Malleron, Jean Luc; Comte, Marie Therese; Gueremy, Claude; Peyronel, Jean Francis; Truchon, Alain; Blanchard, Jean Charles; Doble, Adam; Piot, Odile; Zundel, Jean Luc published the article 《Naphthosultam derivatives: a new class of potent and selective 5-HT2 antagonists》. Keywords: naphtosultam preparation receptor binding; antagonist 5HT2 naphtosultam; naphthoisothiazole dioxide aminoalkyl.They researched the compound: 4-(Piperazin-1-yl)phenol( cas:56621-48-8 ).HPLC of Formula: 56621-48-8. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:56621-48-8) here.
A series of 2-(aminoalkyl)naphtho[1,8-cd]isothiazole 1,1-dioxides I (R = aminoalkyl) was synthesized from I (R = H) and examined in various receptor binding tests. Most compounds demonstrated high affinity for the 5-HT2 receptor with moderate to high selectivity. A member of this series, compound I [R = 3-[4-(p-fluorophenyl)piperazino]propyl] (RP 62203), displays high 5-HT2 receptor affinity (Ki = 0.26 nM), which is resp. more than 100 and 1000 times higher than its affinity for α1 (Ki = 38 nM) and D2 (Ki >1000 nM) receptors. This compound is a potent orally effective and long lasting 5-HT2 antagonist in the mescaline-induced head-twitches test in mice and rats.
In some applications, this compound(56621-48-8)HPLC of Formula: 56621-48-8 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
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