In 2020 J MED CHEM published article about IMMUNE CHECKPOINT BLOCKADE; CANCER; IMMUNOTHERAPY; PD-L1; ACTIVATION; INHIBITORS in [Cheng, Binbin; Ren, Yichang; Niu, Xiaoge; Wang, Wei; Wang, Shuanghu; Tu, Yingfeng; Liu, Shuwen; Chen, Jianjun] Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Peoples R China; [Wang, Jin] AbbVie Inc, N Chicago, IL 60064 USA; [Yang, Deying; Liao, Guochao] Guangzhou Univ Chinese Med, Joint Lab Translat Canc Res Chinese Med, Minist Educ Peoples Republ China, Int Inst Translat Chinese Med, Guangzhou 510006, Peoples R China in 2020, Cited 48. The Name is Benzyl ether. Through research, I have a further understanding and discovery of 103-50-4. COA of Formula: C14H14O
Novel small molecule compounds based on various scaffolds including chalcone, flavonoid, and resorcinol dibenzyl ether were designed and tested for their inhibitory activity against the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 (PD-1/PD-L1) pathway. Among them, compound NP19 inhibited the human PD-1/PD-L1 interaction with IC50 values of 12.5 nM in homogeneous time-resolved fluorescence (HTRF) binding assays. In addition, NP19 dose-dependently elevated IFN-gamma production in a coculture model of Hep3B/OS-8/hPD-L1 and CD3 T cells. Furthermore, NP19 displayed significant in vivo antitumor efficacy in two different mouse models of cancer (a melanoma B16-F10 tumor model and an H22 hepatoma tumor model). Moreover, H&E staining and flow cytometry data suggested that NP19 activated the immune microenvironment in the tumor, which may contribute to its antitumor effects. This work shows NP19 is a promising lead compound for further development as a new generation of small molecule inhibitors targeting the PD-1/PD-L1 pathway.
COA of Formula: C14H14O. About Benzyl ether, If you have any questions, you can contact Cheng, BB; Ren, YC; Niu, XG; Wang, W; Wang, SH; Tu, YF; Liu, SW; Wang, J; Yang, DY; Liao, GC; Chen, JJ or concate me.
Reference:
Ether – Wikipedia,
,Ether | (C2H5)2O – PubChem