Roesner, Stefan; Buchwald, Stephen L. published an article in 2016, the title of the article was Continuous-Flow Synthesis of Biaryls by Negishi Cross-Coupling of Fluoro- and Trifluoromethyl-Substituted (Hetero)arenes.Reference of 1-Fluoro-2-methoxybenzene And the article contains the following content:
A continuous-flow method for the regioselective arylation of fluoroarenes and fluoropyridines has been developed. The telescoped procedure reported here consists of a three-step metalation, zincation, and Negishi cross-coupling sequence, providing efficient access to a variety of functionalized 2-fluorobiaryl products. Precise temperature control of the metalation step, made possible by continuous-flow technol., allowed for the efficient preparation of the arylated products in high yields and short residence times. Addnl., several examples of the regioselective arylation of benzotrifluoride derivatives are also provided. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Reference of 1-Fluoro-2-methoxybenzene
The Article related to fluorinated biaryl continuous flow synthesis sonication regioselective arylation, metalation zincation negishi coupling sequence fluoroarene bromoarene sonication, fluoropyridine metalation zincation negishi coupling sequence bromoarene sonication, biaryls, cross-coupling, flow chemistry, palladium, synthetic methods and other aspects.Reference of 1-Fluoro-2-methoxybenzene
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