Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, 122775-35-3, formula is C8H11BO4, Name is 3,4-Dimethoxyphenylboronic acid. Then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. Category: ethers-buliding-blocks.
Ismail, Mohamed A.;El-Shafeai, Heba M.;Arafa, Reem K.;Abdel-Rhman, Mohamed H.;Abdel-Latif, Ehab;El-Sayed, Wael M. research published 《 Synthesis, Antiproliferative Activity, Apoptotic Profiling, and In-silico ADME of New Thienylbenzamidine Derivatives》, the research content is summarized as follows. Twelve new thienylbenzamidines and their analogs I [R = Ph, 2,4-di-ClC6H4, HC=CHPh, etc.; X = O, S; Y = H, F] and II [R1 = R2 = H; R1R2 = CH2CH2] were synthesized and their anti-proliferative activity was evaluated against 60 cancer cell lines. The tested compounds showed potent anticancer activity against most cancer cell lines with median growth inhibition. Leukemia and renal cancer cell lines were the most responsive. Compound II [R1 = R2 = H] was the most active exhibiting GI50, total growth inhibition (TGI), and median lethal concentration (LC50) at 1.65, 3.71, and 9.3μM, resp. The benzamidine derivatives exerted their anti-proliferative activity without causing any toxicity in normal human lung fibroblast (WI-38) cells. The selectivity index (SI) ranged from 5.6 to 59.0 fold. Compound I [R = 3,4-di-ClC6H4, etc.; X = O; Y = H] was the most selective compound (SI=59), and it was the least cytotoxic to WI-38 cells. Compounds I exerted their antiproliferative activity by inducing the cell cycle arrest (elevated p53 and downregulated cyclin-dependent kinase 1 (cdk1)) and inducing apoptosis (elevated caspase 3). Compounds I [R = HC=CHPh, etc.; X = S; Y = H] and II [R1R2 = CH2CH2] exerted their activity by inhibiting the growth and proliferation of cancer cells through inhibiting both topoisomerase II (topoII) and thioredoxin reductase1 (txnrd1). Finally, in silico predictions of the physicochem., pharmacokinetic and drug-likeness profiles of these new derivatives proved the oral availability and the inability to cross the blood-brain barrier.
122775-35-3, 3,4-Dimethoxyphenylboronic acid is a useful research compound. Its molecular formula is C8H11BO4 and its molecular weight is 181.98 g/mol. The purity is usually 95%.
3,4-Dimethoxyphenylboronic acid contains varying amounts of anhydride.
3,4-Dimethoxyphenylboronic acid is a bacterial mutagen. A useful intermediate for organic synthesis.
3,4-Dimethoxyphenylboronic acid is a boronate ester that has been shown to be an effective coupling partner for the Suzuki reaction. It has also been used in cancer therapy and as a photochemical probe for the study of biological properties. 3,4-Dimethoxyphenylboronic acid has been shown to demethylate DNA and inhibit methionine aminopeptidase activity. It also cross-couples with halides, such as chlorides or iodides, and activates tertiary alcohols. 3,4-Dimethoxyphenylboronic acid is soluble in organic solvents and can be used in supramolecular chemistry., Category: ethers-buliding-blocks
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem