Recently I am researching about VASCULAR DISRUPTING AGENTS; INHIBITORS; COMPLEX; DESIGN, Saw an article supported by the Spanish Ministerio de Economia y Competitividad [SAF2015-64629-C2-1-R, BFU2016-75319-R]; CSIC (Proyecto Intramural) [PIE-201668E079]. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Bueno, O; Gargantilla, M; Estevez-Gallego, J; Martins, S; Diaz, JF; Camarasa, MJ; Liekens, S; Perez-Perez, MJ; Priego, EM. The CAS is 101-84-8. Through research, I have a further understanding and discovery of Diphenyl oxide. Computed Properties of C12H10O
Microtubule targeting agents represent a very active arena in the development of anticancer agents. In particular, compounds binding at the colchicine site in tubulin are being deeply studied, and the structural information recently available on this binding site allows structure-directed design of new ligands. Structural comparison of our recently reported high resolution X-Ray structure of the cyclohexanedione derivative TUB075 bound to tubulin and the tubulin-DAMA-colchicine complex has revealed a conformational change in the alpha T5 loop. By a grid-based computational analysis of the tubulin-DAMA-colchicine binding site, we have identified a new favourable binding area in the colchicine-site that was unexplored by our lead TUB075. Thus, based on a structure-guided design, new cyclohexanedione derivatives have been synthesized and tested for tubulin binding and in cellular assays. As a result, we have identified diphenyl ether derivatives with IC50 values around 10-40 nM against three different tumor cell lines and affinity constants for tubulin similar to that of colchicine around 10(7) M-1. As expected, they halted the cell cycle progression at G2/M phase at concentrations as low as 0.08 mu M. (C) 2019 Elsevier Masson SAS. All rights reserved.
Computed Properties of C12H10O. Bye, fridends, I hope you can learn more about C12H10O, If you have any questions, you can browse other blog as well. See you lster.
Reference:
Ether – Wikipedia,
,Ether | (C2H5)2O – PubChem