Tag: M.W=100-200

Synthetic Route of 50868-73-0,Some common heterocyclic compound, 50868-73-0, name is 2-Methoxy-6-methylaniline, molecular formula is C8H11NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of 2-methoxy-6-methylphenylaniline (137 mg) and diisopropylethylamine (0.38 mL) in anhydrous dichloromethane (5 mL) was added dropwise slowly to a solution of triphosgene (119 mg) in anhydrous dichloromethane (5 mL) at room temperature. After the dropwise addition was completed, a solution of 1-(2-methoxy-5-methyl-phenyl)-3-(4-piperazin-1-yl-phenyl)-urea (340 mg) obtained in Example (47a) and diisopropylethylamine (0.38 mL) in anhydrous dichloromethane (5 mL) was added dropwise slowly to the reaction mixture at room temperature. After 3 hours, the reaction mixture was concentrated and diluted with ethyl acetate and water. The deposited solid was collected by filtration, washed with hexane and ethyl acetate and dried under reduced pressure, and 361 mg (72%) of the title compound was obtained as a white powder. 1H-NMR spectrum (400MHz,DMSO-d6):delta(ppm)=9.10(1H, s), 8.07(1H, s), 7.99(1H, d, J=1.5Hz), 7.77(1H, s), 7.34(2H, d, J=8.6Hz), 7.10(1H, dd, J=7.9 and 7.9Hz), 6.96(2H, d, J=9.0Hz), 6.96(1H, d, J=9Hz), 6.88(1H, dd, J=7.4 and 7.4Hz), 6.82(1H, dd, J=8.4 and 8.4Hz), 6.72(1H, d, J=8.2Hz), 3.84(3H, s), 3.73(3H, s), 3.59(4H, t, J=4.1Hz), 3.07(4H, t, J=5.1Hz), 2.23(3H, s), 2.12(3H, s). MS(FAB) m/z:504 (M + H)+. Melting point: 200-203C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Methoxy-6-methylaniline, its application will become more common.

Application of 67191-35-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 67191-35-9, name is 1-Isopropoxy-2-vinylbenzene, This compound has unique chemical properties. The synthetic route is as follows.

A flame-dried Schlenk reaction flask is charged with a stir bar and put under an Ar atmosphere. 923 mg [Dichloro-(3-phenyl-1H-inden-1-ylidene)-bis-(tricyclohexyl-phosphine)-ruthenium(II)] 2a (1.0 mmol; Umicore AG & Co KG, Hanau), 173 mg 2-isopropoxystyrene (1.05 mmol; 1.05 equiv.; Aldrich) and 1026 mg Amberlyst 15-A resin in dry form (4.0 mmol, 4 equiv.; Rohm and Haas Co., Philadelphia, USA) are loaded into the reaction flask and 25 mL dichloromethane (DCM) is added. The reaction is stirred at 40 C. for 75 minutes and the solution colored from red to brown. Subsequently, the reaction mixture is sent through a Pasteur pipette equipped with a cotton plug to remove the Amberlyst resin. Evaporation of all volatiles, suspending the residue in 20 mL n-hexane and subsequent filtration and drying of the precipitate in vacuo afforded 548 mg of the desired compound 3a (yield: 91%)

The chemical industry reduces the impact on the environment during synthesis 1-Isopropoxy-2-vinylbenzene. I believe this compound will play a more active role in future production and life.

Synthetic Route of 910251-11-5, The chemical industry reduces the impact on the environment during synthesis 910251-11-5, name is Potassium trifluoro(methoxymethyl)borate, I believe this compound will play a more active role in future production and life.

A vial was charged with (8-bromo-5,ll -dihydro-6H-pyrido [2,3-b] [1,5 ]benzodiazepin-6- yl)Qrans-4-methoxycyclohexyl)methanone (25 mg, 0.060 mmol), potassium trifluoro(methoxymethyl)borate (11 mg, 0.075 mmol), mesylate[(di( 1 -adamantyl)-nbutylphosphine)-2-(2?-amino- 1,1 ?-biphenyl)]palladium(II), [(di( 1 -adamantyl)-butylphosphine)-2- (2?-amino-l,l?-biphenyl)]palladium(II) methanesulfonate (4.4 mg, 6.0 jimol) and cesiumcarbonate (59 mg, 0.18 mmol). The solids were dissolved in 2-methyl-2-butanol (0.5 mL) andwater (0.125 mL), the reaction was purged under argon for 5 minutes, and then heated to 70C for 18 h. The reaction was then allowed to cool to room temperature and concentrated under reduced pressure. The residue was filtered and purified by mass triggered reverse phase HPLC (ACN/water with 0.1% TFA modifier) to afford the title compound as a solid TFA salt. MS: 382 (M + 1). ?H NMR (600 MHz, DMSO-d6) oe 9.61 (s, 1H), 8.04 – 8.00 (m, 1H), 7.51 (d, J= 7.1 Hz,1H),7.29-7.26(m, 1H),7.19-7.16(m,2H),6.76-6.71 (m, 1H),5.17 (d,J= 15.0Hz, 1H),4.33 (s, 2H), 3.88 (d, J 14.9 Hz, 1H), 3.20 (s, 3H), 3.09 (s, 3H), 2.95 – 2.85 (m, 1H), 2.38 -2.31 (m, 1H), 1.98-1.90 (m, 1H), 1.84- 1.79 (m, 1H), 1.76- 1.70 (m, 1H), 1.48-1.37 (m,1H), 1.17- 1.08 (m, 1H), 0.99 -0.90 (m, 1H), 0.86- 0.76 (m, 1H), 0.62- 0.51 (m, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Potassium trifluoro(methoxymethyl)borate, other downstream synthetic routes, hurry up and to see.

