54149-17-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 54149-17-6, name is 1-Bromo-2-(2-methoxyethoxy)ethane belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a dimethylsalenium suspension (130 mL) of 2,7-dibromo (6.48 g, 20 mmol) (manufactured by Tokyo Chemical Industry Co., Ltd.), potassium hydroxide (5.61 g, 100 mmol) (0.33 g, 2 mmol) and 1-bromo-2- (2-methoxyethoxy) ethane (8.05 g, 44 mmol) and stirred at room temperature for 24 hours. After completion of the reaction, the mixture was cooled to 0 C, and water (120 mL) was added thereto, followed by neutralization with hydrochloric acid. The organic layer was extracted with ethyl acetate and dried over magnesium sulfate. The crude product was concentrated and purified by silica gel column chromatography (eluent: eluent / ethyl acetate (4/1 – & gt; 3/1)) to give Compound 1 (yield 8.47 g, yield: yellow liquid)80%).
The synthetic route of 1-Bromo-2-(2-methoxyethoxy)ethane has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NISSAN CHEMICAL INDUSTRIES, LTD.; OTA, HIROFUMI; ENDO, TOSHIYUKI; (63 pag.)TW2016/2059; (2016); A;,
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