Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 589-10-6, name is (2-Bromoethoxy)benzene, A new synthetic method of this compound is introduced below., Quality Control of (2-Bromoethoxy)benzene
4-hydroxy-1-indanone 1a (5 g, 33.78 mmol)Dissolved in 70 mL of acetonitrile,Potassium carbonate (8 g, 57.9 mmol)Phenoxyethyl bromide (8 g, 40 mmol) was added dropwise,85 stirring reaction 4h, the reaction is complete,The reaction solution was cooled to roomTemperature, filtration, concentration of filtrate under reduced pressure,Get black oil,And then dissolved in 100 mL of ethyl acetate, dried and dried, and purified by column chromatography (petroleum ether: ethyl acetate = 10: 1) to obtain intermediate product 1b(6.39 g, 23.85 mmol,White solid, the yield of 70.6%), directly into the next step.
The synthetic route of 589-10-6 has been constantly updated, and we look forward to future research findings.