On July 19, 2021, Xin, Hai-Long; Rao, Xiaofeng; Ishitani, Haruro; Kobayashi, Shu published an article.HPLC of Formula: 321-28-8 The title of the article was Sequential Continuous-Flow Synthesis of 3-Aryl Benzofuranones. And the article contained the following:
A sequential continuous-flow system to produce 3-aryl benzofuranones was developed. Starting from 2,4-di-tert-butylphenol and glyoxylic acid monohydrate, both the initial cyclocondensation and the subsequent Friedel-Crafts alkylation were catalyzed by the same heterogeneous catalyst, Amberlyst-15H. The catalyst has a promising life-time for these two steps, and it was able to be recovered and reused for several runs without deactivation. By using the established flow system, 5,7-di-tert-butyl-3-(3,4-dimethylphenyl)-3H-benzofuran-2-one (Irganox HP-136), which is a com. antioxidant, was prepared in 88% two-step yield. Reactions with various aromatic compounds proceeded well under flow conditions to afford 3-aryl benzo-furanone derivatives in high yields with good functional group compatibility. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).HPLC of Formula: 321-28-8
The Article related to tert butylphenol glyoxylic acid cyclocondensation friedel crafts amberlyst, hydroxy benzofuranone arene sequential continuous flow, aryl benzofuranone preparation, 3-aryl benzofuranones, amberlyst-15h, continuous-flow, heterogeneous catalyst, irganox hp-136 and other aspects.HPLC of Formula: 321-28-8
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