On December 9, 2021, Zhang, Shaofei; Vayer, Marie; Noel, Florent; Vukovic, Vuk D.; Golushko, Andrei; Rezajooei, Nazanin; Rowley, Christopher N.; Leboeuf, David; Moran, Joseph published an article.Safety of 1,4-Dimethoxybenzene The title of the article was Unlocking the Friedel-Crafts arylation of primary aliphatic alcohols and epoxides driven by hexafluoroisopropanol. And the article contained the following:
The limitations thar easily overcome using Bronsted acid catalysis in hexafluoroisopropanol (HFIP) as a solvent were reported. Electron-poor aromatic epoxides and aliphatic epoxides undergo stereospecific arylation to give alcs. RC(R1)(Ar)CH2OH/RCH(OH)CH(Ar)OH, and based on the reaction conditions, it can partake in a second nucleophilic substitution with a different arene ArH in one pot. Ph ethanols R3(CH2)2OH (R3 = Ph, 2,6-dichlorophenyl, 2,4,6-trimethylphenyl, etc.) react through a phenonium intermediate, whereas simple aliphatic alcs. e.g., cyclopentanol participate in a rare intermol. SN2 Friedel-Crafts process, delivering linear products e.g., 1,3,5-trimethyl-2-phenethylbenzene exclusively. In this work, an alternative to metal-catalyzed cross-couplings was provided for accessing important scaffolds, and widening the range of applications of the Friedel-Crafts reaction. The experimental process involved the reaction of 1,4-Dimethoxybenzene(cas: 150-78-7).Safety of 1,4-Dimethoxybenzene
The Article related to alc preparation regioselective, epoxide arene ring opening friedel crafts arylation bronstedacid catalyst, arylethane preparation, aliphatic alc arene friedel crafts arylation bronsted acid catalyst and other aspects.Safety of 1,4-Dimethoxybenzene
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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem