On November 5, 2014, Milner, Phillip J.; Kinzel, Tom; Zhang, Yong; Buchwald, Stephen L. published an article.Safety of 1-Fluoro-2-methoxybenzene The title of the article was Studying Regioisomer Formation in the Pd-Catalyzed Fluorination of Aryl Triflates by Deuterium Labeling. And the article contained the following:
Isotopic labeling was used to determine that a portion of the desired product in the Pd-catalyzed fluorination of electron-rich, nonortho-substituted aryl triflates results from direct C-F cross-coupling. In some cases, formation of a Pd-aryne intermediate is responsible for producing undesired regioisomers. The generation of the Pd-aryne intermediate occurs primarily via ortho-deprotonation of a L路Pd(Ar)OTf (L = biaryl monophosphine) species by CsF and thus competes directly with the transmetalation step of the catalytic cycle. D labeling studies were conducted with a variety of aryl triflates. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Safety of 1-Fluoro-2-methoxybenzene
The Article related to palladium complex catalyzed fluorination coupling aryl triflate deuterium labeling, aryne palladacycle intermediate preparation catalyst fluorination coupling aryl triflate and other aspects.Safety of 1-Fluoro-2-methoxybenzene
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem