An article Tacroximes: novel unique compounds for the recovery of organophosphorus-inhibited acetylcholinesterase WOS:000498838500002 published article about NERVE AGENTS; REACTIVATION; PESTICIDES; TACRINE; ASSAY; OPTIMIZATION; DERIVATIVES; TOXICITY; EFFICACY; THERAPY in [Gorecki, Lukas; Junova, Lucie; Kucera, Tomas; Hepnarova, Vendula; Kobrlova, Tereza; Muckova, Lubica; Soukup, Ondrej; Korabecny, Jan] Univ Def, Fac Mil Hlth Sci, Dept Toxicol & Mil Pharm, Trebesska 1575, Hradec Kralove 50001, Czech Republic; [Gorecki, Lukas; Junova, Lucie; Hepnarova, Vendula; Prchal, Lukas; Kobrlova, Tereza; Muckova, Lubica; Soukup, Ondrej; Korabecny, Jan] Univ Hosp Hradec Kralove, Biomed Res Ctr, Sokolska 581, Hradec Kralove 50005, Czech Republic in 2019.0, Cited 42.0. The Name is Diphenyl oxide. Through research, I have a further understanding and discovery of 101-84-8. Application In Synthesis of Diphenyl oxide
Aim: Organophosphorus compounds are irreversible inhibitors of AChE. Without immediate countermeasure, intoxication leads quickly to death. None of the clinically-used causal antidotes can ensure a good prognosis for any poisoned patient. When fallen into the wrong hands, organophosphates represent a serious threat to mankind. Results & methodology: Herein, we describe two novel compounds as unique merged molecules built on a tacrine scaffold against organophosphorus intoxication. These reactivators of AChE have balanced physicochemical properties, and should be able to cross the blood-brain barrier with a slightly lowered cytotoxicity profile compared to reference tacrine. Conclusion: Their efficiency compared with pralidoxime and obidoxime was proved against dichlorvos. [GRAPHICS] .
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