Liu, Jie; Xiang, Haonan; Jiang, Lvqi; Yi, Wenbin published the artcile< Chemoselective desulfurization-fluorination/bromination of carbonofluoridothioates for the O-trifluoromethylation and O-bromodifluoromethylation of alcohols>, Electric Literature of 52244-70-9, the main research area is carbonofluoridothioate preparation desulfurization fluorination bromination; bromodifluoromethyl ether alkyl preparation chemoselective; alkyl trifluoromethyl ether preparation chemoselective; alc trifluoromethylation.
Herein, a method for synthesizing various alkyl trifluoromethyl e.g., C6H5(CH2)5OCF3 and alkyl bromodifluoromethyl ethers e.g., C6H5(CH2)5OCF2Br using carbonofluoridothioates e.g., C6H5(CH2)5OC(S)F as precursors has been described. Carbonofluoridothioates were obtained upon the reaction of an alc. e.g., C6H5(CH2)5OH and S=CF2 generated via the decomposition of an SCF3 anion, and then selectively transformed into their corresponding trifluoromethyl and bromodifluoromethyl ethers upon changing the reaction conditions. This transformation has also been extended to the one-pot, two-step conversion of alcs. into alkyl trifluoromethyl ethers. A series of alkyl bromodifluoromethyl ethers has also been synthesized. These compounds open up a new avenue for the synthesis of a wide range of useful fluorinated products. In addition, this method is suitable for the late-stage introduction of trifluoromethyl ethers in complex small mols.
Science China: Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Electric Literature of 52244-70-9.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem