On November 25, 2020, Shi, Weimin; Zhang, Jingjie; Zhao, Fengqian; Wei, Wei; Liang, Fang; Zhang, Yin; Zhou, Shaolin published an article.Related Products of 321-28-8 The title of the article was Nucleophilic Aromatic Substitution of Unactivated Aryl Fluorides with Primary Aliphatic Amines by Organic Photoredox Catalysis. And the article contained the following:
A mild and transition-metal-free approach for the nucleophilic aromatic substitution (SNAr) of unactivated fluoroarenes with primary aliphatic amines to form aromatic amines was reported. This reaction is facilitated by the formation of cationic fluoroarene radical intermediates in the presence of an acridinium-based organic photocatalyst under blue-light irradiation Various electron-rich and electron-neutral fluoroarenes are competent electrophiles for this transformation. A wide range of primary aliphatic amines, including amino acid esters, dipeptides and linear and branched amines are suitable nucleophiles. The synthetic utility of this protocol is demonstrated by the late-stage functionalization of several complex drug mols. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Related Products of 321-28-8
The Article related to aryl fluoride aliphatic amine photoredox catalyst nucleophilic aromatic substitution, amines, aryl fluorides, nucleophilic aromatic substitution, visible-light photocatalysis and other aspects.Related Products of 321-28-8
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