Ethers-buliding-blocks

Application of 60789-54-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 60789-54-0 as follows.

Norspermidine (20) was reacted with benzyl 4-bromobutyl ether (21,1. 2 equiv) over a day at room temperature in the presence of 1.4 equivalents of cesium hydroxide monohydrate and 4 A molecular sieves in DMF to give 22. The amino groups were protected using di (t-butyl) dicarbonate in aqueous tetrahydrofuran (THF) to give 23. Calcium in ammonia and THF efficiently generated alcohol 24.

According to the analysis of related databases, 60789-54-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.; WO2005/23310; (2005); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 107622-80-0,Some common heterocyclic compound, 107622-80-0, name is (4-Phenoxyphenyl)methanamine, molecular formula is C13H13NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The appropriate pyrazole (1.0 equiv) was treated with phosgene (10equiv, 20% in toluene) at 0 C. The reaction mixture was stirred at roomtemperature for 1 h. The solvent was removed under reduced pressureand the crude carbamoyl chloride was dissolved in anhydrous CH2Cl2(0.5 M). The appropriate amine (1.0 equiv) or alcohol (1 equiv) andEt3N (1.2 equiv) were dissolved in CH2Cl2 (0.5 M) and cooled to 0 C.The crude carbamoyl chloride was added dropwise and the reactionmixture was stirred at room temperature for 16 h. The mixture wasdiluted with EtOAc, washed with saturated aqueous NaCl, and driedover Na2SO4. Evaporation under reduced pressure yielded the crudecoupling product that was purified by flash chromatography (SiO2).

The synthetic route of 107622-80-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Otrubova, Katerina; Chatterjee, Shreyosree; Ghimire, Srijana; Cravatt, Benjamin F.; Boger, Dale L.; Bioorganic and Medicinal Chemistry; vol. 27; 8; (2019); p. 1693 – 1703;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 36805-97-7, These common heterocyclic compound, 36805-97-7, name is 1,1-Di-tert-butoxy-N,N-dimethylmethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

a) 2,6-Dichloro-isonicotinic acid (11.2 g, 57.1 mmol) is suspended in toluene (150 mL) at 80 C. and then treated with N,N-dimethylformamide di-tert.-butyl acetal (50 mL, 209 mmol). The dark mixture is stirred at 80 C. for 12 h, then at rt for 16 h. The dark solution is diluted with diethyl ether (400 mL), washed with sat. aq. NaHCO3 solution (3*100 mL), dried over Na2SO4, filtered and concentrated. The crude product is purified by MPLC on silica gel eluting with a gradient of EA in heptane to give 2,6-dichloro-isonicotinic acid tert.-butyl ester (14.2 g) as a brownish oil which slowly solidifies; LC-MS: tR=1.05 min; 1H NMR (D6-DMSO): delta 1.56 (s, 9H), 7.85 (s, 2H).

The synthetic route of 36805-97-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bolli, Martin; Lescop, Cyrille; Mathys, Boris; Mueller, Claus; Nayler, Oliver; Steiner, Beat; Velker, Jorg; US2011/212998; (2011); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 36805-97-7, name is 1,1-Di-tert-butoxy-N,N-dimethylmethanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 1,1-Di-tert-butoxy-N,N-dimethylmethanamine

Following the general procedure of Tagat (Tagat, J.R.; McCombie, S.W.; Nazareno, D.V.;Boyle, CD.; Kozlowski, J.A.; Chackalamannil, S.; Josien, H.; Wang, Y.; Zhou, G. J. Org. Chem. 2002, 67, 1171-77), a suspension of the bromo acid x (3.0 g, 12.0 mmol) in toluene (18 mL) was heated at 80 0C. To this reaction mixture was added dropwise N,N- dimethylformamide i-tert-butyl acetal (10.0 mL, 42 mmol), and the resulting mixture was heated for an additional 30 min. It was cooled to it, washed with water, saturated aqueous NaHCO3, brine, dried (Na2SO4), filtered, and concentrated in vacuo to afford 2.87 g (78%) of f-butyl ester k_l as a yellow oil, which was carried on without further purification.

