Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 74654-07-2, name is 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, A new synthetic method of this compound is introduced below., Quality Control of 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine
A solution of cyanoacetic acid (621 mg, 7.3 mmol) in anhydrous DCM (15 mL) was cooled to 0C. Separately, a solution of hydroxybenzothiazole (HOBt) (1.48 g, 10.97 mmol) and 2-(2-(2-methoxyethoxy)ethoxy)ethanamine (A2, 1.79 g, 10.97 mmol) was prepared in DCM (10 mL); this solution was then added dropwise to the cooled solution of cyanoacetic acid. The resulting solution was allowed to stir for 10 minutes at 0C, upon which l-ethyl-3-(3- dimethylaminopropyl)carbodiimide (EDC) (2.1 g, 10.97 mmol) was added in one portion and the reaction stirred under argon at 0C for 12 hours. The reaction was then concentrated and purified by silica gel chromatography (0-2% MeOH/DCM) to obtain 2-cyano-N-(2-(2-(2- methoxyethoxy)ethoxy)ethyl)acetamide A3 as a yellow oil in 83% yield.
The synthetic route of 74654-07-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AMYDIS DIAGNOSTICS; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; YANG, Jerry; THEODORAKIS, Emmanuel, A.; SARRAF, Stella; WO2015/143185; (2015); A1;,
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