Tag: M.W=100-200

Electric Literature of 20781-20-8, These common heterocyclic compound, 20781-20-8, name is (2,4-Dimethoxyphenyl)methanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of compound 58 (6.6 g, 33.5 mmol) in dichloromethane (100 mL)were added DIPEA (8.65 g, 67 mmol), HOBt (5.4 g, 36.85 mmol) and EDCI (9.6 g, 50.3mmol). After about 15 mm stirring, to the homogeneous reaction mixture was added asolution of 2,4-dimethoxybenzyl amine (5.6 g, 33.5 mmol) in dichloromethane (50 mL)dropwise under nitrogen atmosphere. The resulting mixture was stirred under nitrogenatmosphere at room temperature for 16h. The reaction mixture was washed successively with iN NaOH (100 mL), water (100 mL) and brine (100 mL). The organic phase was then dried over Na2SO4 and evaporated to give a crude solid product 59 that crystallized from ethyl ether. Filtration and open air suction drying afforded an off-white solid pureproduct 9.8g (96%), (MS: [M+1] = 347).

Statistics shows that (2,4-Dimethoxyphenyl)methanamine is playing an increasingly important role. we look forward to future research findings about 20781-20-8.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3616-56-6, name is 2,2-Diethoxy-N,N-dimethylethanamine, A new synthetic method of this compound is introduced below., Recommanded Product: 2,2-Diethoxy-N,N-dimethylethanamine

The mixture of homocoupling product 2i (0.5 mmol), NaOEt (340.25 mg, 5.0 mmol) and DMSO (1.0 mL) was added into a 35 ml pressure-resistant vial under air atmosphere. The mixture was heated to 120oC and stirred for 5h. After being cooled to ambient temperature, the reaction mixture was diluted with EtOAc (60 mL) and washed with H2O (2×30 mL). The aqueous phase was extracted with EtOAc (2×30 mL), and the combined organic phase was dried over anhydrous Na2SO4, filtered and concentrated under the reduced pressure. The residue was purified by silica gel column directly to give the product 3i (Yield 82%). The spectra of 3i were in accordance with those reported in the literature3. Then 16.1mg (1.0 mmol) (dimethylamino)acetaldehyde diethyl acetal was added in the refluxing mixture of 30 mg (0.10 mmol) biindole 3i with the 3ml of AcOH solvent. The resulting mixture was refluxed for 2 h, then cooled to room temperature, and concentrated under reduced pressure. The residue was purified by silica gel chromatography to give tjipanazole D (4i) with 65% yield (21.1 mg). The spectra of 4i were in accordance with those reported in the literature3,4,5.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 126-38-5,Some common heterocyclic compound, 126-38-5, name is 1-Bromo-2,2-dimethoxypropane, molecular formula is C5H11BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The compound 4,6-dimethoxypyrimidine-5-carboxamide (500 mg, 2.73 mmol) was suspended in1-bromo-2,2-dimethoxypropane (5 mL),The mixture was heated to 130 C and stirred for 1.5 hours. The reaction was monitored by thin-layer chromatography (PE / EtOAc, v / v, 2/1). After the reaction was completed, the reaction mixture was diluted with ethyl acetate (30 mL). The resulting mixture was washed with water (30 mL) and brine (30 mL), and the organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (PE / EtOAc (v / v) = 8/1) to give the title compound as a white solid (229 mg, 37.9%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-2,2-dimethoxypropane, its application will become more common.

Related Products of 1978-39-8,Some common heterocyclic compound, 1978-39-8, name is 5-Fluoro-2-methoxyaniline, molecular formula is C7H8FNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 2 (5) obtained in 2 – [[5- (4-hydroxy-3-methoxyphenyl)-4-(lH-pyrrol-1-yl)-4H-1,2,4-triazole -3 – yl] thio] acetic acid (200mg, 0.58mmol),1-hydroxybenzotriazole (80mg, 0.6mmol),1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (120 mg, 0.6 mmol)Of N, N-dimethylformamide (4 ml)Was added triethylamine (0.18ml, 1.2mmol)When the 5-fluoro-2-methoxy aniline (0.08ml, 0.7mmol)Was stirred for 16 hours at room temperature added.It was extracted by the addition of 1N hydrochloric acid and ethyl acetate to the reaction solution. Further, the aqueous layer was extracted twice with ethyl acetate, the organic layer was dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, the residue was purified by column (hexane: ethyl acetate = 1: 3-1: 5) to give N-(5-fluoro-2-methoxyphenyl) -2 – [[5- ( 4-hydroxy-3-methoxyphenyl) -4- (1H- pyrrol-1-yl) -4H-1,2,4- triazol-3-yl] thio] acetamide (30mg, 11%) a pale brown solid It was obtained as a.

The synthetic route of 1978-39-8 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 707-07-3, name is (Trimethoxymethyl)benzene, A new synthetic method of this compound is introduced below., Formula: C10H14O3

General procedure: To a stirred solution of the respective N-carbamate protected aminoalcohol 1 (0.50 mmol, 1 equiv) in CH2Cl2 (10 mL, 0.05 M) were added BF3·OEt2 (50 muL, 0.050 mmol, 0.1 equiv or 150 muL, 0.15 mmol, 3 equiv, 1.0 M solution in CH2Cl2) and trimethyl orthobenzoate (0.13 mL, 0.75 mmol, 1.5 equiv) at r.t. The resulting mixture was stirred at r.t. under N2 until TLC showed complete conversion of the substrate. The reaction was quenched with sat. aq NaHCO3 and extracted with EtOAc(2 ×). The combined organic layers were washed with brine, dried(MgSO4), filtered, and concentrated in vacuo. The residue was purified by flash chromatography on silica gel (hexane/EtOAc) to give the desired product 2.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 768-70-7, name is 3-Ethynylanisole, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 768-70-7, Computed Properties of C9H8O

General procedure: A mixture of CuII(BAPTE)Cl2-[n-Bu4N]4[Mo6O18]2 (1mol%, 30mg) in H2O/DMSO (3mL, 1:10) was stirred for 10min. Then, the phenylacetylenes (1.3mmol), benzyl halide (1mmol), sodium azide (1.1mmol) and sodium ascorbate (5mol%) were added, and the resulting mixture was stirred at room temperature. The progress of the reaction was monitored by TLC (eluting with n-hexane/ethyl acetate, 1:1). At the end of the reaction, methanol (5mL) was added to precipitate the catalyst. The catalyst was recovered by centrifugation, washed with methanol and diethyl ether, and dried in vaccuo. The filtrates were concentrated and the pure product was obtained by thin layer chromatography.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Ethynylanisole, and friends who are interested can also refer to it.

Application of 171290-52-1, These common heterocyclic compound, 171290-52-1, name is 3,5-Dimethoxyphenylacetylene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of the azide intermediate (0.1 mmol) in 0.2 mL of DMFin a microwave tube, CuSO4 (0.05 mmol) diluted in 50.0 muL of water,sodium ascorbate (0.025 mmol) and the alkyne (0.2 mmol) were added.The tube was sealed and the solution was irradiated (70 C, 150 W) for10 min and, then, TLC analysis showed the complete consumption ofthe starting material. The reaction was diluted with 15 mL of brine,extracted with ethyl acetate (3×10 mL), dried by anhydrous Na2SO4and concentrated under reduced pressure. The resulting crude productwas purified by column chromatography on silica gel [hexane: ethylacetate, 60:40% (v/v)] yielding the expected product.

Statistics shows that 3,5-Dimethoxyphenylacetylene is playing an increasingly important role. we look forward to future research findings about 171290-52-1.

Some common heterocyclic compound, 456-49-5, name is 1-Fluoro-3-methoxybenzene, molecular formula is C7H7FO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C7H7FO

The 3-fluoro anisole (15 g, 119 mmol) was placed in THF (300 mL) and cooled to about -78 C., and then n-BuLi (89 mL 1.6 M in hexanes) was added while maintaining the temperature at around -70 C. The mixture was stirred for about 15 minutes, and bromine (18.9 g, 119 mmol) was added over 10 minutes. The mixture was warmed to r.t. and stirred overnight. The mixture was quenched with water, diluted with ether (500 mL) and partitioned between water/ether (1/1 300 mL). The water layer was back extracted with ether (250 mL), and the combined organic fractions were dried, filtered and concentrated. The dark residue was distilled under house vacuum (product 115-130 C.) to recover about 13.8 g of the product as a gray oil (57%/).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 456-49-5, its application will become more common.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7252-83-7, name is 2-Bromo-1,1-dimethoxyethane belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 7252-83-7

As described by Doel et al.,13 a solution of adenine or thymine (1 equiv) and K2CO3 (1 equiv) in DMF (10 mL) was stirred at 100 C in the presence of 2-bromo-1,1-dimethoxyethane (1.1 equiv). After 24 h, the reaction was filtered and the solvent removed under reduced pressure. The crude mixture was purified by column chromatography in silica gel with MeOH: CH2Cl2 or EtOAc: hexane as mobile phase. Corresponding 9-(2,2-dimethoxyethyl)-adenine and 1-(2,2-dimethoxyethyl)-thymine were obtained in 61% and 38% isolated yields respectively. Both acetals were completely hydrolyzed after 1 h stirring in HCl 1 N at 90 C, to yield the corresponding aldehydes.20

The synthetic route of 7252-83-7 has been constantly updated, and we look forward to future research findings.

Reference of 38336-04-8,Some common heterocyclic compound, 38336-04-8, name is 2-(Benzyloxy)-1-ethanamine, molecular formula is C9H13NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Ethyl 2-(4-chloro-3-nitrophenyl)-2-methylpropanoate (3a)(16.15 g, 0.0594 mol), 4 (27.77 g, 0.149 mol), K2CO3 (28.69 g,0.208 mol), KI (0.99 g, 5.94 mmol), TBAB (1.91 g, 5.94 mmol) and150 mL DMSO were added into a round-bottomed flask. The mixturewas heated to 120 C for 24 h then cooling to room temperature.The reaction mixture was diluted with saturated NH4Claqueous solution (250 mL) and extracted with CH2Cl2 (450 mL).The combined organic layer was washed with brine (300 mL), driedover anhydrous sodium sulfate, filtered, and concentrated in vacuo.The residue was purified by silica gel column chromatography (PE:EtOAc = 4:1) to give compound 5a (15.82 g) as yellow oil in 69%yields. 1H NMR (300 MHz, CDCl3) d (ppm) 8.27 (s, 1H), 8.19 (d,J = 2.4 Hz, 1H), 7.41-7.30 (m, 5H), 6.84 (d, J = 9.0 Hz, 1H), 4.61 (s,2H), 4.13 (q, J = 7.1 Hz, 2H), 3.77 (t, J = 5.4 Hz, 2H), 3.53 (q,J = 5.3 Hz, 2H), 1.58 (s, 5H), 1.21 (t, J = 7.1 Hz, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(Benzyloxy)-1-ethanamine, its application will become more common.