Authors Gurjar, VK; Pal, D in ROYAL SOC CHEMISTRY published article about HYDROXYACETAMIDE DERIVATIVES; PHARMACOLOGICAL EVALUATION; MOLECULAR-PROPERTIES; DRUG DISCOVERY; CNS ACTIVITIES; PREDICTION; INHIBITORS; LIGANDS; EXTRACT; DOCKING in [Gurjar, Vinod Kumar; Pal, Dilipkumar] Guru Ghasidas Vishwavidyalaya Cent Univ, Dept Pharmaceut Sci, Bilaspur 495009, CG, India in 2020.0, Cited 59.0. SDS of cas: 101-84-8. The Name is Diphenyl oxide. Through research, I have a further understanding and discovery of 101-84-8
New 1,8-naphthyridine-3-carboxylic acid derivatives were designed, synthesized and evaluated for their in vivo antihistaminic activity on guinea pig trachea by using chlorpheniramine as the standard drug. It was found that compound 5a1 displayed a promising bronchorelaxant effect in conscious guinea pigs using the in vivo model. A molecular docking study was performed to understand the molecular interaction and binding mode of the compounds in the active site of the H1 receptor. Furthermore, in silico computational studies were also performed to predict the binding modes and pharmacokinetic parameters of these derivatives. Prior to the start of experimental lab work, PASS software was used to predict the biological activities of these compounds. An in silico PASS, Swiss ADME assisted docking approach was found to be suitable to derive and synthesize effective antihistaminic agents for the present study.
SDS of cas: 101-84-8. Welcome to talk about 101-84-8, If you have any questions, you can contact Gurjar, VK; Pal, D or send Email.
Reference:
Ether – Wikipedia,
,Ether | (C2H5)2O – PubChem