Month: December 2020

Synthetic Route of 104-92-7, The chemical industry reduces the impact on the environment during synthesis 104-92-7, name is 1-Bromo-4-methoxybenzene, I believe this compound will play a more active role in future production and life.

General procedure: To a stirred solution of 1.0 mmol of aryl halide in 4 mL of DMF,1.0 mmol of terminal alkyne, 1.5 mmol of piperidine and 0.2 mol%of Pd/Fe3O4NPs were added and the mixture was heated on anoil bath at 110C for 24 h under inert atmosphere (N2). After com-pletion of the reaction (as monitored by TLC), the reaction mixturewas cooled to room temperature and the catalyst was separatedusing a magnetic separator. The solvent was evaporated at reducedpressure, and the residue was subjected to gel permeation chro-matography to afford pure products. All the products are knowncompounds and the spectral data and melting points were identicalto those reported in the literature

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-methoxybenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Nasrollahzadeh, Mahmoud; Mohammad Sajadi; Rostami-Vartooni, Akbar; Khalaj, Mehdi; Journal of Molecular Catalysis A: Chemical; vol. 396; (2015); p. 31 – 39;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 1516-96-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1516-96-7, name is 5-Bromo-1,3-di-tert-butyl-2-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.

Under nitrogen protection, to a 250 mL dry 3-necked round bottom flask equipped with a magnetic stirrer and thermometer was added:THE was added dropwise to the solution of the residue prepared above under nitrogen at 0C. After stirring another 1.5h at room temperature, the mixture was quenched withwater at 0C and extracted three times withdichloromethane. The combined organic layers were dried over Na2504 and concentrated in vacuo. The residue was purified by flash chromatography on silica gel, eluting with petroleum ether/ethyl acetate = 75:25, to give product as a white solid (1.94 g, 81% yield).1.0 g tetraethyl (((2R)-propane-1,2-diylbis(oxy))bis(3,1-phenylene))bis(phosphonate) (2.0 mmol, 1.0 equiv.) in3.0 mL thionyl chloride (40.0 mmol, 20.0 equiv.) under nitrogen was added30.0 iL dimethylformamide (0.4 mmol, 0.2 equiv). The mixture was stirred under reflux for 18 h, during which time15.0 iL dimethylformamide (all together 8.0 mmol, 0.3 equiv.) was added after 12h. After the solvent was evaporated, the residue was dissolve in5.0 mL THE and concentrated in vacuo (once). The residue was used for the next step without further purification.To a phenyl magnesium bromide solution prepared from a suspension of0.53g magnesium turning (22.0 mmol, 11.0 equiv.) and6.0 g 5-bromo-1,3-di-tert-butyl-2-methoxybenzene (20.0 mmol, 10.0 equiv.) in20.0 mL10.0 mL50 mL

The chemical industry reduces the impact on the environment during synthesis 5-Bromo-1,3-di-tert-butyl-2-methoxybenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; DSM IP ASSETS B.V.; BONRATH, Werner; FENG, Zheng-Chuan; MEDLOCK, Jonathan, Alan; PENG, Kun; ZHU, Zhibin; (28 pag.)WO2018/189107; (2018); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 35822-58-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35822-58-3, name is 2-Bromobenzaldehyde diethyl acetal, This compound has unique chemical properties. The synthetic route is as follows.

To a cooled solution of 5 g (1 9.3 mmol) of 1 -bromo-2-(diethoxymethyl)benzene in 40 mL of diethylether, are slowly added 12 mL (1 9.3 mmol) of a 1 .6 M solution of butyllithium. The reaction mixture is stirred at ambient temperature for 1 hr. After slow addition of 4.28 g (25 mmol) of chloro(dimethyl)phenylsilane, the reaction mixture is further stirred for 2 hrs at ambient temperature, then poured over a mixture of ice and 40 mL of 1 N HCI and stirred overnight. The watery layer is extracted with 2 x 50 mL of ethyl acetate. The organic layer is washed twice by a concentrated aqueous solution of NaCI and dried over magnesium sulfate to yield after concentration, 5.45 g of a yellow oil. Column chromatography on silica gel (gradient n-heptane/ethyl acetate) yields 4.65 g (100% yield) of 2-[dimethyl(phenyl)silyl]benzaldehyde as a colorless oil. (M+H = 241 ).

