Zheng, Bin; Wang, Shu-Qin; Zhang, Xiao-Ting; Huang, Wan-Yun published their research in Chinese Journal of Structural Chemistry in 2021. The article was titled 《Syntheses and crystal structures of a pair of Z-E enaminonitrile isomerisms》.Electric Literature of C5H13NO2 The article contains the following contents:
A pair of Z-E enaminonitrile isomerisms 2-(3,4-dimethoxyphenyl)-3-((3-methoxyphenyl)amino)acrylonitrile were synthesized and separated by flash column chromatog., and their structures were determined by IR, 1H NMR, 13C NMR, MS and single-crystal X-ray diffraction. The crystal of compound Z-isomer belongs to the monoclinic system, space group C2/c with a = 33.805(7), b = 5.4496(12), c = 18.401(4)Å, β = 112.45(2)°, V = 3133.1(12)Å3, Z = 8, μ = 0.091 mm-1, Dc = 1.143 g·cm-3, the final R = 0.0491 and wR = 0.1439 for 2764 observed reflections. The crystal of compound E-isomer belongs to the triclinic system, space group P1, with a = 8.8403(7), b = 9.0390(6), c = 12.0044(74)Å α = 72.075(5), β = 86.291(5), γ = 81.216(5)°, V = 901.82(10)Å3, Z = 2, T = 293(2) K, μ = 0.079 mm-1, Dc = 1.143 g·cm-3, the final R = 0.0474 and wR = 0.1377 for 3176 observed reflections. The crystal packing of Z and E isomers was governed by intermol. N(2)-H(2)···N(1) and N(2)-H(2)···O(2) interactions resp. to stabilize the structure. In the experiment, the researchers used many compounds, for example, N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Electric Literature of C5H13NO2)
N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Electric Literature of C5H13NO2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem