1-{[4-(1H-tetrazol-5-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate 5′-[(2S)-2-{[(trans-4-{[(tert-Butoxycarbonyl)amino]methyl}cyclohexyl)carbonyl]amino}-3-oxo-3-{[4-(1H-tetrazol-5-yl)phenyl]amino}propyl]-2′-methylbiphenyl-3-carboxylic acid (90 mg, 0.13 mmol) and 2-[2-(2-methoxyethoxy)ethoxy]ethanamine (26 mg, 0.16 mmol) were dissolved in tetrahydrofuran (4 ml), N-[(dimethylamino)(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy)methylidene]-N-methylmethanaminium hexafluorophosphate (60 mg, 0.16 mmol) and N,N-diisopropylethylamine (20 mg, 0.16 mmol) were added and the mixture was stirred at RT overnight. Subsequently, the mixture was concentrated and the residue was purified chromatographically by HPLC (Method 10). This gave 42 mg (38% of theory) of the title compound. LC-MS (Method 4): Rt=1.20 min; MS (ESIpos): m/z=827.6 [M+H]+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Bayer Pharma Aktiengesellschaft; ROeHN, Ulrike; ELLERMANN, Manuel; STRASSBURGER, Julia; WENDT, Astrid; ROeHRIG, Susanne; WEBSTER, Robert Alan; SCHMIDT, Martina Victoria; TERSTEEGEN, Adrian; BEYER, Kristin; SCHAeFER, Martina; BUCHMUeLLER, Anja; GERDES, Christoph; SPERZEL, Michael; SANDMANN, Steffen; HEITMEIER, Stefan; HILLISCH, Alexander; ACKERSTAFF, Jens; TERJUNG, Carsten; (163 pag.)US2016/244437; (2016); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 74654-07-2, name is 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 74654-07-2, HPLC of Formula: C7H17NO3

A solution of methoxy-oligo(ethylene glycol) amine (2c-4c) (8.2 mmol, 1.0 eq.) and DMAP (2.00 g,16.4 mmol, 2.0 eq.) in acetonitrile (15 mL) was added dropwise to a solution of bis(4-nitrophenyl)carbonate (2.74 g, 9.0 mmol, 1.1 eq.) in acetonitrile (15 mL) and the resulting solution was stirred at50 C for 3 h. The reaction mixture was then diluted in DCM (150 mL) and washed with 0.5 N HCl(100 mL). The aqueous layer was washed with DCM (5 ¡Á 100 mL) and all the organic fractions werecollected, dried over MgSO4 and filtered. The solvent was evaporated under reduced pressure and theresidue was purified by flash chromatography. 4-Nitrophenyl (2-(2-(2-methoxyethoxy)ethoxy)ethyl)carbamate (2c). Purified by flash chromatographyusing DCM/Acetone = 9:1 as eluent. 87% yield as a pale yellow oil. 1H-NMR (250 MHz, CDCl3) delta(ppm): 3.31 (s, 3H, -O-CH3), 3.37-3.43 (m, 2H, -O-CH2-CH2-NH-), 3.49-3.63 (m, 10H, 2 ¡Á-O-CH2-CH2-O- + -O-CH2-CH2-NH-), 6.06 (t, 1H, -NH-, 3JH-H = 5 Hz), 7.25 (d, 2H, Ar-H,3JH-H = 9.25 Hz), 8.15 (d, 2H, Ar-H, 3JH-H = 9.25 Hz); 13C-NMR (62.9 MHz, CDCl3) delta (ppm): 155.9,153.1, 144.3, 124.8, 121.8, 71.6, 70.2, 70.2, 69.9, 69.3, 58.7, 40.8; ESI-MS (ion trap): m/z 329 [M + H]+.HRMS (ESI+): m/z 329.1357 [M + H]+, calcd for C14H21N2O7: 329.1349.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Mattarei, Andrea; Azzolini, Michele; Zoratti, Mario; Biasutto, Lucia; Paradisi, Cristina; Molecules; vol. 20; 9; (2015); p. 16085 – 16102;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 74654-07-2, The chemical industry reduces the impact on the environment during synthesis 74654-07-2, name is 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, I believe this compound will play a more active role in future production and life.

HATU (500 mg, 1.315 mmol) was added to a stirred solution of 3-((4-((tert-butoxycarbonyl)amino)naphthalen-1-yl)oxy)pyridin-2-yl)amino)-5-ethynylbenzoic acid (see Example 52(iii) above; 500 mg, 1.009 mmol), 2-(2-(2-methoxyethoxy)ethoxy)-ethanamine (277 mg, 1.695 mmol) and triethylamine (250 muL, 1.796 mmol) in N,N-dimethylformamide (10 mL). The mixture was stirred at rt for 18 h. The mixture was diluted with EtOAc (50 mL) and washed with water (50 mL), 20% brine (3*50 mL) and saturated brine (50 mL). The organic phase was dried (MgSO4), filtered and concentrated under reduced pressure. The crude product was purified by chromatography on the Companion (40 g column, EtOAc) to afford the sub-title compound (580 mg) as a tan foam. LCMS m/z 641 (M+H)+ (ES+); 639 (M-H)- (ES-)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Topivert Pharma Limited; Respivert Limited; BAKER, Thomas Matthew; FYFE, Matthew Colin Thor; HARBOTTLE, Gareth William; HASIMBEGOVIC, Vedran; MEGHANI, Premji; RIGBY, Aaron; SAMBROOK-SMITH, Colin; THOM, Stephen Malcolm; US2014/296208; (2014); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 74654-07-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 74654-07-2, name is 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, This compound has unique chemical properties. The synthetic route is as follows.

Benzhydryl 2-chloroethyl ether (2 mmol) and mPEGn-NH2 (3 mmol) were dissolved in 10 ml of acetonitrile, and then sodium hydroxide (2 mmol) in water (1 mL) was added to the solution. The mixture was stirred at 100 C for 16 hours. Dichloromethane (200 ml) was added to the reaction mixture, and the resulting solution was washed with water (200 mL x 3). The organic phase was dried and solvent was removed under reduced pressure. The crude product was purified by column chromatography (SiO2: DCM/CH3OH, 20:1) or alternatively using flash chromatography on silica gel using CAN/H2O (40M C-18RP column, Biotage, Inc., Charlottesville, VA). The desired product of mPEGn-NH- diphenhydramine obtained in -70% yield and mPEGn-N-(diphenhydramine)2 was also obtained in 15% yield.

The chemical industry reduces the impact on the environment during synthesis 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine. I believe this compound will play a more active role in future production and life.

Reference:
Patent; NEKTAR THERAPEUTICS AL, CORPORATION; WO2008/112257; (2008); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 74654-07-2, name is 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 74654-07-2, COA of Formula: C7H17NO3

Synthesis of compound 2 is shown in Figure 3. The synthesis began with converting chloroacetonitrile (13) to the sulfonic acid and then to the sulfonyl chloride (14) in 13% yield over two steps. Sulfonyl chloride (14) was found to be relatively unstable and therefore was quickly reacted with amine-TEG (7) to give sulfonamide-TEG (15) in 86% yield. Sulfonamide-TEG (15) was then condensed with aldehyde (12) to give compound 2 in 73% yield. [00311] Characterization data:

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; AMYDIS DIAGNOSTICS; SARRAF, Stella; (168 pag.)WO2016/40891; (2016); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem