These common heterocyclic compound, 645-36-3, name is 2,2-Diethoxyethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 2,2-Diethoxyethanamine
(1-1) Synthesis of Compound 1 1-naphthaldehyde (Wako Pure Chemical Industries, Ltd.)(1.56 g, 10 mmol) and 2,2-diethoxyethanamine (TOKYO CHEMICAL INDUSTRY CO., LTD.)(1.33 g, 10 mmol) were mixed and stirred at 100C for 20 min. After the mixture was cooled to room temperature, EtOH (20 mL) was used for dilution. NaBH4 (0.38 g, 10 mmol) was added dropwise and the mixture was stirred at room temperature for 16 h. After completion of the reaction, EtOH was distilled away under reduced pressure. Then, a product was extracted with AcOEt. The resulting product was purified by silica gel column chromatography (hexane/AcOEt = 5/1) to yield compound 1 (2.29 g, 8.5 mmol, 85%).
The synthetic route of 2,2-Diethoxyethanamine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; National University Corporation Tottori University; Tokyo Women’s Medical University; SHIOTA, Goshi; HOSHIKAWA, Yoshiko; MATSUMOTO, Noriko; MATSUMI, Yoshiaki; MORIMOTO, Minoru; TONOI, Takayuki; SAIMOTO, Hiroyuki; OHASHI, Kazuo; OKANO, Teruo; EP2698365; (2014); A1;,
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