The author of 《Enantioselective Dicarbofunctionalization of Unactivated Alkenes by Palladium-Catalyzed Tandem Heck/Suzuki Coupling Reaction》 were Zhang, Zhan-Ming; Xu, Bing; Wu, Lizuo; Wu, Yuanqi; Qian, Yanyan; Zhou, Lujia; Liu, Yu; Zhang, Junliang. And the article was published in Angewandte Chemie, International Edition in 2019. Recommanded Product: 3-Methoxyphenylboronic acid The author mentioned the following in the article:
A highly enantioselective dicarbofunctionalization of unactivated alkenes was implemented by a Pd-catalyzed asym. tandem Heck/Suzuki coupling reaction. This reaction represents the first example of a highly enantioselective intramol. cyclization/cross-coupling of olefin-tethered aryl halides with alkyl-, alkenyl- or arylboronic acids, and provides rapid access to a number of chiral compounds, such as dihydrobenzofurans, indolines, chromanes, and indans bearing a quaternary stereocenter, in good yields with excellent enantioselectivities. The practicality of this reaction was validated in the modification of biol. complex mols. such as peptides, piperitol, CB2 receptor agonists, etc. Moreover, the synthesis of two enantiomers can be easily realized by simple change in the order of the steps in the coupling sequence. In the experiment, the researchers used 3-Methoxyphenylboronic acid(cas: 10365-98-7Recommanded Product: 3-Methoxyphenylboronic acid)
3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Recommanded Product: 3-Methoxyphenylboronic acid
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem