Synthetic Route of 35822-58-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35822-58-3, name is 2-Bromobenzaldehyde diethyl acetal, This compound has unique chemical properties. The synthetic route is as follows.
To a cooled solution of 5 g (1 9.3 mmol) of 1 -bromo-2-(diethoxymethyl)benzene in 40 mL of diethylether, are slowly added 12 mL (1 9.3 mmol) of a 1 .6 M solution of butyllithium. The reaction mixture is stirred at ambient temperature for 1 hr. After slow addition of 4.28 g (25 mmol) of chloro(dimethyl)phenylsilane, the reaction mixture is further stirred for 2 hrs at ambient temperature, then poured over a mixture of ice and 40 mL of 1 N HCI and stirred overnight. The watery layer is extracted with 2 x 50 mL of ethyl acetate. The organic layer is washed twice by a concentrated aqueous solution of NaCI and dried over magnesium sulfate to yield after concentration, 5.45 g of a yellow oil. Column chromatography on silica gel (gradient n-heptane/ethyl acetate) yields 4.65 g (100% yield) of 2-[dimethyl(phenyl)silyl]benzaldehyde as a colorless oil. (M+H = 241 ).
The chemical industry reduces the impact on the environment during synthesis 2-Bromobenzaldehyde diethyl acetal. I believe this compound will play a more active role in future production and life.
Reference:
Patent; BAYER CROPSCIENCE AG; CRISTAU, Pierre; DESBORDES, Philippe; ES-SAYED, Mazen; GROSJEAN-COURNOYER, Marie-Claire; LACHAISE, Helene; RINOLFI, Philippe; SCHMIDT, Jan-Peter; TSUCHYIA, Tomoki; VORS, Jean-Pierre; WO2013/156560; (2013); A1;,
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