Hfaiedh, Anoir; Ben Ammar, Hamed; Soule, Jean-Francois; Doucet, Henri published an article in 2017, the title of the article was Palladium-catalyzed regioselective C-H bond arylations at the C3 position of ortho-substituted fluorobenzenes.Computed Properties of 321-28-8 And the article contains the following content:
The influence of an ortho-substituent on fluorobenzene derivatives for palladium-catalyzed C-H bond arylation has been explored. In the presence of 2-bromo, 2-chloro and 2-methoxy substituents, the reaction proceeds nicely using a diphosphine-palladium catalyst and potassium acetate/dimethylacetamide (PivOK/DMA) as the catalytic system. In all cases, a regioselective arylation at the other ortho-position to the fluorine atom (C3) was observed A variety of electron-withdrawing substituents on the aryl bromide coupling partner, such as formyl, nitro, nitrile, and also heteroaryl bromides, was tolerated. Moreover, tri(hetero)aryl derivatives containing a fluorobenzene as the central unit have been prepared from 2-bromofluorobenzene through palladium-catalyzed-successive C-H bond (hetero)arylations. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Computed Properties of 321-28-8
The Article related to fluorobenzene aryl bromide regioselective ch bond activation arylation palladium, fluorobiaryl preparation, palladium regioselective ch bond activation arylation catalyst and other aspects.Computed Properties of 321-28-8
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