The chemical industry reduces the impact on the environment during synthesis 2-Bromobenzaldehyde diethyl acetal. I believe this compound will play a more active role in future production and life.

Reference:
Patent; BAYER CROPSCIENCE AG; CRISTAU, Pierre; DESBORDES, Philippe; ES-SAYED, Mazen; GROSJEAN-COURNOYER, Marie-Claire; LACHAISE, Helene; RINOLFI, Philippe; SCHMIDT, Jan-Peter; TSUCHYIA, Tomoki; VORS, Jean-Pierre; WO2013/156560; (2013); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 332-48-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 332-48-9, name is 1-(2-Bromoethoxy)-4-fluorobenzene, This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 2 Compound No. 2 2-[1-[2-(4-Fluorophenoxy)ethyl]piperidin-4-ylamino]pyrimidine-4-carboxamide, hydrochloride. 2.1 8-[2-(4-Fluorophenoxy)ethyl]-1,4-dioxa-8-azaspiro-[4.5]decane. 21.91 g (0.1 mol) of 2-(4-fluorophenoxy)ethyl bromide, 14.32 g (0.1 mol) of 1,4-dioxa-8-azaspiro[4.5]decane and 20.73 g (0.15 mol) of potassium carbonate are introduced into 250 ml of 2-butanone and the mixture is heated at boiling for 7 hours. The mixture is cooled to room temperature, filtered, the insoluble material washed with 200 ml of ether and the solvents evaporated under reduced pressure. 29 g of a yellow oil are obtained which is used as it is in the following stage.

The chemical industry reduces the impact on the environment during synthesis 1-(2-Bromoethoxy)-4-fluorobenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Synthelabo; US5246939; (1993); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 1758-46-9,Some common heterocyclic compound, 1758-46-9, name is 2-Phenoxyethylamine, molecular formula is C8H11NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution OF 5- (3APOS;-CARBOXY-4-METHOXY-1, 1APOS;-BIPHEN-3-YL)-1, 2,5-thiadiazolidin-3-one 1, 1-dioxide (Example 43) (0.05 g, 0.14 mmol, 1 eq. ) and DIPEA (24 L, 0.14 mmol, 1 eq. ) in DCM (2mL) added HOBt (19 mg, 0.14 mmol, 1 eq. ), 2-phenoxyethylamine (18 RL, 0.14 mmol, 1 eq. ) and EDCI (31 mg, 0.17 mmol, 1.2 eq. ). The reaction was allowed to stir at ambient temperature overnight and then the solvent was removed under reduced pressure. The residue was taken up in acetonitrile: water (1: 1,3 mL) and purified by reverse phase preparative HPLC to afford the title compound as a colourless solid (0.04 g, 60percent yields

The synthetic route of 1758-46-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2004/41799; (2004); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 607-58-9, These common heterocyclic compound, 607-58-9, name is 1-(Benzyloxy)naphthalene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Palladium acetate (3.4 mg, 0.015 mmol, 5 mol%) and sodium hydride (60% in oil, 18 mg, 0.45 mmol, 1.5 equiv) were suspended in DMA (1.0 mL) under nitrogen.After stirring at 25 C for 5 minutes, a solution of Compound 1 (0.3 mmol) in DMA (0.5 mL) was added, followed by a reaction at 50 C for 5 hours.The reaction was stopped by adding ice water, the pH was adjusted to 3.5 with dilute hydrochloric acid, and extracted with ethyl acetate.Drying with sodium sulfate, rotary evaporation and purification by column chromatography gave product 2, yield 98%.

The synthetic route of 607-58-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Soochow University (Suzhou); Zhang Shilei; Liu Ye; Mao Yujian; Gui Jingjing; Sun Wanwan; Wang Liudi; (15 pag.)CN108358760; (2018); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3401-47-6, name is 1-Bromo-2-methoxynaphthalene, A new synthetic method of this compound is introduced below., Product Details of 3401-47-6

(A) 2-Acetyl-5-bromo-6-methoxy-naphthalene (Compound V) A suspension of 43 g of anhydrous AlCl3 and 24.6 g (0.313 mole) of acetyl chloride in 200 ml of 1,2-dichloroethane at 10 C. was cooled to 0 C. and added dropwise under stirring with a solution of 59.25 g (0.250 mole) of 1-bromo-2-methoxy-naphthalene in 150 ml of 1,2-dichloroethane. The resulting solution was stirred for 15 minutes then poured into a cold solution of 300 ml of water and 100 ml of 2 N hydrochloric acid. The organic phase was separated, washed first with 100 ml of 1 N hydrochloric acid and then with 100 ml of water, dried under vacuum and the obtained residue was crystallized from 2-butanol. Yield 68.11 g (98%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Alfa Chemicals Italiana S.p.A.; US4423244; (1983); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 876-32-4 as follows. name: 4-Methoxy-N-methylbenzylamine hydrochloride

In a sealed tube, mixture of benzamide 3a (38 mg, 0.11 mmol), formaldehyde (37% in water, 0.043 mL, 0.55 mmol), l-(4-methoxyphenyl)-N-methylmethanamine hydrochloride (102 mg, 0.55 mmol), and 1 N NaOH (0.5 mL) in H2O:THF (1 mL: 0.5 mL) was heated at 65 C for 2 hours. After cooling to room temperature, the reaction mixture was diluted with ethyl acetate, washed with brine, dried over Na2S04, and concentrated, then purified by column chromatography to afford the pure product (28 mg, 51% yield) as off white solid. 1H NMR (CDCI3, 300 MHz) 6: 8.00 (d, J= 1.8 Hz, 1H), 7.82 (d, J= 8.7 Hz, 1H), 7.40 (dd, J= 2.1, 8.7 Hz, 1H), 7.23 (d, J= 8.7 Hz, 2H), 7.14- 7.07 (m, 1H), 6.90-6.83 (m, 1H), 6.85 (d, J= 7.8 Hz, 2H), 6.20 (bs, 1H), 5.50 (s, 2H), 4.39 (d, J= 6.3 Hz, 2H), 3.79 (s, 3H), 3.60 (s, 2H), 2.33 (s, 3H).

According to the analysis of related databases, 876-32-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY; LAVOIE, Edmond J.; PARHI, Ajit; ZHANG, Yongzheng; PILCH, Daniel S.; KAUL, Malvika; WO2013/142712; (2013); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 171290-52-1, name is 3,5-Dimethoxyphenylacetylene, A new synthetic method of this compound is introduced below., Application In Synthesis of 3,5-Dimethoxyphenylacetylene

Formula 7 of the azide compound (300 mumol), alkynyl (750 mumol), CuSO4 (9.6 mg, 60 mumol) and Na. An ascorbate (60.0 mg, 300 mumol) 1: was dissolved in 1 t-BuOH / H2O (3 mL). The mixture was stirred at room temperature for 2 hours. After the reaction was completed, the mixture was filtered of and washed using H2O (70 mL) (solid A). The filtrate was extracted with EtOAc (3 ¡Á 70 mL). The combined organic extracts were then dried using anhydrous MgSO4, filtered and concentrated by rotaryevaporation (residue B). It was combined and the solid residue A and B, was purified by column chromatography to give the compound of formula 2 and 3. Following the general method for the general formula 2, 1: 1 t-BuOH / H2O in the compound (3 mL) 7f (34.6 mg, 100 mumol), 1-Ethynyl -3,5-dimethoxy-benzene (40.1 mg, 250 mumol), CuSO4 (3.2 mg, 20 mumol) and Na. Using ascorbate (20.0 mg, 100mumol) was prepared the desired compound. The reaction mixture was stirred at room temperature for 3.5 h, purified by column chromatography (5: 1 hexane / EtOAc ? 20: 1 CH2Cl2 / MeOH) to use the compound 2f was obtained as a brown solid (39.7mg, 82%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; EWHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION; YOO, JAE SANG; SONG, DOO HUI; (33 pag.)KR2015/134731; (2015); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 4393-09-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4393-09-3, name is (2,3-Dimethoxyphenyl)methanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

(g) By proceeding in a manner similar to Reference Example 2(a) but using 2,3-dimethoxy-benzylamine, there was prepared 3-(2.3-dimethoxy-benzylamino)-propionic acid ethyl ester.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (2,3-Dimethoxyphenyl)methanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Aventis Pharma Limited; US6352977; (2002); B1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem