Reference of 74654-07-2, These common heterocyclic compound, 74654-07-2, name is 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2-(3,4-Dichlorophenyl)-N-{(l S)-2-((3S)-3-hydroxypyrrolidin-l -yl)-l – phenylethyl}-N-methylacetamide (3) (0.030 g, 0.074 mmol) and 4-nitrophenyl carbonochloride (0.017 g, 0.081 mmol) were dissolved in 3 mL of dichloromethane. N,N- diisopropylethylamine (0.018 g, 0.15 mmol) was added under stirring. The reaction mixture was stirred at room temperature for two hours. 2-(2-(2-methoxyethoxy)ethoxy)ethanamine (0.033 g, 0.20 mmol) was added. The reaction mixture was stirred at room temperature for 6 hours. 100 mL of dichloromethane was added into the reaction mixture. The resultant solution was washed with saturated sodium chloride (60 mL chi 3) and was dried over sodium sulfate. Evaporation of the solvent and purification of the residue by flash chromatography yielded (35)-l -[(21S)-2-{[(3,4-Dichlorophenyl)acetyl](methyl)amino}-2- phenylethyl]pyrrolidin-3-yl {2-[2-(2-methoxyethoxy)ethoxy]ethyl} carbamate (0.023 g, 58% yield). NMR (500 MHz, CDC13): delta 7.45-7.26 (m, 7H), 7.16 (m, 1 H), 6.10 (m, 0.85H), 5.20 (m, 2H), 5.05 (m, 0.15H), 3.85-3.62 (m, 10H), 3.57 (m, 4H), 3.38 (s, 3H), 3.15 (t, 1 H), 2.98 (m, 2H), 2.75 (m, 4H), 2.40 (m, 1H), 2.20 (m, 1 H), 1.82 (m, 2H); MS (EI) for C29H39C12N306: 596 (MH+).
Statistics shows that 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine is playing an increasingly important role. we look forward to future research findings about 74654-07-2.
Reference:
Patent; NEKTAR THERAPEUTICS; ANAND, Neel, K.; DUARTE, Franco, J.; ZHANG, Wen; REN, Zhongxu; WO2014/210436; (2014); A2;,
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