Application of 74654-07-2, The chemical industry reduces the impact on the environment during synthesis 74654-07-2, name is 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, I believe this compound will play a more active role in future production and life.
Weigh A4 (0.841 g, 1 mmol) in 15 ml DMF in a 25 ml one-neck flask and add NMM (N-methylmorpholine) (112 muL, 1.0 mmol) and HATU Benzotriazole) -N, N, N ‘, N’-tetramethyluronium hexafluorophosphate) (0.57 g, 1.5 mmol) was activated for 30 min.Add PEG163 (0.163g, 1mmol) with stirring for 1h, then warmed to room temperature for reaction for 10h. The reaction was stopped and dichloromethane was added for extraction. The mixture was washed twice with water and twice with saturated NaCl solution. The organic phase was distilled under reduced pressure to give 0.91g of light yellow solid. Column chromatography white solid 0.651g, 65.08% yield.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Shanghai Jiao Tong University; Shen Yumei; Gong Bing; Tan Lianjiang; Shao Zhifeng; Yang Qinglai; Li Xiaowei; Jiang Yu; Zhang Zhen; (42 pag.)CN104693258; (2017); B;,
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