Recommanded Product: 4637-24-5In 2022 ,《Regio- and stereoselective synthesis of spiro-heterocycles bearing the pyrazole scaffold via [3+2] cycloaddition reaction》 was published in Journal of Molecular Structure. The article was written by Islam, Mohammad Shahidul; Haukka, Matti; Soliman, Saied M.; Al-Majid, Abdullah Mohammed; Rahman, A. F. M. Motiur; Bari, Ahmed; Barakat, Assem. The article contains the following contents:
The utility of one-pot multicomponent based [3+2] cycloaddition reaction transformation to prepare a new two hybrids of spirooxindoles engrafted with pyrazole skeleton I (R1 = H and Cl; R2 = F and Cl) was reported. Upon treatment of the electron-deficient olefins based pyrazole motif with in situ the generated azomethine ylides (AY) of sarcosine with the 6-chloro-isatin afforded spiroadducts. To enlighten the regio- and diastereo-selectivity of these spiroheterocycles, single crystal X-ray diffraction anal. was presented. Using Hirshfeld calculations, many short distance contacts such as O…H, Cl…H, N…H, H…C, C…C and Cl…S have a great impact on the mol. packing and the crystal stability of I (R1 = H; R2 = F) and I (R1 = Cl; R2 = Cl). The latter showed some Cl…Cl inter halogen interactions (Cl1…Cl3; 3.358 Å ). Both compounds are polar where I (R1 = Cl; R2 = Cl) (3.995 Debye) has higher dipole moment than I (R1 = H; R2 = F) (3.414 Debye). The NMR chem. shifts were calculated and found in excellent correlations between the calculated and exptl. data were obtained (R2 = 0.94-0.98). In the experiment, the researchers used many compounds, for example, N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Recommanded Product: 4637-24-5)
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