The synthetic route of 36805-97-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GENENTECH, INC.; WO2006/69063; (2006); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 107622-80-0, name is (4-Phenoxyphenyl)methanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 107622-80-0, Computed Properties of C13H13NO

A mixture of ethyl 5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazole-2-carboxylate (0.3003 g, 0.990 mmol) and 4-phenoxybenzylamine (0.5922 g, 2.97 mmol) in ethanol (10 mL) was stirred at 80 C. under nitrogen for 2 d. The mixture was partitioned between dilute aqueous HCl (50 mL) and ethyl acetate (75 mL). The aqueous layer was extracted further with ethyl acetate (50 mL) and the combined extracts were washed with brine (30 mL), dried (MgSO4) and evaporated. The residue was purified by flash chromatography (silica gel, 2% MeOH/CH2Cl2) to give 0.4235 g (94%) of the title compound as a white solid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Institute for OneWorld Health; US2010/267725; (2010); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 104-92-7, The chemical industry reduces the impact on the environment during synthesis 104-92-7, name is 1-Bromo-4-methoxybenzene, I believe this compound will play a more active role in future production and life.

General procedure: To a stirred solution of 1.0 mmol of aryl halide in 4 mL of DMF,1.0 mmol of terminal alkyne, 1.5 mmol of piperidine and 0.2 mol%of Pd/Fe3O4NPs were added and the mixture was heated on anoil bath at 110C for 24 h under inert atmosphere (N2). After com-pletion of the reaction (as monitored by TLC), the reaction mixturewas cooled to room temperature and the catalyst was separatedusing a magnetic separator. The solvent was evaporated at reducedpressure, and the residue was subjected to gel permeation chro-matography to afford pure products. All the products are knowncompounds and the spectral data and melting points were identicalto those reported in the literature

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-methoxybenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Nasrollahzadeh, Mahmoud; Mohammad Sajadi; Rostami-Vartooni, Akbar; Khalaj, Mehdi; Journal of Molecular Catalysis A: Chemical; vol. 396; (2015); p. 31 – 39;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 1516-96-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1516-96-7, name is 5-Bromo-1,3-di-tert-butyl-2-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.

Under nitrogen protection, to a 250 mL dry 3-necked round bottom flask equipped with a magnetic stirrer and thermometer was added:THE was added dropwise to the solution of the residue prepared above under nitrogen at 0C. After stirring another 1.5h at room temperature, the mixture was quenched withwater at 0C and extracted three times withdichloromethane. The combined organic layers were dried over Na2504 and concentrated in vacuo. The residue was purified by flash chromatography on silica gel, eluting with petroleum ether/ethyl acetate = 75:25, to give product as a white solid (1.94 g, 81% yield).1.0 g tetraethyl (((2R)-propane-1,2-diylbis(oxy))bis(3,1-phenylene))bis(phosphonate) (2.0 mmol, 1.0 equiv.) in3.0 mL thionyl chloride (40.0 mmol, 20.0 equiv.) under nitrogen was added30.0 iL dimethylformamide (0.4 mmol, 0.2 equiv). The mixture was stirred under reflux for 18 h, during which time15.0 iL dimethylformamide (all together 8.0 mmol, 0.3 equiv.) was added after 12h. After the solvent was evaporated, the residue was dissolve in5.0 mL THE and concentrated in vacuo (once). The residue was used for the next step without further purification.To a phenyl magnesium bromide solution prepared from a suspension of0.53g magnesium turning (22.0 mmol, 11.0 equiv.) and6.0 g 5-bromo-1,3-di-tert-butyl-2-methoxybenzene (20.0 mmol, 10.0 equiv.) in20.0 mL10.0 mL50 mL

The chemical industry reduces the impact on the environment during synthesis 5-Bromo-1,3-di-tert-butyl-2-methoxybenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; DSM IP ASSETS B.V.; BONRATH, Werner; FENG, Zheng-Chuan; MEDLOCK, Jonathan, Alan; PENG, Kun; ZHU, Zhibin; (28 pag.)WO2018/189107; (2018); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 35822-58-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35822-58-3, name is 2-Bromobenzaldehyde diethyl acetal, This compound has unique chemical properties. The synthetic route is as follows.