Related Products of 33170-72-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 33170-72-8 as follows.

[0322] To a stirred solution of iV-hydroxy-6-methoxy-5-(4-methyl- 1H-imidazol- 1-yl) picolinimidamide (1 g, 4 mmol) in DMSO (5 mL) at 0 C under an argon atmosphere were added potassium hydroxide (272 mg, 5 mmol) and 2-bromo-1,1-dimethoxypropane (814 mg, 4 mmol). The reaction mixture was warmed to room temperature and stirred for 24 h. After consumption of the starting material (monitored by TLC), the reaction mixture was diluted with ice cold water (30 mL) and extracted with EtOAc (2 x 30 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo to obtain N-((1,1- dimethoxypropan-2-yl) oxy)-6-methoxy-5-(4-methyl- 1 H-imidazol- 1 -yl) picolinimidamide Example 3 (300 mg, crude) as an off-white solid used in the next step without further purification. LCMS: 46.2%; 349.9 (M+1); (column; Ascentis Express C-18 (50 x 3.0 mm, 2.7tim); RT 1.63 mm; mobile phase: 0.025% Aq TFA+5% ACN: ACN+5% 0.025% Aq TFA; T/B%: 0.01/5, 0.5/5, 3/100, 5/100; flow rate: 1.2 mL/min) (Gradient); TLC: 30% EtOAc/ hexane (Rj: 0.6)

According to the analysis of related databases, 33170-72-8, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 2734-70-5, name is 2,6-Dimethoxyaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2734-70-5, Quality Control of 2,6-Dimethoxyaniline

Acetic anhydride (2.97 mL, 31.45 mmol) was added to a solution of aniline 51 (2.19 g, 14.3 mmol) in dry dichloromethane (50 mL) under inert atmosphere. The reaction was stirred at room temperature for 24 hours. Upon completion, the reaction mixture was washed with a saturated solution of sodium carbonate, the organic layer dried over MgSO4 and the solvent removed under reduced pressure. The acetanilide 52 was obtained as a white solid (1.67 g, 60percent) after crystallization from Et2O; mp (Et2O) 128-130 °C; TLC Rf (EtOAc) = 0.37; 1H NMR (CDCl3, 400 MHz) delta (ppm) 2.20 (large s, 3H, NHCOCH3), 3.84 (s, 6H, 2OCH3), 6.42 (large s, 1H, NHCOCH3), 6.59 (d, J = 8.4 Hz, 2H, ArH), 7.20 (t, J = 8.2 Hz, 1H, ArH). 13C NMR (CDCl3, 100 MHz) delta 23.3 (CH3), 55.9 (2CH3), 104.3 (2CH), 107.4 (C), 127.8 (CH), 155.6 (2C), 172.9 (C). IR nu cm-1: 1104, 1253, 1437, 1474, 1537, 1590, 1651, 3184, 3256. Calcd. for C10H13O3N: C, 61.53; H, 6.71; N, 7.17. Found: C, 61.36; H, 6.94; N, 7.01.

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Electric Literature of 41864-45-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 41864-45-3, name is 4,5-Dimethoxy-2-methylaniline, This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 18 N2-(4,5-Dimethoxy-2-methylphenyl)-N4-(5-adamantylisoxazol-3-yl)-2,4-pyrimidinediamine The title compound was prepared by the method described in Example 1 using 2-chloro-N4-(5-adamantylisoxazol-3-yl)-4-pyrimidineamine and 2-methyl-4,5-dimethoxyaniline. MS (MH+)=462.2; Calc’d for C26H31N5O3-461.57. Other compounds included in this invention are set forth in Tables 1-2 below.

The chemical industry reduces the impact on the environment during synthesis 4,5-Dimethoxy-2-methylaniline. I believe this compound will play a more active role in future production and life.

