Tag: M.W=200-300

Synthetic Route of 51388-20-6, A common heterocyclic compound, 51388-20-6, name is 4-(Benzyloxy)aniline hydrochloride, molecular formula is C13H14ClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Preparation XXV N-[4-(phenylmethoxy)phenyl]alanine ethyl ester A solution of 15 g (63.6 mmol) of 4-(phenylmethoxy)aniline hydrochloride in 200 ml of dimethylformamide is prepared and 13.8 g (76.4 mmol) of ethyl 2-bromopropionate are added, followed by 8.9 ml (63.6 mmol) of triethylamine. The reaction mixture is stirred for 24 h at 100 C. and then cooled and poured into 200 ml of iced water. The mixture is extracted with 2 times 200 ml of ethyl acetate and the combined organic phases are washed with water and then dried over sodium sulfate and concentrated under reduced pressure. The residue is purified by chromatography on silica gel using a cyclohexane/ethyl acetate mixture (95/5; v/v) as the eluent to give 10 g of the expected product in the form of an oil, which turns to beige crystals (yield=52%). M.p.=70 C.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

These common heterocyclic compound, 20469-65-2, name is 1-Bromo-3,5-dimethoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 20469-65-2

A 200-mL two-neck round-bottom flask was charged with anitrogen atmosphere, and to the flask, 1-bromo-3,5-dimethoxybenzene (2.92 g, 13.82 mmol), bis(pinacolato)diboron (5.26 g, 20.73 mmol), Pd(dppf)Cl2?CH2Cl2 (1.56 g, 1.91 mmol) and KOAc (2.10 g, 20.73 mmol) were added into 80 mL of dry DMF. The mixture was stirred at 80C for 60 h under nitrogen. Then, DMF was removed by vacuum distillation, and the residue was extracted with CH2Cl2 (3 20 mL). The CH2Cl2 layer was washed with H2O (2 x 20 mL), dried over anhydrous Na2SO4, filtered and concentrated in vacuo to give a brown crude. The crude product was purified by column chromatography on silica gel (eluent: EtOAc: hexane, 2/3 v/v) to give white compound as a first band. (1.16 g, 88%). 1H-NMR (500 MHz, DMSO) delta(ppm)= 6.95(2H, d, J= 2.6 Hz), 6.57 (1H, t, J= 2.5 Hz), 3.81 (6H, s), and 1.34 (12H, s).

The synthetic route of 1-Bromo-3,5-dimethoxybenzene has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4316-51-2, name is 4-Methoxytriphenylamine, A new synthetic method of this compound is introduced below., HPLC of Formula: C19H17NO

Example 14 Synthesis of 4-methoxy-4′,4″-diformyltriphenylamine: 5 g (18.16 mmol) of 4-methoxyltriphenylamine, 5.66 g (77.5 mmol) of N,N-dimethylformamide, 11.5 g (75.0 mmol) of phosphorus oxychloride, 2.5 g (18.3 nmmol) of zinc chloride, and 100 ml of toluene were subjected to reaction, post-treatment and isolation in the same manner as in Example 12. The results are set forth in Table 13. The reaction product exhibited the following physical properties:

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19056-41-8, name is 3-Bromo-4-methoxyaniline, A new synthetic method of this compound is introduced below., Application In Synthesis of 3-Bromo-4-methoxyaniline

Step b: 1-(Benzo[d][1,3]dioxol-5-yl)-N-(3-bromo-4-methoxyphenyl)-cyclopropane-carboxamide (B-10) To a Solution of the Crude 1-Benzo[1,3]Dioxol-5-yl-Cyclopropanecarbonyl Chloride (3.0 mmol) in CH2Cl2 (30 mL) at ambient temperature was added a solution of 3-bromo-4-methoxybenzenamine (3.3 mmol), Et3N (15 mmol), and CH2Cl2 (90 mL) dropwise. The mixture was allowed to stir for 16 h before it was diluted with CH2Cl2 (500 mL). The solution was washed with 1N HCl (2*250 mL), sat. aq. NaHCO3 (2*250 mL), then brine (250 mL). The organics were dried over Na2SO4, filtered, and concentrated in vacuo to provide 1-(benzo[d][1,3]dioxol-5-yl)-N-(3-bromo-4-methoxyphenyl)cyclopropanecarboxamide (B-10) with suitable purity to be used without further purification. Table 4 lists additional N-bromophenyl amides prepared according to preparation 9 and using appropriate starting materials.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 589-10-6, name is (2-Bromoethoxy)benzene, A new synthetic method of this compound is introduced below., Quality Control of (2-Bromoethoxy)benzene

4-hydroxy-1-indanone 1a (5 g, 33.78 mmol)Dissolved in 70 mL of acetonitrile,Potassium carbonate (8 g, 57.9 mmol)Phenoxyethyl bromide (8 g, 40 mmol) was added dropwise,85 stirring reaction 4h, the reaction is complete,The reaction solution was cooled to roomTemperature, filtration, concentration of filtrate under reduced pressure,Get black oil,And then dissolved in 100 mL of ethyl acetate, dried and dried, and purified by column chromatography (petroleum ether: ethyl acetate = 10: 1) to obtain intermediate product 1b(6.39 g, 23.85 mmol,White solid, the yield of 70.6%), directly into the next step.

The synthetic route of 589-10-6 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 14542-71-3, name is 3,5-Dibromo-4-methylanisole, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14542-71-3, Application In Synthesis of 3,5-Dibromo-4-methylanisole

Step A: 2,6-Dibromo-4-methoxy-benzyl bromide To a suspension of 5.0 g of 2,6-dibromo-4-methoxytoluene in 90 mL of CCl4 was added N-bromosuccinimide and benzoyl peroxide. The resulting mixture was heated to reflux and stirred at the refluxing temperature while irradiating with a sunlamp for 2 h, then cooled and concentrated. The resulting residue was dissolved in 1:1 hexanes-Et2O and filtered through a pad of silica gel, then purified by flash chromatography on a Biotage 40M column, eluding with 98:2 hexanes-Et2O, to yield 2,6-Dibromo-4-methoxy-benzyl bromide as a pale yellow solid. IH NMR (500 MHz, 2,6-Dibromo-4-methoxy-benzyl bromide as a pale yellow solid. 1H NMR (500 MHz,

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Dibromo-4-methylanisole, and friends who are interested can also refer to it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13940-96-0, name is 4-Phenoxybenzene-1,2-diamine, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 13940-96-0

20 ml of 6N HC1 was added to 1000 mg of 4-phenoxybenzene-l, 2-diamine in round bottom flask. Then add 500 pL of thioglycolicacid. This reaction mixture was refluxed for 4 hours. Excess solvent was evaporated under reduced pressure and to the remaining residue water (30 ml) was added and then extraction with ethyl acetate. The organic solvent was then dried over anhydrous MgS04 and evaporated under reduced pressure. The crude product was directly used in the next step without any further purification. LC.MS: m/z 257.06 (M+H)+.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 13940-96-0.

Electric Literature of 2357-52-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2357-52-0, name is 4-Bromo-2-fluoroanisole, This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 101 (2R)-1-(3-Fluorobiphenyl-4-yloxy)-4-(3-pyridyl)-2-butanol STR126 a) 3-Fluoro-4-methoxybiphenyl Prepared according to the method as described in Example 33a) from 4-bromo-2-fluoroanisole (1.0 g), benzeneboronic acid (0.6 g), tetrakis(triphenylphosphine)palladium(0) (0.12 g), toluene (15 ml), ethanol (3 ml) and aqueous sodium carbonate (2 M, 5 ml) with heating at 120 C. for 2 hours. After work up the residue was purified by chromatography over silica eluding with ethyl acetate:hexane (1:9) to give the sub-title compound as a white solid (0.99 g). m.p. 86-87 C. MS (EI) 202 (M)+ 1 H NMR (DMSO-d6) 7.65(2 H, dd); 7.55(1 H, dd); 7.5-7.4(3 H, m); 7.33(1 H, t); 7.25(1 H, t); 3.88(3 H, s).

The chemical industry reduces the impact on the environment during synthesis 4-Bromo-2-fluoroanisole. I believe this compound will play a more active role in future production and life.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4316-51-2, name is 4-Methoxytriphenylamine, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C19H17NO

Take compound I-TPA (4.40 g, 12.04 mmol)And purified DMF (31 mL) was added to a 100 mL round bottom flask and stirred at room temperature for 30 min until the compound I-TPA was completely dissolved.N-bromosuccinimide (2.84 g, 16 mmol) in portionsJoin the system,Stir at room temperature for 5 h. After the reaction is terminated,Diluted with dichloromethane and extracted with saturated brine until the aqueous phase was clear.MergedMachine phase, concentrated to no droplets,Chloroform / petroleum ether = 1/4 (v / v) as a rinse agent,Purified by silica gel column chromatography,The product was dried to a white oil, which was Intermediate 2-3, the actual yield was 4.70 g, and the yield was 75%.

According to the analysis of related databases, 4316-51-2, the application of this compound in the production field has become more and more popular.

Synthetic Route of 261762-35-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 261762-35-0, name is 5-Bromo-1,2-difluoro-3-methoxybenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Compound 1d (30mg, 128.04mumol), 5-bromo-1,2-difluoro-3-methoxybenzene (34.27mg, 153.65mumol), Pd (OAc) 2 (5.74mg, 25.61mumol), BINAP ( 31.89mg, 51.22mumol) and Cs2CO3 (105.00mg, 320.11mumol) were added in 5mL toluene, heated under N2 protection to 90 for 5h. After the reaction was completed, it was filtered through celite, and the filtrate was spin-dried and subjected to flash column chromatography (eluent system B) to obtain compound 1e (20 mg).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-1,2-difluoro-3-methoxybenzene, other downstream synthetic routes, hurry up and to see.