Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 366-99-4, name is 3-Fluoro-4-methoxyaniline, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C7H8FNO
Step C: 2,5-Difluoro-lambda/-{3-[(2-{[3-fluoro-4-(methyloxy)phenyl]amino}-4- pyrimidinyl)acetyl]phenyl}benzamide; To a solution containing 2.4 g (6.2 mmol) of lambda/-{3-[(2-chloro-4- pyrimidinyl)acetyl]phenyl}-2,5-difluorobenzamide and 60 mL of i-PrOH was added 0.92 g (6.5 mmol) of 3-fluoro-4-(methyloxy)phenyl amine and 0.1 mL of cone HCI. The reaction mixture was heated at 80 0C for 20 min, then diluted with an additional 60 mL of i-PrOH and heated at 90 0C for 13 h. The reaction mixture was allowed to cool to rt, then filtered. The filter cake was collected, slurried in DCM, and neutralized by the addition of aqueous NaHCO3. The organic layer was separated and the aqueous layer was further extracted with DCM. The combined organic layers were dried over MgSO4, filtered, and concentrated under recduced pressure. The residue was subjected to silica gel chromatography to give 1.76 g (59percent) of the title compound of Step C as a yellow solid: 1H-NMR (d6-DMSO, 400 MHz) delta 10.64 (s, 1 H), 9.83 (s, 1 H), 8.31 (d, 1 H1 J = 5.3 Hz), 8.25 (s, 1 H), 7.77 (d, 1 H1 J = 8.4 Hz), 7.65-7.69 (m, 1 H), 7.61 (d, 1 H1 J = 7.7 Hz), 7.53-7.59 (m, 1 H)1 7.42-7.47 (m, 4 H), 7.27 (d, 1 H, J = 9.2 Hz)1 7.13 (dd, 1 H1 J = 9.5 Hz and 9.5 Hz), 6.64 (d, 1 H, J = 5.3 Hz), 6.20 (s, 1), and 3.80 (s, 3 H), ; ESIMS: 561.07 (M+H+).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 366-99-4.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2009/76140; (2009); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem