Dal Poggetto, Guilherme; Favaro, Denize C.; Nilsson, Mathias; Morris, Gareth A.; Tormena, Claudio F. published an article in 2014, the title of the article was 19F DOSY NMR analysis for spin systems with nJFF couplings.Electric Literature of 321-28-8 And the article contains the following content:
NMR is a powerful method for identification and quantification of drug components and contaminations. These problems present themselves as mixtures, and here, one of the most powerful tools is DOSY. DOSY works best when there is no spectral overlap between components, so drugs containing fluorine substituents are well-suited for DOSY anal. as 19F spectra are typically very sparse. Here, the authors demonstrate the use of a modified 19F DOSY experiment (from the Oneshot sequences) for various fluorinated benzenes. For compounds with significant nJFF coupling constants, as is common, the undesirable J-modulation can be efficiently suppressed using the Oneshot45 pulse sequence. This study highlights 19F DOSY as a valuable and robust method for anal. of mol. systems containing fluorine atoms even where there are large fluorine-fluorine couplings. Copyright © 2014 John Wiley and Sons, Ltd. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Electric Literature of 321-28-8
The Article related to fluorine dosy nmr spin system njff coupling, 19f, dosy, Physical Organic Chemistry: Resonance Spectra (Electron Spin, Nuclear Magnetic and Fourier Transform Nuclear Magnetic, Quadrupole, etc.) and other aspects.Electric Literature of 321-28-8
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