To a cooled solution of 5 g (1 9.3 mmol) of 1 -bromo-2-(diethoxymethyl)benzene in 40 mL of diethylether, are slowly added 12 mL (1 9.3 mmol) of a 1 .6 M solution of butyllithium. The reaction mixture is stirred at ambient temperature for 1 hr. After slow addition of 4.28 g (25 mmol) of chloro(dimethyl)phenylsilane, the reaction mixture is further stirred for 2 hrs at ambient temperature, then poured over a mixture of ice and 40 mL of 1 N HCI and stirred overnight. The watery layer is extracted with 2 x 50 mL of ethyl acetate. The organic layer is washed twice by a concentrated aqueous solution of NaCI and dried over magnesium sulfate to yield after concentration, 5.45 g of a yellow oil. Column chromatography on silica gel (gradient n-heptane/ethyl acetate) yields 4.65 g (100% yield) of 2-[dimethyl(phenyl)silyl]benzaldehyde as a colorless oil. (M+H = 241 ).

The chemical industry reduces the impact on the environment during synthesis 2-Bromobenzaldehyde diethyl acetal. I believe this compound will play a more active role in future production and life.

Reference:
Patent; BAYER CROPSCIENCE AG; CRISTAU, Pierre; DESBORDES, Philippe; ES-SAYED, Mazen; GROSJEAN-COURNOYER, Marie-Claire; LACHAISE, Helene; RINOLFI, Philippe; SCHMIDT, Jan-Peter; TSUCHYIA, Tomoki; VORS, Jean-Pierre; WO2013/156560; (2013); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 332-48-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 332-48-9, name is 1-(2-Bromoethoxy)-4-fluorobenzene, This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 2 Compound No. 2 2-[1-[2-(4-Fluorophenoxy)ethyl]piperidin-4-ylamino]pyrimidine-4-carboxamide, hydrochloride. 2.1 8-[2-(4-Fluorophenoxy)ethyl]-1,4-dioxa-8-azaspiro-[4.5]decane. 21.91 g (0.1 mol) of 2-(4-fluorophenoxy)ethyl bromide, 14.32 g (0.1 mol) of 1,4-dioxa-8-azaspiro[4.5]decane and 20.73 g (0.15 mol) of potassium carbonate are introduced into 250 ml of 2-butanone and the mixture is heated at boiling for 7 hours. The mixture is cooled to room temperature, filtered, the insoluble material washed with 200 ml of ether and the solvents evaporated under reduced pressure. 29 g of a yellow oil are obtained which is used as it is in the following stage.

The chemical industry reduces the impact on the environment during synthesis 1-(2-Bromoethoxy)-4-fluorobenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Synthelabo; US5246939; (1993); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 1758-46-9,Some common heterocyclic compound, 1758-46-9, name is 2-Phenoxyethylamine, molecular formula is C8H11NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution OF 5- (3APOS;-CARBOXY-4-METHOXY-1, 1APOS;-BIPHEN-3-YL)-1, 2,5-thiadiazolidin-3-one 1, 1-dioxide (Example 43) (0.05 g, 0.14 mmol, 1 eq. ) and DIPEA (24 L, 0.14 mmol, 1 eq. ) in DCM (2mL) added HOBt (19 mg, 0.14 mmol, 1 eq. ), 2-phenoxyethylamine (18 RL, 0.14 mmol, 1 eq. ) and EDCI (31 mg, 0.17 mmol, 1.2 eq. ). The reaction was allowed to stir at ambient temperature overnight and then the solvent was removed under reduced pressure. The residue was taken up in acetonitrile: water (1: 1,3 mL) and purified by reverse phase preparative HPLC to afford the title compound as a colourless solid (0.04 g, 60percent yields

The synthetic route of 1758-46-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2004/41799; (2004); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem