Related Products of 332-48-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 332-48-9, name is 1-(2-Bromoethoxy)-4-fluorobenzene, This compound has unique chemical properties. The synthetic route is as follows.
EXAMPLE 2 Compound No. 2 2-[1-[2-(4-Fluorophenoxy)ethyl]piperidin-4-ylamino]pyrimidine-4-carboxamide, hydrochloride. 2.1 8-[2-(4-Fluorophenoxy)ethyl]-1,4-dioxa-8-azaspiro-[4.5]decane. 21.91 g (0.1 mol) of 2-(4-fluorophenoxy)ethyl bromide, 14.32 g (0.1 mol) of 1,4-dioxa-8-azaspiro[4.5]decane and 20.73 g (0.15 mol) of potassium carbonate are introduced into 250 ml of 2-butanone and the mixture is heated at boiling for 7 hours. The mixture is cooled to room temperature, filtered, the insoluble material washed with 200 ml of ether and the solvents evaporated under reduced pressure. 29 g of a yellow oil are obtained which is used as it is in the following stage.
The chemical industry reduces the impact on the environment during synthesis 1-(2-Bromoethoxy)-4-fluorobenzene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Synthelabo; US5246939; (1993); A;,
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