Related Products of 54149-17-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 54149-17-6, name is 1-Bromo-2-(2-methoxyethoxy)ethane belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: DBU (4.5mmol) and 1-bromo-2-methoxyethane or 1-(2?-methoxyethoxy)-2-bromoethane were added to a solution of a triterpenic acid 1, 2, 3, 4 (2.2mmol) in the mixture of CH2Cl2 (6mL) and MeCN (2mL). The reaction mixture was stirred for 2 days at room temperature. The work-up (A), column chromatography on silica gel, and crystallization afforded final products 1a – 3a and 1b – 3b.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2-(2-methoxyethoxy)ethane, other downstream synthetic routes, hurry up and to see.

Related Products of 33311-29-4, The chemical industry reduces the impact on the environment during synthesis 33311-29-4, name is 4-(2-Methoxyethoxy)aniline, I believe this compound will play a more active role in future production and life.

The 4-(2-methoxyethoxy)aniline used as starting material was obtained as follows: Potassium tert-butoxide (2 g) was added portionwise to a stirred mixture of 4-fluoronitrobenzene (2.8 g), 2-methoxyethanol (10 ml) and DMF (20 ml). The mixture was stirred and heated to 60 C. for 4 hours. The mixture was diluted with water and extracted with ethyl acetate. The organic phase was washed with water and with brine, dried (MgSO4)- and evaporated. The residue was recrystallized from a mixture of hexane and ethyl acetate. There was thus obtained 4-(2-methoxyethoxy)nitrobenzene (1.06 g), m.p. 86 C. The product so obtained was dissolved in ethyl acetate and hydrogenated in the presence of a 10% Pd/C catalyst to give 4-(2-methoxyethoxy)aniline (0.7 g). NMR Spectrum: (CD3 SOCD3) 3.3 (s, 3H), 3.6 (t, 2H), 3.9 (t, 2H), 4.6 (s, 2H), 6.5 (d, 2H), 6.7 (d, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(2-Methoxyethoxy)aniline, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 102503-23-1, name is 1-(2,4-Dimethoxyphenyl)-N-methylmethanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 102503-23-1, HPLC of Formula: C10H15NO2

Sodium hydride (60% in oil, 2.23 g, 55.8 mmol) was washed twice with n-hexane and suspended in THF (180 mL). A solution of 1-(2,4-dimethoxyphenyl)-N-methylmethanamine (9.09 g, 50.2 mmol) in THF (10 mL) was added dropwise to this suspension at 0 C, and then the mixture was stirred at 60 C for 18 h. After cooled to 0 C, a solution of compound 15 (9.64 g, 45.4 mmol) in THF (10 mL) was added dropwise, and then the mixture was stirred at the same temperature for 1 h. Ice-cooled solution of NaCl were added, and the mixture was extracted with EtOAc. The extract was washed successively with a solution of NH4Cl, a solution of NaHCO3, H2O and brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by basic silica gel column chromatography (EtOAc) to obtain compound 16 (16.8 g, 99%) as a yellow oil. 1H-NMR (CDCl3) d 2.24 (3H, s), 3.51 (2H, s), 3.54 (2H, s), 3.79 (3H, s), 3.80 (3H, s), 6.45 (1H, s), 6.42-6.50 (1H, m), 6.68 (1H, dd, J = 4.7 Hz, 3.6 Hz), 7.18-7.29 (2H, m), 7.98 (1H, ddd, J = 4.5 Hz, 1.9 Hz, 1.5 Hz), 8.25 (1H, ddd, J = 10.2 Hz, 8.0 Hz, 1.9 Hz), 8.67 (1H, s).

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Related Products of 3616-56-6, These common heterocyclic compound, 3616-56-6, name is 2,2-Diethoxy-N,N-dimethylethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Synthesis example B6: Synthesis of 12H-benzofuranyl[3,2-a]carbazole (compound 6); (6); Compound 5 (2.8 g, 1 eq.) is added to acetic acid (30 ml) and heated to reflux. (Dimethylamino)acetaldehyde diethyl acetal (95percent; 20.3 g, 10 eq.) is added dropwise in portions to the solution. The reaction is stirred at reflux overnight. Then further (dimethylamino)acetaldehyde diethyl acetal (95percent; 2.0 g) is added and stirred further at reflux after 3 h. Subsequently, the flask contents are diluted with CH2CI2 at room temperature and washed in a separating funnel with distilled water and NaCI (saturated). Organic phase is dried with Na2S04 and concentrated. LC (Si02, 15:85 ethyl acetate/cyclohexane) gives the product 6 (1 .92 g, 62.2percent yield).1 H NMR (CD2CI2, 400 MHz): “5 = 8.88 (br s, 1 H), 8.16 (d, 1 H), 8.12 (d, 2H), 7.66 (d, 1 H), 7.62 (d, 1 H), 7.42-7.53 (m, 4H), 7.31 (dd, 1 H).

The synthetic route of 3616-56-6 has been constantly updated, and we look forward to future research findings.